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1.发明授权Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules 失效使用结合生物分子的螯合顺磁离子增强NMR成像的方法
公开(公告)号：US5021236A
公开(公告)日：1991-06-04
申请号：US20300
申请日：1987-03-02
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid, wherein said chelate complex is bound to a biomolecule.
摘要翻译： 可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物 原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸，其中所述螯合络合物与生物分子结合。
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公开(公告)号：US4647447A
公开(公告)日：1987-03-03
申请号：US573184
申请日：1984-01-23
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01N33/00 , A61K49/00 , C07C101/26 , G01N24/02
CPC分类号： C07F9/386 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1812 , C07C323/25 , C07D257/02 , C07F9/3817
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US5595725A
公开(公告)日：1997-01-21
申请号：US330954
申请日：1994-10-28
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang M utzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang M utzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US4963344A
公开(公告)日：1990-10-16
申请号：US370139
申请日：1989-06-23
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hayden , Heinrich Pfeiffer
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic complex-forming compound containing organic nitrogen, phosphorus, oxygen and/or sulfur, and a complexed ion of the lanthanide elements of atomic number 57-70 or of the transition metals of atomic numbers 21-29, 42 and 44, and, optionally, an inorganic or organic base or acid.
摘要翻译： 可用于影响核磁共振诊断中松弛时间的试剂含有至少一种顺磁性，生理上相容的复盐，其包含来自含有机氮，磷，氧和/或硫的开链或环状络合物形成化合物的螯合物，以及络合物 原子序数57-70的镧系元素或原子序数21-29,42和44的过渡金属的离子，以及任选的无机或有机碱或酸。
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5.发明授权Sterile composition comprising a chelate complex for magnetic resonance imaging 失效包含用于磁共振成像的螯合物的无菌组合物
公开(公告)号：US5648063A
公开(公告)日：1997-07-15
申请号：US101811
申请日：1993-08-04
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
CPC分类号： A61K49/1812 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/16 , A61K51/04 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US5560903A
公开(公告)日：1996-10-01
申请号：US462681
申请日：1995-06-05
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07C323/25 , C07D257/02 , C07F9/3817 , C07F9/386 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸的阴离子和一种或多种原子序数为21至29,42,44或57至83的元素的中心离子或离子，以及任选地， 一种或多种无机和/或有机碱或氨基酸的生理学上生物相容的阳离子或阳离子，任选地与通常用于盖伦制剂中的添加剂一起溶解或悬浮在水性介质中。
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公开(公告)号：US5362475A
公开(公告)日：1994-11-08
申请号：US911800
申请日：1992-07-10
申请人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
发明人： Heinz Gries , Douwe Rosenberg , Hanns-Joachim Weinmann , Ulrich Speck , Wolfgang Mutzel , Georg-Alexander Hoyer , Heinrich Pfeiffer, deceased , Franz-Josef Renneke
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28 , A61B5/055
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.
摘要翻译： 诊断介质包含至少一种生理上良好耐受的复合盐，其包含络合酸和一种或多种钆离子的阴离子，以及任选的一种或多种无机和/或有机碱或氨基酸的生理学生物相容性阳离子或阳离子，任选地 具有常用于盖仑制剂中的添加剂，溶于或悬浮于水性介质中。
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8.发明授权Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging 失效用于增强核磁共振成像的钆螯合物的无菌药物组合物
公开(公告)号：US4957939A
公开(公告)日：1990-09-18
申请号：US876497
申请日：1986-06-20
IPC分类号： A61K49/04 , A61K49/06 , A61K49/10 , A61K49/18 , C07C323/25 , C07D257/02 , C07F9/38 , G01R33/28
CPC分类号： C07C323/25 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/105 , A61K49/106 , A61K49/108 , A61K49/143 , A61K49/16 , A61K49/18 , A61K49/1806 , A61K49/1809 , A61K49/1812 , C07D257/02 , C07F9/3817 , C07F9/386 , G01R33/5601 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： Pharmaceutical compositions comprising gadolinium chelates are useful for enhancing NMR images.
摘要翻译： 包含钆螯合物的药物组合物可用于增强NMR图像。
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