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公开(公告)号：US20060142753A1
公开(公告)日：2006-06-29
申请号：US11355465
申请日：2006-02-16
申请人： David Francischelli , Eduardo Warman , Rahul Mehra , Mark Stewart , James Skarda , Harry Puryear , David Schwartzman
发明人： David Francischelli , Eduardo Warman , Rahul Mehra , Mark Stewart , James Skarda , Harry Puryear , David Schwartzman
IPC分类号： A61B18/18
CPC分类号： A61B18/1445 , A61B5/04 , A61B18/12 , A61B2018/00065 , A61B2018/00363 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1472 , A61B2218/002 , A61N1/403
摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the local electrogram is measured with electrodes located adjacent tissue to be ablated so that the ablation energy to ablation elements can be selectively reduced or terminated when transmurality is detected.
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72.发明申请Cardiac stimulation device and method for automatic lower pacing rate optimization 审中-公开心脏刺激装置及自动下限起搏率优化方法公开(公告)号：US20050234519A1
公开(公告)日：2005-10-20
申请号：US10824898
申请日：2004-04-15
申请人： Paul Ziegler , Douglas Hettrick , Rahul Mehra
发明人： Paul Ziegler , Douglas Hettrick , Rahul Mehra
CPC分类号： A61N1/365 , A61N1/3622
摘要： A method and device for determining an optimal lower rate and adjusting the programmed lower pacing rate to the optimal rate that includes monitoring a parameter in response to therapy delivered at a first rate during a first time period to generate first parameter data, and determining whether the therapy was delivered for a predetermined portion of the first time period. The parameter is monitored in response to the therapy delivered at a next rate during a next time period to generate next parameter data, and a determination is made as to whether the therapy was delivered for a predetermined portion of the next time period. A metric corresponding to the first parameter data is determined to generate a first parameter metric, and corresponding to the next parameter data to generate a next parameter metric used for determining an optimal therapy delivery rate.
摘要翻译： 一种用于确定最佳较低速率并将编程的较低起搏速率调整到最佳速率的方法和装置，其包括响应于在第一时间段期间以第一速率递送的治疗来监测参数以产生第一参数数据，以及确定是否 治疗在第一时间段的预定部分被递送。 响应于在下一时间段期间以下一个速率递送的治疗来监测参数以产生下一个参数数据，并且确定治疗是否在下一个时间段的预定部分被递送。 确定对应于第一参数数据的度量以产生第一参数度量，并且对应于下一个参数数据，以生成用于确定最佳治疗传递率的下一个参数度量。
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公开(公告)号：US20050165392A1
公开(公告)日：2005-07-28
申请号：US11003451
申请日：2004-12-03
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/00738 , A61B2018/1253 , A61B2018/1472
摘要： A system and method of making a lesion on living tissue including providing an electrosurgical system, determining a desired lesion depth, selecting a power setting, and applying electrical energy to the living tissue. The system includes an instrument having an electrode at a distal portion thereof, and a power source having multiple available power settings. The power source is electrically connected to the electrode. The step of applying electrical energy includes energizing the electrode at the selected power setting for a recommended energization time period that is determined by reference to predetermined length of time information and based upon the desired lesion depth and the selected power setting. The system preferably further includes a fluid source for irrigating the electrode at an irrigation rate. In this regard, the predetermined length of time information is generated as a function of irrigation rate.
摘要翻译： 一种在活体组织上形成损伤的系统和方法，包括提供电外科系统，确定期望的病变深度，选择功率设定以及向生物体组织施加电能。 该系统包括在其远端部分具有电极的仪器和具有多个可用功率设置的电源。 电源电连接到电极。 施加电能的步骤包括以所选择的功率设置激励电极，以建立通电时间段，该推荐通电时间周期通过参考预定时间长度信息确定，并且基于期望的病变深度和所选择的功率设置。 该系统优选地还包括用于以灌溉速率冲洗电极的流体源。 在这方面，根据灌溉速率产生预定长度的时间信息。
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公开(公告)号：US20050143729A1
公开(公告)日：2005-06-30
申请号：US11061425
申请日：2005-02-18
申请人： David Francischelli , Richard Comben , Michael Hoey , Rahul Mehra , Jon Ocel , Robert Pearson , Paul Trescony , Scott Jahns
发明人： David Francischelli , Richard Comben , Michael Hoey , Rahul Mehra , Jon Ocel , Robert Pearson , Paul Trescony , Scott Jahns
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2018/00065 , A61B2018/00351 , A61B2018/00577 , A61B2018/1435 , A61B2018/1472 , A61B2218/002
摘要： A device for ablating tissue is provided. The device comprises a conductive element with a channel for irrigating fluid formed therein, which is in contact with a non-conductive microporous interface. All or a portion of the interface may be removable. When the interface is removed, a portion of the conductive element is exposed for use in ablating tissue. Methods of using the device and of removing the interface are also provided.
摘要翻译： 提供了用于消融组织的装置。 该装置包括导电元件，其具有用于在其中形成的冲洗流体的通道，其与非导电微孔界面接触。 界面的全部或部分可以是可移动的。 当界面被去除时，导电元件的一部分被暴露以用于消融组织。 还提供了使用设备和移除界面的方法。
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公开(公告)号：US06899711B2
公开(公告)日：2005-05-31
申请号：US10414779
申请日：2003-04-16
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.
摘要翻译： 一种用于治疗心律失常（例如心房颤动）的导管组件和方法，通过诸如左心房的腔室电隔离血管（例如肺静脉）。 导管组件包括导管主体和至少一个电极。 导管主体包括近端部分，中间部分和远端部分。 中间部分从近端部分延伸并且限定纵向轴线。 远侧部分从中间部分延伸并且形成横向于纵向轴线的基本上闭合的环。 沿着环设置至少一个电极。 利用这种构造，环路被轴向地指向与容器孔周围的室壁接触。 在通电时，电极消除围绕血管口的连续病变图案，从而将容器与腔室电隔离。
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公开(公告)号：US20050033280A1
公开(公告)日：2005-02-10
申请号：US10923073
申请日：2004-08-20
申请人： David Francischelli , Rahul Mehra
发明人： David Francischelli , Rahul Mehra
IPC分类号： A61B18/14
CPC分类号： A61B18/1445 , A61B18/1402 , A61B2017/2945 , A61B2018/00994 , A61B2018/126 , A61B2018/1432 , A61B2018/1472
摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.
摘要翻译： 一种治疗房性快速性心律失常的方法和系统。 该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。 钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。 通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。
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公开(公告)号：US06827715B2
公开(公告)日：2004-12-07
申请号：US10056806
申请日：2002-01-25
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/00738 , A61B2018/1253 , A61B2018/1472
摘要： A system and method of making a lesion on living tissue including providing an electrosurgical system, determining a desired lesion depth, selecting a power setting, and applying electrical energy to the living tissue. The system includes an instrument having an electrode at a distal portion thereof, and a power source having multiple available power settings. The power source is electrically connected to the electrode. The step of applying electrical energy includes energizing the electrode at the selected power setting for a recommended energization time period that is determined by reference to predetermined length of time information and based upon the desired lesion depth and the selected power setting. The system preferably further includes a fluid source for irrigating the electrode at an irrigation rate. In this regard, the predetermined length of time information is generated as a function of irrigation rate.
摘要翻译： 一种在活体组织上形成损伤的系统和方法，包括提供电外科系统，确定期望的病变深度，选择功率设定以及向生物体组织施加电能。 该系统包括在其远端部分具有电极的仪器和具有多个可用功率设置的电源。 电源电连接到电极。 施加电能的步骤包括以所选择的功率设置激励电极，以建立通电时间段，该推荐通电时间周期参考预定时间长度信息确定，并且基于期望的病变深度和所选择的功率设置。 该系统优选地还包括用于以灌溉速率冲洗电极的流体源。 在这方面，根据灌溉速率产生预定长度的时间信息。
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公开(公告)号：US06773433B2
公开(公告)日：2004-08-10
申请号：US10414757
申请日：2003-04-16
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.
摘要翻译： 一种用于治疗心律失常（例如心房颤动）的导管组件和方法，通过诸如左心房的腔室电隔离血管（例如肺静脉）。 导管组件包括导管主体和至少一个电极。 导管主体包括近端部分，中间部分和远端部分。 中间部分从近端部分延伸并且限定纵向轴线。 远侧部分从中间部分延伸并且形成横向于纵向轴线的基本上闭合的环。 沿着环设置至少一个电极。 利用这种构造，环路被轴向地指向与容器孔周围的室壁接触。 在通电时，电极消除围绕血管口的连续病变图案，从而将容器与腔室电隔离。
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79.再颁专利
公开(公告)号：USRE36765E
公开(公告)日：2000-07-04
申请号：US831052
申请日：1997-04-01
申请人： Rahul Mehra
发明人： Rahul Mehra
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/395
摘要： A method and apparatus for detecting and treating atrial fibrillation. In response to detecting atrial fibrillation, the device derives an escape interval based on one or more preceding intervals between ventricular depolarizations. The escape interval is initiated in response to a ventricular depolarization, and in response to the expiration of the escape interval, an atrial cardioversion pulse is delivered. In one embodiment of the invention, the cardioverting pulse is delivered immediately upon expiration of the derived escape interval. In a second embodiment of the invention, a ventricular pacing pulse is delivered on expiration of the escape interval, with an atrial cardioversion pulse following after a short delay.
摘要翻译： 一种用于检测和治疗心房颤动的方法和装置。 响应于检测心房颤动，装置基于心室去极化之间的一个或多个先前间隔导出逃逸间隔。 逃逸间隔是响应于心室去极化而开始的，并且响应于逃逸间隔的期满，输送心房心律转复脉冲。 在本发明的一个实施例中，在导出的逃生间隔期满后立即传送心律转换脉冲。 在本发明的第二实施例中，在逃避间隔期满时输送心室起搏脉冲，随后在短暂延迟后跟随心房心律转复脉冲。
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公开(公告)号：US5620468A
公开(公告)日：1997-04-15
申请号：US627959
申请日：1996-04-02
申请人： Luc R. Mongeon , Michael R. S. Hill , Rahul Mehra
发明人： Luc R. Mongeon , Michael R. S. Hill , Rahul Mehra
CPC分类号： A61N1/385 , A61N1/3962 , A61N1/395
摘要： A method and apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a series of low energy pulse bursts is delivered, separated by defined inter-burst intervals, and including bursts unsynchronized to heart depolarizations. Detection of termination of fibrillation during inter-burst intervals results in cancellation of further pulse bursts to prevent reinduction of fibrillation.
摘要翻译： 一种用于治疗原纤维性颤动的方法和装置，特别是心房颤动。 响应于原纤维化的检测，一系列低能量脉冲串被传送，通过限定的突发间隔隔开，并且包括与心脏去极化不同步的突发。 在突发间隔期间检测到颤动的终止导致进一步的脉冲脉冲的消除，以防止纤维性颤动的再诱导。
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