公开(公告)号：US12111197B2

公开(公告)日：2024-10-08

申请号：US17350644

申请日：2021-06-17

申请人： GM Global Technology Operations LLC

发明人： Dmitriy Bruder ,  James R. Salvador ,  Raffaello Ardanese ,  Ryan C. Sekol ,  Thomas A. Yersak ,  Sean Robert Wagner ,  Ronald M Lesperance

IPC分类号： G01F22/00 ,  G01B3/38 ,  G01B5/06 ,  G01B7/16 ,  G01B11/02 ,  G01F23/00 ,  G01N30/02 ,  G01N33/00 ,  G06K7/10 ,  G06T7/62 ,  H01M4/02 ,  H01M4/04 ,  H01M4/139 ,  H01M4/62 ,  H01M10/058 ,  H01M10/42 ,  H01M50/609 ,  H01M10/0525

CPC分类号： G01F22/00 ,  G01B3/38 ,  G01B5/06 ,  G01B7/18 ,  G01B11/02 ,  G01F23/00 ,  G01N30/02 ,  G01N33/0027 ,  G06K7/10366 ,  G06T7/62 ,  H01M4/045 ,  H01M4/139 ,  H01M4/628 ,  H01M10/058 ,  H01M10/4285 ,  H01M50/609 ,  G01N2030/025 ,  H01M2004/027 ,  H01M10/0525

摘要： A quality control system analyzes the quality of a battery cell, with the battery cell defining a gas pouch configured to expand from a deflated configuration to an inflated configuration when filled with a gas formed during a cell formation process. The system comprises a computational system comprising a processor and a memory and a measurement instrument in electronic communication with the computational system. The measurement instrument is arranged to measure a distance defined by the gas pouch and transmit a signal to the computational system corresponding to the distance. The computational system is arranged to analyze the distance with the processor and determine a volumetric measurement of the gas within the gas pouch and compare the volumetric measurement to a threshold in the memory to assess a quality score for the battery cell. A corresponding method analyzes the quality of the battery cell with the quality control system.

公开(公告)号：US11981913B2

公开(公告)日：2024-05-14

申请号：US17746158

申请日：2022-05-17

申请人： Regeneron Pharmaceuticals, Inc.

发明人： Shunhai Wang

IPC分类号： C12N15/86 ,  C07K1/20 ,  C12N7/00 ,  G01N30/02 ,  G01N30/06

CPC分类号： C12N15/86 ,  C12N7/00 ,  G01N30/02 ,  C07K1/20 ,  C12N2710/14143 ,  C12N2750/14142 ,  C12N2750/14143 ,  C12N2750/14152 ,  G01N2030/027 ,  G01N2030/062

摘要： Methods of determining the stoichiometry of a viral capsid and/or determining the heterogeneity of protein components in a viral capsid.

公开(公告)号：US11953433B2

公开(公告)日：2024-04-09

申请号：US16978333

申请日：2019-03-15

申请人： hte GmbH the high throughput experimentation company

发明人： Marius Kirchmann ,  Christoph Hauber

IPC分类号： G01N21/61 ,  G01N21/3504 ,  G01N21/85 ,  G01N30/02 ,  G01N33/28 ,  G06N20/00 ,  G01N21/84 ,  G01N30/88

CPC分类号： G01N21/3504 ,  G01N21/85 ,  G01N30/02 ,  G01N33/2829 ,  G06N20/00 ,  G01N2021/8411 ,  G01N2030/025 ,  G01N2030/8886

摘要： The invention relates to a method for investigating process streams comprising five or more different hydrocarbon-containing components. In the method at least one process flow line (35) is in operative connection with an online IR spectrometer (2) and an online gas chromatograph (1). The process stream passed through the process stream conduit (35) is subjected to an online characterization which comprises measurements both with the online IR spectrometer and with an online gas chromatograph. The spectral data and the chromatography data are mathematically related to one another by suitable statistical models, thus allowing training of a model used for evaluating the analytical data and for characterizing the process streams. The method according to the invention is characterized by short measurement times in the range of seconds and milliseconds and a high accuracy. The method according to the invention for investigating process streams preferably relates to investigation of process streams deriving from processes proceeding in parallel, the process streams preferably deriving from reaction spaces arranged in parallel.

公开(公告)号：US11796431B2

公开(公告)日：2023-10-24

申请号：US17029144

申请日：2020-09-23

申请人： Leonid Krasnobaev

发明人： Leonid Krasnobaev

IPC分类号： G01N1/40 ,  G01N1/22 ,  G01N30/02 ,  G01N30/00 ,  G01N30/12

CPC分类号： G01N1/405 ,  G01N1/2214 ,  G01N30/02 ,  G01N2030/0095 ,  G01N2030/025 ,  G01N2030/128 ,  Y10T436/255

摘要： A thermal desorption tube for use with an electrical power source that includes a tube body having a tube middle portion, a gas inlet, and a gas outlet, a heating element having a first element end and a second element end, wherein the heating element is disposed within the tube body between the gas inlet and the gas outlet, wherein the heating element has a Temperature Coefficient of Resistance (TCR) value greater than 0.003 per degree Celsius, and wherein the first element end and the second element end are configured to electrically couple to a power source, and a sorbent material disposed within the tube middle portion, wherein the sorbent material is disposed in and occupies all available space within the tube middle portion surrounding, within, and adjacent the heating element, and wherein the sorbent material is in direct contact with the heating element.

公开(公告)号：US11786842B2

公开(公告)日：2023-10-17

申请号：US16871657

申请日：2020-05-11

申请人： RESTEK CORPORATION

发明人： Xiaoning Lu ,  Charles Vernon Bartlett ,  Connor Flannery ,  Ahren Iver Green ,  Terrence Scott Reid

IPC分类号： B01D15/20 ,  B01D15/30 ,  B01D15/36 ,  B01D15/38 ,  C07F7/21 ,  G01N30/02 ,  B01J20/26 ,  B01J20/288 ,  G01N30/72

CPC分类号： B01D15/3847 ,  B01D15/20 ,  B01D15/305 ,  B01D15/363 ,  B01J20/261 ,  B01J20/288 ,  C07F7/21 ,  G01N30/02 ,  G01N30/7233 ,  G01N2030/027

摘要： A composition includes a hybrid ligand. The hybrid ligand includes an amine group, an amide group or a sulfonamide group, and hydroxyl groups. A first method includes providing a solution containing a first polar analyte and a second polar analyte, applying the solution to a stationary phase including an immobilized hybrid ligand, applying an elution solvent to the stationary phase such that the first polar analyte and the second polar analyte pass through the stationary phase with different elution times, and collecting the first polar analyte at a first elution time and collecting the second polar analyte at a second elution time after the first elution time. A device of a packed column, a cartridge, a tube, a well plate, a membrane, or a planar thin-layer chromatography plate includes a solid support and a hybrid ligand coupled to the solid support. A second method forms an immobilized hybrid ligand.

公开(公告)号：US20230310329A1

公开(公告)日：2023-10-05

申请号：US18134977

申请日：2023-04-14

申请人： Ironwood Pharmaceuticals. Inc. ,  Forest Laboratories Holdings Limited

发明人： Angelika Fretzen ,  Steven Witowski ,  Alfredo Grossi ,  Hong Zhao ,  Mahendra Dedhiya ,  Yun Mo

IPC分类号： A61K38/10 ,  A61K38/12 ,  A61K47/18 ,  B65D81/26 ,  A61J3/00 ,  A61K47/02 ,  G01N30/02 ,  A61K9/50 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K47/36

CPC分类号： A61K9/50 ,  A61J3/00 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/167 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5078 ,  A61K38/10 ,  A61K38/12 ,  A61K47/02 ,  A61K47/183 ,  A61K47/36 ,  B65D81/26 ,  G01N30/02 ,  G01N2030/027

摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

公开(公告)号：US20230296569A1

公开(公告)日：2023-09-21

申请号：US18152192

申请日：2023-01-10

申请人： ISA Pharmaceuticals B.V.

发明人： Brigitte Elisa Anna Burm ,  Thomas Johannes Maria Beenakker

IPC分类号： G01N30/02

CPC分类号： G01N30/02 ,  G01N2030/027 ,  G01N2030/047

摘要： The disclosed invention is in the field of analytical chemistry. In particular, it relates to methods for improved quantification of analytes in complex mixtures, and to compositions comprising precise amounts of said analytes. The improved method uses stable reference standards.

公开(公告)号：US11760992B2

公开(公告)日：2023-09-19

申请号：US17820242

申请日：2022-08-16

申请人： CureVac Manufacturing GmbH

发明人： Andreas Funkner ,  Stefanie Dorner ,  Stefanie Sewing ,  Johannes Kamm ,  Norbert Broghammer ,  Thomas Ketterer ,  Thorsten Mutzke

IPC分类号： C12N15/10 ,  C12P19/34 ,  B01D61/14 ,  B01D71/12 ,  G01N30/02

CPC分类号： C12N15/1017 ,  B01D61/145 ,  B01D71/12 ,  C12P19/34 ,  G01N30/02 ,  G01N2030/027

摘要： The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into RNA; and conditioning and/or purifying of the solution comprising transcribed RNA by one or more steps of tangential flow filtration (TFF).

公开(公告)号：US11747311B2

公开(公告)日：2023-09-05

申请号：US17208933

申请日：2021-03-22

申请人： Honeywell International Inc.

发明人： Peter M. Michalakos ,  Amanda Childers ,  Stephen Yates ,  Sean Skomurski

IPC分类号： G01N30/02 ,  C01B3/34 ,  C01B3/50 ,  C07C1/12 ,  C01B3/04

CPC分类号： G01N30/02 ,  C01B3/045 ,  C01B3/34 ,  C01B3/50 ,  C07C1/12 ,  G01N2030/025

摘要： The disclosure describes a system for generating hydrogen gas from a hydrocarbon through pyrolysis with reduced soot formation and increased carbon loading. The system includes one or more pyrolysis reactors configured to generate the hydrogen gas from the hydrocarbon through pyrolysis. Each pyrolysis reactor of the one or more pyrolysis reactors includes one or more fibrous substrates and a concentration sensor downstream of at least one fibrous substrate of the one or more fibrous substrates. Each fibrous substrate of the one or more fibrous substrates defines a deposition surface for carbon generated from the pyrolysis of the hydrocarbon and includes a plurality of fibers configured to maintain chemical and structural stability between 850° C. and 1300° C. The concentration sensor is configured to measure a concentration of at least one of a hydrocarbon byproduct or a hydrocarbon soot precursor, such as acetylene.

公开(公告)号：US20230204611A1

公开(公告)日：2023-06-29

申请号：US17680089

申请日：2022-02-24

申请人： DIONEX CORPORATION ,  DIONEX SOFTRON GMBH

发明人： Daniel Hoffmeyer ,  Husam Al-Esawi ,  Tobias Metz ,  Til Richardsen ,  Christoph Hollnagel

IPC分类号： G01N35/00 ,  G01N30/02 ,  G01N35/10

CPC分类号： G01N35/00732 ,  G01N30/02 ,  G01N35/1011 ,  G01N2035/00831 ,  G01N2035/00801 ,  G01N2035/1025 ,  G01N2030/027

摘要： Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.