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    Process for the synthesis of zolpidem
    72.
    发明申请
    Process for the synthesis of zolpidem 审中-公开
    唑吡旦的合成方法

    公开(公告)号：US20050054669A1

    公开(公告)日：2005-03-10

    申请号：US10909468

    申请日：2004-08-02

    Applicant: Yatendra Kumar ,  Mohan Prasad ,  Asok Nath

    Inventor： Yatendra Kumar ,  Mohan Prasad ,  Asok Nath

    IPC: A61K31/4745 ,  C07D471/04

    CPC classification number: C07D471/04

    Abstract: The present invention relates to processes for the preparation of zolpidem of Formula V as shown in the accompanying drawings or pharmaceutically acceptable salts thereof from N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula II. The process includes (a) reacting N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula II with bromine to get the bromo amide of Formula III; (b) condensing the bromo amide of Formula III with 2-amino-5-methylpyridine of Formula IV to get the zolpidem base of Formula V; and (c) converting zolpidem base of Formula V to its hemitartarate salt of Formula VII.

    Abstract translation: 本发明涉及由式II的N，N-二甲基-3-（4-甲基）苯甲酰基丙酰胺制备式V的唑吡旦的方法或其药学上可接受的盐。 该方法包括（a）使式II的N，N-二甲基-3-（4-甲基）苯甲酰基丙酰胺与溴反应得到式III的溴酰胺; （b）将式III的溴酰胺与式IV的2-氨基-5-甲基吡啶缩合得到式V的唑吡旦基; 和（c）将式V的唑吡旦基转化为其式VII的半乳聚糖盐。

    Statistical trend generator for predictive instrument maintenance
    73.
    发明授权
    Statistical trend generator for predictive instrument maintenance 有权
    用于预测仪器维护的统计趋势发生器

    公开(公告)号：US06453279B1

    公开(公告)日：2002-09-17

    申请号：US09434980

    申请日：1999-11-05

    Applicant: Mohan Prasad ,  David N. DeMoura

    Inventor： Mohan Prasad ,  David N. DeMoura

    IPC: G05B902

    CPC classification number: G05B23/0232 ,  G05B23/0283

    Abstract: A method for adaptively scheduling maintenance of a sensor (14) infers the need for maintenance of that sensor on the basis of an error signal indicative of a difference between a measurement signal generated by that sensor and an independently obtained reference signal that is correlated with the measurement signal (16). Although the reference signal is not identical to the measurement signal, the correlation between these two signals assures that when the sensor is functioning, the two signal will track each other over time. The method includes the step of generating this error signal and then monitoring that error signal to detect a triggering event indicative of a mismatch between the reference signal and the measurement signal. This mismatch is indicative of a probability that there exists a malfunction in the sensor. The value of this probability depends on the choice of the triggering event.

    Abstract translation: 一种用于自适应地调度传感器（14）的维护的方法基于指示由该传感器产生的测量信号与独立获得的参考信号之间的差异的误差信号来推测对该传感器的维护的需要， 测量信号（16）。 虽然参考信号与测量信号不同，但是这两个信号之间的相关性确保了当传感器工作时，两个信号将随时间相互追踪。 该方法包括产生该误差信号，然后监视该误差信号以检测表示参考信号与测量信号之间的失配的触发事件的步骤。 这种不匹配表示传感器中存在故障的概率。 该概率的值取决于触发事件的选择。

    Barium salt of benzimidazole derivative
    80.
    发明授权
    Barium salt of benzimidazole derivative 失效
    苯并咪唑衍生物的钡盐

    公开(公告)号：US08415478B2

    公开(公告)日：2013-04-09

    申请号：US12703016

    申请日：2010-02-09

    Applicant: Yatendra Kumar ,  Mahavir Singh Khanna ,  Mohan Prasad

    Inventor： Yatendra Kumar ,  Mahavir Singh Khanna ,  Mohan Prasad

    IPC: C07D401/12

    CPC classification number: C07D401/12 ,  A61K31/4439

    Abstract: The invention relates to crystalline barium salt of (S)-omeprazole, which is (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole. The invention also relates to processes for preparing crystalline barium salt of (S)-omeprazole and pharmaceutical compositions that include the crystalline barium salt of (S)-omeprazole so prepared.

    Abstract translation: 本发明涉及（S） - 奥美拉唑的结晶钡盐，其为（S）-5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基） - 甲基]亚磺酰基〕-1H 苯并咪唑。 本发明还涉及制备（S） - 奥美拉唑的结晶钡盐的方法和包括如此制备的（S） - 奥美拉唑的结晶钡盐的药物组合物。

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