公开(公告)号：US4293546A

公开(公告)日：1981-10-06

申请号：US171852

申请日：1980-07-24

Applicant: Claude H. Nash, III ,  Marcia C. Shearer ,  Kenneth M. Snader ,  Joseph R. Valenta ,  David Cooper

Inventor： Claude H. Nash, III ,  Marcia C. Shearer ,  Kenneth M. Snader ,  Joseph R. Valenta ,  David Cooper

IPC: C07H15/252 ,  C12P19/56 ,  A61K35/00

CPC classification number: C07H15/252 ,  C12P19/56 ,  C12R1/62

Abstract: A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Abstract translation: 一种新型的蒽环类抗生素复合物，fragilomycin复合物，是通过培养含有Streptosporangium fragilis Shearer sp。 nov。 ATCC 31519微生物在含水营养培养基中浸没有氧条件。 fragilomycin复合物及其主要生物活性成分，fragilomycin A具有抗菌活性。