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公开(公告)号：US06413770B1
公开(公告)日：2002-07-02
申请号：US09136801
申请日：1998-08-19
申请人： Paul Godowski , Austin Gurney , Kenneth J. Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
发明人： Paul Godowski , Austin Gurney , Kenneth J. Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
IPC分类号： C07K14475
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这些核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US20060105427A1
公开(公告)日：2006-05-18
申请号：US11296092
申请日：2005-12-06
申请人： Kevin Baker , David Botstein , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Mary Napier , Margaret Roy , Daniel Tumas , William Wood
发明人： Kevin Baker , David Botstein , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Mary Napier , Margaret Roy , Daniel Tumas , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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73.发明申请公开(公告)号：US20050158830A1
公开(公告)日：2005-07-21
申请号：US11080062
申请日：2005-03-14
申请人： Luc Desnoyers , Napoleone Ferrara , Audrey Goddard , Paul Godowski , Austin Gurney , Kenneth Hillan , William Wood
发明人： Luc Desnoyers , Napoleone Ferrara , Audrey Goddard , Paul Godowski , Austin Gurney , Kenneth Hillan , William Wood
CPC分类号： C07K14/47 , C07K14/50 , Y10S530/866
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those peptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to herologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些肽的核酸分子。 本文还提供了包含这些核酸序列的载体和宿主细胞，包含与英雄多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US06653287B1
公开(公告)日：2003-11-25
申请号：US09660590
申请日：2000-09-13
IPC分类号： A61K3817
CPC分类号： C07K16/244 , A61K38/12 , A61K39/3955 , A61K2300/00
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
摘要翻译： 单独或与内皮素拮抗剂组合的白血病抑制因子拮抗剂可用于治疗心力衰竭。 拮抗剂以治疗有效量以慢性方式施用以达到该目的。
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75.发明授权Method of treating heart failure using leukemia inhibitory factor antagonists optionally with endothelin antagonists 失效使用白细胞抑制因子拮抗剂任选地用内皮素拮抗剂治疗心力衰竭的方法
公开(公告)号：US5837241A
公开(公告)日：1998-11-17
申请号：US693826
申请日：1996-07-26
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , A61K39/395 , C07K16/24 , C07K16/18 , C07K16/22 , C12N5/12
CPC分类号： C07K16/244 , A61K38/12 , A61K39/3955
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
摘要翻译： 单独或与内皮素拮抗剂联合的白血病抑制因子拮抗剂可用于治疗心力衰竭。 拮抗剂以治疗有效量以慢性方式施用以达到该目的。
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公开(公告)号：US6156733A
公开(公告)日：2000-12-05
申请号：US23967
申请日：1998-02-13
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , A61K39/395 , C07K16/24 , C07K14/47 , C07K14/705 , C07K14/715
CPC分类号： C07K16/244 , A61K38/12 , A61K39/3955
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
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77.发明授权Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy 失效使用白血病抑制因子特异性抗体和内皮素拮抗剂治疗心脏肥大
公开(公告)号：US5573762A
公开(公告)日：1996-11-12
申请号：US428002
申请日：1995-04-24
CPC分类号： C07K16/244 , A61K38/12 , A61K39/3955
摘要： A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion, in therapeutically effective amounts, to achieve this purpose.
摘要翻译： 单独或与内皮素拮抗剂组合的白血病抑制因子拮抗剂可用于治疗心力衰竭。 拮抗剂以治疗有效量以慢性方式施用以达到该目的。
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78.发明申请公开(公告)号：US20070026002A1
公开(公告)日：2007-02-01
申请号：US11540884
申请日：2006-09-28
申请人： Hanspeter Gerber , Napoleone Ferrara , Xiao Liang
发明人： Hanspeter Gerber , Napoleone Ferrara , Xiao Liang
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/2839 , C07K2317/73 , C07K2317/76
摘要： Modulators of angiopoietin-like 4 protein are provided along with methods for their use in the treatment of diseases and pathological conditions. Combinations of ANGPTL4 antagonists and other therapeutics, e.g., anti-cancer agents, and methods of their use in the treatment of mammals susceptible to or diagnosed with cancer, or with relapse tumor growth or relapse cancer cell growth are also provided.
摘要翻译： 提供血管生成素样蛋白4蛋白的调节剂及其用于治疗疾病和病理状况的方法。 还提供了ANGPTL4拮抗剂和其它治疗剂（例如抗癌剂）的组合，以及它们用于治疗易患或诊断为癌症的哺乳动物或复发肿瘤生长或复发癌细胞生长的方法。
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79.发明授权公开(公告)号：US07740846B2
公开(公告)日：2010-06-22
申请号：US11185215
申请日：2005-07-19
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/2839 , C07K2317/73 , C07K2317/76
摘要： Modulators of angiopoietin-like 4 protein are provided along with methods for their use in the treatment of diseases and pathological conditions. Combinations of ANGPTL4 antagonists and other therapeutics, e.g., anti-cancer agents, and methods of their use in the treatment of mammals susceptible to or diagnosed with cancer, or with relapse tumor growth or relapse cancer cell growth are also provided.
摘要翻译： 提供血管生成素样蛋白4蛋白的调节剂及其用于治疗疾病和病理状况的方法。 还提供了ANGPTL4拮抗剂和其它治疗剂（例如抗癌剂）的组合，以及它们用于治疗易患或诊断为癌症的哺乳动物或复发肿瘤生长或复发癌细胞生长的方法。
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公开(公告)号：US20060093607A1
公开(公告)日：2006-05-04
申请号：US11185215
申请日：2005-07-19
申请人： Hanspeter Gerber , Napoleone Ferrara , Xiao Liang
发明人： Hanspeter Gerber , Napoleone Ferrara , Xiao Liang
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/2839 , C07K2317/73 , C07K2317/76
摘要： Modulators of angiopoietin-like 4 protein are provided along with methods for their use in the treatment of diseases and pathological conditions. Combinations of ANGPTL4 antagonists and other therapeutics, e.g., anti-cancer agents, and methods of their use in the treatment of mammals susceptible to or diagnosed with cancer, or with relapse tumor growth or relapse cancer cell growth are also provided.
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