公开(公告)号：US20080306565A1

公开(公告)日：2008-12-11

申请号：US12095212

申请日：2005-12-16

申请人： Nils Holmstrom ,  Kjell Noren

发明人： Nils Holmstrom ,  Kjell Noren

IPC分类号： A61N1/00 ,  A61F2/02

CPC分类号： A61B7/00 ,  A61B7/04 ,  A61N1/3627 ,  A61N1/36514

摘要： In an implantable medical device and a method and computer-readable medium for operating the medical device to detect a condition of a heart of a patient, activity level of a patient and acoustic energy in a patient are sensed, and acoustic signals are generated that are indicative of heart sounds of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles. A signal corresponding to a first sound is extracted from the sensed acoustic signal of a cardiac cycle. A relation is calculated between a first signal corresponding to the first heart sound in a first activity range, and a second signal corresponding to the first heart sound in a second predetermined activity level range. The calculated relation is compared with at least one reference value to detect the condition or a change of the condition.

摘要翻译： 在可植入医疗装置和用于操作医疗装置以检测患者心脏状况的方法和计算机可读介质中，感测患者的活动水平和患者的声能，并且生成声信号 指示在连续心脏周期期间心脏周期的预定时间段的患者的心脏声音。 从感测到的心律周期的声信号中提取对应于第一声音的信号。 在与第一活动范围内的第一心音相对应的第一信号与对应于第二预定活动水平范围中的第一心音的第二信号之间计算关系。 将计算的关系与至少一个参考值进行比较以检测条件或状况的变化。

公开(公告)号：US06792309B1

公开(公告)日：2004-09-14

申请号：US09937339

申请日：2001-09-21

申请人： Kjell Noren

发明人： Kjell Noren

IPC分类号： A61N1365

CPC分类号： A61N1/056 ,  A61N1/36585

摘要： A multi-sensor system for controlling an implantable heart stimulator, and an implantable heart stimulator containing such a multi-sensor system, have a piezoelectric pressure sensor adapted for placement in the blood stream of a subject, the piezoelectric pressure sensor having at least one electrode that is adapted for electrical contact with the blood stream, and an oxygen pressure sensor having a measurement electrode formed by the (at least one) electrode of the piezoelectric pressure sensor.

摘要翻译： 用于控制可植入心脏刺激器的多传感器系统和包含这种多传感器系统的可植入心脏刺激器具有适于放置在受试者血液中的压电压力传感器，所述压电压力传感器具有至少一个电极 适于与血流电接触的氧气压力传感器，以及具有由压电压力传感器的（至少一个）电极形成的测量电极的氧气压力传感器。

公开(公告)号：US6016443A

公开(公告)日：2000-01-18

申请号：US48521

申请日：1998-03-26

申请人： Christer Ekwall ,  Kjell Noren

发明人： Christer Ekwall ,  Kjell Noren

IPC分类号： A61N1/365 ,  A61B5/04

CPC分类号： A61N1/36514 ,  A61N1/36585

摘要： An ischemia detector includes repolarization sensor which senses repolarization of the heart of a patient and delivers corresponding repolarization signals to a detecting unit and a workload sensor which senses the workload of the patient and delivers corresponding workload signals to the detecting unit. The detecting unit identifies a state of ischemia as existing upon the occurrence of a predetermined relation between sensed repolarization and sensed workload.

摘要翻译： 缺血检测器包括复极度传感器，其感测患者心脏的复极化，并将相应的复极信号传送到检测单元和工作负载传感器，其感测患者的工作量并将相应的工作负载信号传送到检测单元。 检测单元在检测到的复极化和检测到的工作负荷之间发生预定关系时，识别存在的局部缺血状态。

公开(公告)号：US5697957A

公开(公告)日：1997-12-16

申请号：US705272

申请日：1996-08-29

申请人： Kjell Noren ,  Hans Strandberg

发明人： Kjell Noren ,  Hans Strandberg

IPC分类号： A61B5/0452 ,  A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3704 ,  A61N1/3712 ,  A61N1/3716 ,  Y10S128/901

摘要： In a method and apparatus for suppressing electrode polarization components in a sensed cardiac signal, the sensed cardiac signal is added to either a differentiated or autocorrelated sensed cardiac signal and a difference is formed between the original sensed cardiac signal and the autocorrelated or differentiated signal, thereby extracting an evoked response component from the sensed cardiac signal, the evoked response component otherwise being overshadowed by the much higher-amplitude polarization component.

摘要翻译： 在用于抑制检测到的心脏信号中的电极极化分量的方法和装置中，感测到的心脏信号被加到差分或自相关感测的心脏信号中，并且在原始感测心脏信号与自相关或微分信号之间形成差异，由此 从所感测到的心脏信号中提取诱发反应分量，否则被高得多的振幅偏振分量遮蔽的诱发响应分量。

公开(公告)号：US5649966A

公开(公告)日：1997-07-22

申请号：US603455

申请日：1996-02-20

申请人： Kjell Noren ,  Jakub Hirschberg

发明人： Kjell Noren ,  Jakub Hirschberg

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/362 ,  A61N1/3625 ,  A61N1/368

摘要： In a method and apparatus for stimulating and/or diagnosing the heart, a voltage is applied to the heart over at least a selected portion of the heart during an activation interval with a rise and fall, with the voltage having a first derivative with an absolute value that is less than the value of the derivative which, for a patient in question, would trigger the patient's heartbeat, and with a duration from beginning to end of each applied voltage signal of at least 30 ms.

摘要翻译： 在用于刺激和/或诊断心脏的方法和装置中，在具有上升和下降的激活间隔期间，至少在心脏的选定部分将心脏施加电压，其中电压具有绝对的一阶导数 值小于对于所讨论的患者将导致患者心跳并且具有至少30ms的每个施加的电压信号的开始到结束的持续时间的导数的值。

公开(公告)号：US5556419A

公开(公告)日：1996-09-17

申请号：US342051

申请日：1994-11-17

申请人： Karin Jarverud ,  Kjell Noren

发明人： Karin Jarverud ,  Kjell Noren

IPC分类号： A61B5/0402 ,  A61B5/0452 ,  A61N1/362 ,  A61N1/365 ,  A61B5/04 ,  A61N1/36

CPC分类号： A61N1/3622

摘要： A device for identifying abnormal conditions in a heart retrograde conduction and tachyarrhythmias in particular, includes a differentiating circuit electrically connected to a heart to be monitored in order to differentiate ECG signals from the heart. The differentiated signal is plotted against the ECG signal. The radius (distance from a point on the resulting curve from the origin of the plot axes) in the resulting curve is calculated in a calculator unit. The radius obtained is then compared with a threshold value in a comparator and a sequence for the progression of the radius in relation to the threshold value is obtained and compared with previously obtained sequences stored in a sequence analyzer.

摘要翻译： 特别是用于识别心脏逆行传导和快速性心律失常的异常状况的装置，包括电连接到要被监测的心脏的微分电路，以便将ECG信号与心脏区分开来。 差分信号相对于ECG信号绘制。 在计算器单元中计算所得曲线中的半径（来自曲线轴的原点上的点的距离）。 然后将获得的半径与比较器中的阈值进行比较，并获得相对于阈值进行半径的序列，并与存储在序列分析器中的先前获得的序列进行比较。

公开(公告)号：US5427112A

公开(公告)日：1995-06-27

申请号：US51250

申请日：1993-04-23

申请人： Kjell Noren ,  Kurt Hoegnelid

发明人： Kjell Noren ,  Kurt Hoegnelid

IPC分类号： A61B5/0452 ,  A61N1/365 ,  A61B5/00

CPC分类号： A61N1/36585 ,  A61N1/36507

摘要： A device for analyzing the function of a heart, containing a measurement unit for generating a first measurement signal related to a first electrical or mechanical heart variable and an evaluation unit for evaluating the measurement signal, further contains a circuitry for generating a parameter signal related to a heart variable, the evaluation unit analyzing the related values for the measurement signal and the parameter signal. The device can be used for detecting a number of functional aberrations, such as bradycardia, tachyarrhythmia, retrograde conduction, ischemia and ectopia, and for controlling pacemakers and defibrillators.

摘要翻译： 一种用于分析心脏功能的装置，包括用于产生与第一电气或机械心脏变量相关的第一测量信号的测量单元和用于评估测量信号的评估单元，还包括用于产生与 心脏变量，评估单元分析测量信号和参数信号的相关值。 该装置可用于检测许多功能异常，例如心动过缓，快速性心律失常，逆行传导，缺血和异位，以及用于控制起搏器和除颤器。

公开(公告)号：US5385576A

公开(公告)日：1995-01-31

申请号：US101727

申请日：1993-08-04

申请人： Kjell Noren ,  Pia Hagel ,  Kurt Hoegnelid

发明人： Kjell Noren ,  Pia Hagel ,  Kurt Hoegnelid

IPC分类号： A61B5/05 ,  A61B5/053 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61N1/3962 ,  A61N1/395

摘要： In a method and apparatus for detecting ventricular fibrillation, a measured impedance signal, dependent on the blood volume in the heart, is evaluated, and ventricular fibrillation is assumed to be present if the level of the measured impedance signal falls below a predetermined threshold. This is based on the perception that as the heart fills with blood, given the presence of ventricular fibrillation, the level of the measured impedance signal will decrease. The apparatus also includes circuitry for treating the detected ventricular fibrillation.

摘要翻译： 在用于检测心室颤动的方法和装置中，评估取决于心脏中的血液体积的测量阻抗信号，并且如果测得的阻抗信号的电平低于预定阈值，则认为存在心室颤动。 这是基于以下认识：当心脏充满血液时，鉴于心室颤动的存在，测得的阻抗信号的水平将降低。 该装置还包括用于治疗所检测的心室颤动的电路。