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23 条记录 (耗时 0.026 秒)

    Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
    9.
    发明授权
    Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto 有权
    吡咯并苯并二氮杂衍生物，包含其的组合物及其相关方法

    公开(公告)号：US07834005B2

    公开(公告)日：2010-11-16

    申请号：US12370856

    申请日：2009-02-13

    申请人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip W. Howard ,  Luke Y. Hsiao ,  Gregory Turner

    发明人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip W. Howard ,  Luke Y. Hsiao ,  Gregory Turner

    IPC分类号： C07D487/04 ,  A61K31/551 ,  A61P31/00

    CPC分类号： C07D487/04

    摘要： Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.

    摘要翻译： 公开了式I的化合物，其中X，Y，R 1 -R 7，T 1，T 2，Z和p如本文所述; 包含式I化合物和载体的药物组合物; 一种抑制细胞生长的方法，该方法包括以有效抑制生长式I化合物的量给药; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的剂量施用式I化合物; 治疗细胞的病毒，寄生或细菌感染的方法，该方法包括以有效治疗式I化合物的病毒，寄生或细菌感染的量施用; 以及制备如本文所述的式I化合物的方法。

    Aminoflavone compounds, compositions, and methods of use thereof
    10.
    发明授权
    Aminoflavone compounds, compositions, and methods of use thereof 失效
    氨基黄酮化合物，组合物及其使用方法

    公开(公告)号：US06812246B2

    公开(公告)日：2004-11-02

    申请号：US10240883

    申请日：2003-06-12

    申请人： Kenneth M. Snader ,  B. Rao Vishnuvajjala ,  Tsutomu Akama

    发明人： Kenneth M. Snader ,  B. Rao Vishnuvajjala ,  Tsutomu Akama

    IPC分类号： A61K3135

    CPC分类号： C07D311/30

    摘要： The invention provides an aminoflavone having formula (I), wherein each of R1 and R2 is H, COCH2—R7, wherein R7 is amino alkylamino, dialkylamino, or alkyl- or dialkylaminoalkyl, or an &agr;-amino acid residue, provided that at least one of R1 or R2 is other than H, and R3 is H, branched or straight-chain alkyl, hydroxyalkyl, alkanoyloxyalkyl, alkanoyloxy, alkoxy, or alkoxyalkyl, or pharmaceutically acceptable salts thereof. The present invention also provides a pharmaceutical composition comprising an aminoflavone as described above, and a method of inhibiting the growth of a tumor in a host by administering a tumor growth-inhibiting amount of an aminoflavone compound having the formula as described above.

    摘要翻译： 本发明提供具有式（I）的氨基黄酮，其中R 1和R 2各自为H，COCH 2 -R 7，其中R 7为氨基烷基氨基，二烷基氨基或烷基 - 或二烷基氨基烷基， 或α-氨基酸残基，条件是R 1或R 2中的至少一个不是H，R 3是H，支链或直链烷基，羟烷基，烷酰氧基烷基，烷酰氧基，烷氧基 ，或烷氧基烷基，或其药学上可接受的盐。 本发明还提供了包含如上所述的氨基黄酮的药物组合物，以及通过施用具有抑制肿瘤生长抑制量的具有上述通式的氨基黄酮化合物来抑制宿主中肿瘤生长的方法。