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71.发明授权Calcium chelate and gadolinium pharmaceutical composition and methods of X-ray and NMR imaging 失效钙螯合物和钆药物组合物及X射线和NMR成像方法
公开(公告)号：US5098692A
公开(公告)日：1992-03-24
申请号：US601594
申请日：1990-10-22
CPC分类号： A61K47/48076 , A61K47/48707 , A61K49/0002 , Y10S424/90 , Y10T436/24
摘要： Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
摘要翻译： 描述了改进的含金属络合物的药剂，其作为添加剂含有一种或多种络合剂和/或一种或多种弱金属络合物或其混合物。
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72.发明授权X-ray system for the creation of diagnostic X-ray images using contrast media 有权X射线系统用于使用造影剂创建诊断X射线图像公开(公告)号：US07695193B2
公开(公告)日：2010-04-13
申请号：US12084259
申请日：2006-10-25
申请人： Thomas Flohr , Michael Grasruck , Hubertus Pietsch , Karl Stierstorfer , Christoph Suss , Hanns-Joachim Weinmann
发明人： Thomas Flohr , Michael Grasruck , Hubertus Pietsch , Karl Stierstorfer , Christoph Suss , Hanns-Joachim Weinmann
IPC分类号： G01D18/00
CPC分类号： A61K49/04 , A61B5/1075 , A61B6/032 , A61B6/06 , A61B6/4014 , A61B6/4035 , A61B6/4241 , A61B6/4266 , A61B6/4441 , A61B6/481 , A61B6/482 , A61B6/488 , A61B6/504 , A61B6/542 , A61B6/545 , A61B6/583
摘要： An x-ray system is disclosed including a selector for finding an optimum combination between the contrast medium and the energy spectrum of an x-radiation for a scan to optimize the noise-to-contrast ratio. A method for creating X-ray images is also provided. The x-ray images are created with the aid of contrast media by taking into account an optimal combination between the contrast medium and the energy spectrum of an X-radiation used for a scan. A method for the use of a lanthanide-containing complex to produce a contrast medium for optimizing the combination between the contrast medium and the radiation to obtain a maximum contrast-to-noise ratio in an X-ray image is also provided.
摘要翻译： 公开了一种X射线系统，其包括用于找到造影剂与用于扫描的x辐射的能谱之间的最佳组合的选择器，以优化噪声对比度。 还提供了一种用于创建X射线图像的方法。 通过考虑造影介质和用于扫描的X射线的能谱之间的最佳组合，借助造影剂创建X射线图像。 还提供了一种使用含镧系元素的络合物以产生用于优化造影剂和辐射之间的组合以在X射线图像中获得最大对比噪声比的造影剂的方法。
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公开(公告)号：US5876695A
公开(公告)日：1999-03-02
申请号：US388902
申请日：1995-02-14
CPC分类号： A61K47/48076 , A61K47/48707 , A61K49/0002 , Y10S424/90 , Y10T436/24
摘要： Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
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公开(公告)号：US5843399A
公开(公告)日：1998-12-01
申请号：US484317
申请日：1995-06-07
申请人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Raduchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jurgen Conrad
IPC分类号： A61K49/06 , C07C237/04 , C07C237/12 , C07F5/00 , C07F15/02 , A61B5/055 , A61K49/04
CPC分类号： C07C237/04 , A61K49/06 , C07C237/12 , C07F15/025 , C07F5/003 , Y10S514/836
摘要： Chelate compounds of general formula I ##STR1## wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.
摘要翻译： 通式I的螯合物化合物（I）其中X是原子序数21-29,31,32,37-40,42-44,49或57的元素的氢原子和/或金属离子当量 -83和Z1，Z2，R1，R2，R3和R4如本文所定义，以及它们与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的药剂，例如用于NMR成像 。
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75.发明授权Sterile composition comprising a chelate complex for magnetic resonance imaging 失效包含用于磁共振成像的螯合物的无菌组合物
公开(公告)号：US5648063A
公开(公告)日：1997-07-15
申请号：US101811
申请日：1993-08-04
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
CPC分类号： A61K49/1812 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/16 , A61K51/04 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US5560903A
公开(公告)日：1996-10-01
申请号：US462681
申请日：1995-06-05
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07C323/25 , C07D257/02 , C07F9/3817 , C07F9/386 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US5362475A
公开(公告)日：1994-11-08
申请号：US911800
申请日：1992-07-10
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸和一种或多种钆离子的阴离子，以及任选的一种或多种无机和/或有机碱或氨基酸的生理学生物相容性阳离子或阳离子，任选地 具有常用于盖仑制剂中的添加剂，溶于或悬浮于水性介质中。
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78.发明授权Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging 失效用于增强核磁共振成像的钆螯合物的无菌药物组合物
公开(公告)号：US4957939A
公开(公告)日：1990-09-18
申请号：US876497
申请日：1986-06-20
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Pharmaceutical compositions comprising gadolinium chelates are useful for enhancing NMR images.
摘要翻译： 包含钆螯合物的药物组合物可用于增强NMR图像。
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79.发明申请Use of perfluoroalkyl-containing metal complexes as contrast media for diagnosis of Alzheimer's disease 审中-公开使用含全氟烷基的金属络合物作为造影剂用于诊断阿尔茨海默病公开(公告)号：US20070269384A1
公开(公告)日：2007-11-22
申请号：US11797898
申请日：2007-05-08
IPC分类号： A61K49/10
CPC分类号： A61K49/0002 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106
摘要： The invention relates to the use of metal complexes that contain at least one perfluorinated alkyl radical and at least one chelating agent radical and at least one metal ion equivalent of the atomic numbers 21-29, 31-33, 37-39, 42-44, 49 or 57-83, as well as salts thereof for the production of a diagnostic agent for visualizing amyloid-containing plaques.
摘要翻译： 本发明涉及使用含有至少一个全氟化烷基和至少一种螯合剂基团的金属络合物和至少一种等价于原子序数21-29,31-33,37-39,42-44的金属离子 ，49或57-83，以及其盐，用于生产含有淀粉样蛋白斑块的可视化诊断剂。
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80.发明授权DTPA monoamides, pharmaceutical agents containing these compounds, their use and process for their production 失效DTPA单酰胺，含这些化合物的药剂，它们的用途和制备方法公开(公告)号：US06287538B1
公开(公告)日：2001-09-11
申请号：US09066674
申请日：1998-04-28
申请人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
发明人： Heinz Gries , Erich Klieger , Bernd Radüchel , Heribert Schmitt-Willich , Hanns-Joachim Weinmann , Hubert Vogler , Gabriele Schuhmann-Giampieri , Jürgen Conrad
IPC分类号： A61K4904
CPC分类号： C07F5/003 , A61K49/06 , C07C237/04 , C07C237/12 , C07F15/025 , Y10S514/836
摘要： Chelate compounds of general formula I wherein X is a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-40, 42-44, 49 or 57-83, and Z1, Z2, R1, R2, R3 and R4 are as defined herein, as well as their salts with inorganic and/or organic bases, amino acids or amino acid amides, are valuable pharmaceutical agents, e.g., for NMR imaging.
摘要翻译： 通式I的螯合物，其中X是氢原子和/或等价于原子序数21-29,31,32,37-40,42-44,49或57-83，Z1，Z2，R1的元素的金属离子 ，R2，R3和R4如本文所定义，以及它们与无机和/或有机碱，氨基酸或氨基酸酰胺的盐是有价值的药剂，例如用于NMR成像。
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