Method for producing palladium complex compound
    71.
    发明授权
    Method for producing palladium complex compound 失效
    钯配合物的制造方法

    公开(公告)号:US06706905B1

    公开(公告)日:2004-03-16

    申请号:US09458080

    申请日:1999-12-10

    IPC分类号: C07F1702

    CPC分类号: C07F15/006 C07F15/0066

    摘要: An aromatic compound represented by the general formula Ar1X is reacted with a palladium compound and a phosphine derivative, in the presence of a first basic substance, thereby producing a palladium-complex compound represented by the general formula Ar1—PdL2X. This palladium-complex compound is reacted with a benzoic acid represented by the general formula Ar2—COOH, in the presence of a second basic substance, thereby producing another palladium-complex compound represented by the following general formula. The above palladium-complex compounds are useful as catalysts and can be produced easily by the above reactions. In the above general formulas, Ar1 is an aryl group; and X is a halogen that is fluorine, chlorine, bromine or iodine, trifluoromethanesulfonate group, an alkylsulfonate group having a carbon atom number of 1-4, or a substituted or unsubstituted arylsulfonate group; each L is independently a phosphine ligand; and Ar2 is an aryl group.

    摘要翻译: 在通式Ar 1 X表示的芳香族化合物与钯化合物和膦衍生物在第一碱性物质的存在下反应,由此制备由通式Ar 1〜 PdL2X。 在第二碱性物质的存在下,使该钯络合物与通式为Ar 2 -COOH表示的苯甲酸反应,由此生成由以下通式表示的另一种钯络合物。 复合化合物可用作催化剂,并且可以通过上述反应容易地制备。 在上述通式中,Ar 1是芳基; X是氟,氯,溴或碘的卤素,三氟甲磺酸酯基,碳原子数为1-4的烷基磺酸酯基或取代或未取代的芳基磺酸酯基; 每个L独立地是膦配体; Ar 2为芳基。

    Process for producing trifluoromethylbenzylamines
    72.
    发明授权
    Process for producing trifluoromethylbenzylamines 失效
    制备三氟甲基苄胺的方法

    公开(公告)号:US06376712B2

    公开(公告)日:2002-04-23

    申请号:US09833211

    申请日:2001-04-12

    IPC分类号: C07C21100

    CPC分类号: C07C209/40 C07C211/29

    摘要: The present invention relates to a process for producing a trifluoromethylbenzylamine represented by the general formula (1), where R1 represents hydrogen atom, a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, or trifluoromethyl group. This process includes the step of reducing an oxime by hydrogen in an organic solvent in the presence of a catalyst and ammonia. The oxime is represented by the general formula (2), where R1 is defined as above, and R2 represents hydrogen atom, an alkyl group or an aralkyl group. With this process, the trifluoromethylbenzylamine can be produced with high yield.

    摘要翻译: 本发明涉及由通式(1)表示的三氟甲基苄胺的制备方法,其中R1表示氢原子,选自氟,氯,溴和碘的卤素原子或三氟甲基。 该方法包括在催化剂和氨的存在下,通过有机溶剂中的氢还原肟的步骤。 肟由通式(2)表示,其中R 1如上定义,R 2表示氢原子,烷基或芳烷基。 通过该方法,可以高产率制备三氟甲基苄胺。