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    Methods for increasing thermogenic adipocytes
    72.
    发明授权
    Methods for increasing thermogenic adipocytes 有权
    增加产热脂肪细胞的方法

    公开(公告)号：US08703694B2

    公开(公告)日：2014-04-22

    申请号：US13403657

    申请日：2012-02-23

    Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    IPC: A61K38/00 ,  C07K16/46

    CPC classification number: C07K16/40 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/1796 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P21/00 ,  C07K14/71 ,  C07K2319/30 ,  C12N5/0602

    Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF 11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.

    Abstract translation: 在某些方面，本发明提供通过施用ActRIIB信号传导途径的拮抗剂来增加产热脂肪细胞（例如，棕色脂肪细胞或其他表达UCP-1的脂肪细胞）的组合物和方法。 这些拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗肌生成抑制素抗体，抗GDF3抗体，抗-Nodal，抗激活素和抗GDF11抗体。 可以通过引起生热脂肪细胞的增加来治疗各种代谢和其它疾病。

    Variants derived from ActRIIB and uses therefor
    75.
    发明授权
    Variants derived from ActRIIB and uses therefor 有权
    衍生自ActRIIB的变体并用于此

    公开(公告)号：US08343933B2

    公开(公告)日：2013-01-01

    申请号：US12893976

    申请日：2010-09-29

    Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    IPC: A61K38/16 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/18 ,  C07K2319/30 ,  C07K2319/70

    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

    Abstract translation: 在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。 本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。 本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。

    Method and system for managing clustered and non-clustered storage systems
    76.
    发明授权
    Method and system for managing clustered and non-clustered storage systems 有权
    用于管理群集和非群集存储系统的方法和系统

    公开(公告)号：US08271556B1

    公开(公告)日：2012-09-18

    申请号：US13241000

    申请日：2011-09-22

    Applicant: Raja Shekar ,  Ravindra Kumar ,  Kartik Kumar

    Inventor： Raja Shekar ,  Ravindra Kumar ,  Kartik Kumar

    IPC: G06F17/30 ,  G06F12/00

    CPC classification number: G06F17/30067 ,  H04L12/1435 ,  H04L41/12 ,  H04L41/22 ,  H04L43/0817 ,  H04L67/1097

    Abstract: Method and system for managing a storage environment having a cluster based storage system and a non-cluster based storage system is provided. A management application collects information regarding components of both the cluster based storage system and the non-cluster based storage system. A layout having a plurality of data structures is generated and maintained by the management application. The data structures include information regarding the components and their relationships with each other, if any. The layout is used for responding to user requests and presenting an integrated view of the storage environment on a display device with selectable options for selecting the cluster based storage system components and the non-cluster based storage system components.

    Abstract translation: 提供了一种用于管理具有基于群集的存储系统和基于非群集的存储系统的存储环境的方法和系统。 管理应用程序收集有关基于群集的存储系统和基于非群集的存储系统的组件的信息。 具有多个数据结构的布局由管理应用程序生成和维护。 数据结构包括关于组件及其彼此之间的关系的信息（如果有的话）。 该布局用于响应用户请求，并在显示设备上呈现存储环境的集成视图，其具有用于选择基于群集的存储系统组件和基于非群集的存储系统组件的可选择选项。

    Methods for increasing adiponectin in a patient in need thereof
    80.
    发明授权
    Methods for increasing adiponectin in a patient in need thereof 有权
    在有需要的患者中增加脂连蛋白的方法

    公开(公告)号：US08138142B2

    公开(公告)日：2012-03-20

    申请号：US12657146

    申请日：2010-01-13

    Applicant: Jasbir Seehra ,  Ravindra Kumar ,  Jennifer Lachey ,  Alan Koncarevic

    Inventor： Jasbir Seehra ,  Ravindra Kumar ,  Jennifer Lachey ,  Alan Koncarevic

    IPC: A61K38/00 ,  C07K16/46

    CPC classification number: C07K16/40 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/179 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/30

    Abstract: In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.

    Abstract translation: 在某些方面，本发明提供了通过施用ActRIIB信号通路的拮抗剂来增加有需要的患者中的脂连蛋白的组合物和方法。 此类拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗激活素A和/或B抗体，抗肌生成抑制素抗体，抗GDF3抗体和抗BMP7抗体。 还提供了用于改善一种或多种不期望的抗雄激素治疗效果的方法，包括肌肉损失，骨丢失，增加的肥胖和/或增加的胰岛素抵抗。 可以通过引起循环中脂联素浓度的增加来治疗多种疾病。

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