公开(公告)号：US20090023226A1

公开(公告)日：2009-01-22

申请号：US12021074

申请日：2008-01-28

Applicant: M. Amin Arnaout ,  Rui Li ,  Jian-Ping Xiong

Inventor： M. Amin Arnaout ,  Rui Li ,  Jian-Ping Xiong

IPC: G01N33/566 ,  C07K16/18

CPC classification number: C07K14/70553 ,  A61K38/00 ,  C07K14/70546 ,  C07K16/2845

Abstract: Polypeptides comprising all or part of a variant integrin α subunit A domain and its flanking region are described. In solution or in membrane-associated form, the A domain polypeptides of the invention exists predominantly in a high affinity conformation. In the polypeptides of the invention, referred to as variant integrin polypeptides, a crucial isoleucine or glutamic acid residue is altered. For example, the glutamic acid can be either deleted or replaced with different amino acids residue, e.g., glutamine, aspartic acid, or alanine The variant integrin polypeptides of the invention selectively impair binding of activation-dependent ligands, but not independent ligands. They are useful in screening assays for the identification of molecules that enhance binding of variant polypeptides with impaired binding. In addition, they are useful in distinguishing between activation-dependent ligands and activation-independent ligands. They are also useful for generating antibodies, e.g., monoclonal antibodies, which bind to the impaired form of an integrin. Some such antibodies recognize an epitope that is either not present or not accessible on an integrin that is in the high affinity conformation. The variant integrin polypeptides of the invention can be derived from any integrin α subunit that could be used therapeutically.

Abstract translation: 描述了包含全部或部分变体整联蛋白α亚基A结构域及其侧翼区的多肽。 在溶液或膜相关形式中，本发明的A结构域多肽主要存在于高亲和力构象中。 在本发明的多肽中，称为变体整联蛋白多肽，关键的异亮氨酸或谷氨酸残基被改变。 例如，谷氨酸可被删除或被不同氨基酸残基替代，例如谷氨酰胺，天冬氨酸或丙氨酸。本发明的变体整联蛋白多肽选择性地损害活化依赖性配体但不是独立配体的结合。 它们可用于鉴定增强变异多肽与受损结合的结合的分子的筛选分析。 此外，它们可用于区分活化依赖性配体和与激活无关的配体。 它们也可用于产生结合受损形式的整联蛋白的抗体，例如单克隆抗体。 一些这样的抗体识别在高亲和力构象的整联蛋白上不存在或不可接近的表位。 本发明的变体整联蛋白多肽可以衍生自可以在治疗上使用的任何整联蛋白α亚基。

公开(公告)号：US07323552B2

公开(公告)日：2008-01-29

申请号：US10144259

申请日：2002-05-10

Applicant: M. Amin Arnaout ,  Rui Li ,  Jian-Ping Xiong

Inventor： M. Amin Arnaout ,  Rui Li ,  Jian-Ping Xiong

IPC: C07K1/107 ,  A61K38/04 ,  G01N33/53

CPC classification number: C07K14/70553 ,  A61K38/00 ,  C07K14/70546 ,  C07K16/2845

Abstract: Polypeptides comprising all or part of a variant integrin α subunit A domain and its flanking region are described. In solution or in membrane-associated form, the A domain polypeptides of the invention exists predominantly in a high affinity conformation. In the polypeptides of the invention, referred to as variant integrin polypeptides, a crucial isoleucine or glutamic acid residue is altered. For example, the glutamic acid can be either deleted or replaced with different amino acids residue, e.g., glutamine, aspartic acid, or alanine The variant integrin polypeptides of the invention selectively impair binding of activation-dependent ligands, but not independent ligands. They are useful in screening assays for the identification of molecules that enhance binding of variant polypeptides with impaired binding. In addition, they are useful in distinguishing between activation-dependent ligands and activation-independent ligands. They are also useful for generating antibodies, e.g., monoclonal antibodies, which bind to the impaired form of an integrin. Some such antibodies recognize an epitope that is either not present or not accessible on an integrin that is in the high affinity conformation. The variant integrin polypeptides of the invention can be derived from any integrin α subunit that could be used therapeutically.

Abstract translation: 描述了包含全部或部分变体整联蛋白α亚基A结构域及其侧翼区的多肽。 在溶液或膜相关形式中，本发明的A结构域多肽主要存在于高亲和力构象中。 在本发明的多肽中，称为变体整联蛋白多肽，关键的异亮氨酸或谷氨酸残基被改变。 例如，谷氨酸可被删除或被不同氨基酸残基替代，例如谷氨酰胺，天冬氨酸或丙氨酸。本发明的变体整联蛋白多肽选择性地损害活化依赖性配体但不是独立配体的结合。 它们可用于鉴定增强变异多肽与受损结合的结合的分子的筛选分析。 此外，它们可用于区分活化依赖性配体和与激活无关的配体。 它们也可用于产生结合受损形式的整联蛋白的抗体，例如单克隆抗体。 一些这样的抗体识别在高亲和力构象的整联蛋白上不存在或不可接近的表位。 本发明的变体整联蛋白多肽可以衍生自可以在治疗上使用的任何整联蛋白α亚基。

公开(公告)号：USD1072047S1

公开(公告)日：2025-04-22

申请号：US29890736

申请日：2023-04-26

Applicant: Rui Li

Designer： Rui Li

公开(公告)号：USD1001889S1

公开(公告)日：2023-10-17

申请号：US29800116

申请日：2021-07-19

Applicant: Rui Li

Designer： Rui Li

Abstract: FIG. 1 is a perspective view of the business card holder showing my new design;
FIG. 2 is a perspective view thereof from another angle;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side elevational view thereof;
FIG. 6 is a right side elevational view thereof;
FIG. 7 is a top plan view of thereof; and,
FIG. 8 is a bottom plan view of thereof.

公开(公告)号：US20210116342A1

公开(公告)日：2021-04-22

申请号：US16658033

申请日：2019-10-19

Applicant: Jun Liu ,  Pengliang Yang ,  Runfeng Li ,  Rui Li ,  Haijian Zhang ,  Yaozhong Hu

Inventor： Jun Liu ,  Pengliang Yang ,  Runfeng Li ,  Rui Li ,  Haijian Zhang ,  Yaozhong Hu

IPC: G01N3/10 ,  G01N3/22 ,  G01N3/20 ,  F15B7/06

Abstract: The invention discloses a mechanical performance testing device and a hydraulic control system thereof. The instrument comprises a base, a fixing means, a first testing means and a second testing means. Wherein the base is connected with the fixing means, each of the first testing means and the second testing means is configured to cause the fixing means to move in various directions. And the instrument can simultaneously apply multiple forces and torques on the element, such that the different stiffness characteristics of the element can be tested simultaneously. The hydraulic control system comprises fuel tank, oil pump and control valves. And the fuel tank, the oil pump and the control valves connect successively. The mechanical performance testing device with hydraulic control system can improve efficiency of the test, reduce the working intensity of inspector, increase the security in detection process, and improve the accuracy of measurement results.

公开(公告)号：US09255868B2

公开(公告)日：2016-02-09

申请号：US13979829

申请日：2012-05-03

Applicant: Rui Li ,  Miao Qian ,  Minbo Yu ,  Guoyong Li ,  Zhihua Zhu ,  Hongyun Yu ,  Qun Yuan

Inventor： Rui Li ,  Miao Qian ,  Minbo Yu ,  Guoyong Li ,  Zhihua Zhu ,  Hongyun Yu ,  Qun Yuan

IPC: G01F15/14 ,  G01N3/26 ,  G01N3/20 ,  G01N3/28

CPC classification number: G01N3/26 ,  G01N3/20 ,  G01N3/28 ,  G01N2203/0264 ,  G01N2203/028

Abstract: It is provided a dedicated winding tester for composite wire rod-type specimens for effectively measuring the minimum winding radius of the wire rod-type specimens being made with carbon fiber or glass fiber reinforced composites in various diameters or textures via automatically gripping specimens, tightly winding, and sequentially proceeding sustained load in time, thereby supplying test data and design consideration in actual use and transport of the wire rod-type specimens being made of carbon fiber or glass fiber reinforced composites that comprises a shield, a specimen receiver and a winding device being arranged within said shield, as well as a programmable controller being arranged outside the shield.

Abstract translation: 为复合线材型样品提供专用卷绕测试仪，用于通过自动夹紧样品，紧密缠绕，有效测量各种直径或纹理的碳纤维或玻璃纤维增​​强复合材料制成的线材型样品的最小卷绕半径 ，并且及时依次进行持续负载，从而在实际使用和运输由碳纤维或玻璃纤维增​​强复合材料制成的线材型样品的实际使用和运输中提供测试数据和设计考虑因素，其包括屏蔽件，样品接收器和卷绕装置 布置在所述屏蔽内，以及设置在屏蔽外部的可编程控制器。

公开(公告)号：US20150052143A1

公开(公告)日：2015-02-19

申请号：US13966160

申请日：2013-08-13

Applicant: Ming Liu ,  Suresh Raman ,  Rui Li

Inventor： Ming Liu ,  Suresh Raman ,  Rui Li

IPC: G06F17/30

CPC classification number: G06F17/30601 ,  G06F17/30705 ,  G06F17/3089 ,  G06Q30/00 ,  G06Q30/0601

Abstract: Techniques for categorizing item listings based on parsing item listing titles are described. According to various embodiments, listing titles of one or more item listings on a marketplace website are accessed, the item listings being associated with a particular product category in a product category structure of the marketplace website. Words in each of the listing titles may then be converted to semantic tokens in a token symbol space, based on a tokenization process. Thereafter, n-gram modeling may be performed on the tokens corresponding to each of the listing titles of the item listings in the particular product category. One or more dominant n-gram models associated with the listing titles of the item listings in the particular product category may then be identified.

Abstract translation: 描述了基于解析项目列表标题对项目列表进行分类的技术。 根据各种实施例，访问在市场网站上列出一个或多个项目列表的标题，该项目列表与市场网站的产品类别结构中的特定产品类别相关联。 然后，可以基于标记化处理将每个列表标题中的单词转换为令牌符号空间中的语义令牌。 此后，可以对与特定产品类别中的项目列表的每个列表标题相对应的令牌执行n元建模。 然后可以识别与特定产品类别中的商品列表的列表标题相关联的一个或多个主要的n-gram模型。

公开(公告)号：US08844040B2

公开(公告)日：2014-09-23

申请号：US12409322

申请日：2009-03-23

Applicant: James Harris ,  Rui Li ,  Arkesh Kumar ,  Ravindranath Thakur ,  Puneet Agarwal ,  Akshat Choudhary ,  Punit Gupta

Inventor： James Harris ,  Rui Li ,  Arkesh Kumar ,  Ravindranath Thakur ,  Puneet Agarwal ,  Akshat Choudhary ,  Punit Gupta

IPC: H04L29/06

CPC classification number: H04L63/0876 ,  G06F21/31 ,  G06F21/53 ,  G06F2009/4557 ,  H04L63/08 ,  H04L63/0884 ,  H04L63/10 ,  H04L63/105 ,  H04L63/166 ,  H04L63/20 ,  H04L67/2814

Abstract: The present invention provides a system and method of managing traffic traversing an intermediary based on a result of end point auditing. An authentication virtual server of an intermediary may determine a result of an end point analysis scan of a client. Responsive to the determination, the traffic management virtual server can obtain the result from the authentication virtual server. Further, the traffic management virtual server may apply the result in one or more traffic management policies to manage network traffic of a connection of the client traversing the intermediary. In some embodiments, the authentication virtual server may receive one or more expressions evaluated by the client. The one or more expressions identifies one or more attributes of the client. The traffic management virtual server can also determine a type of compression or encryption for the connection based on applying the one or more traffic management policies using the result.

Abstract translation: 本发明提供了一种基于终端审计结果来管理遍历中间人的流量的系统和方法。 中介的认证虚拟服务器可以确定客户端的终点分析扫描的结果。 响应确定，流量管理虚拟服务器可以从认证虚拟服务器获取结果。 此外，流量管理虚拟服务器可以将结果应用于一个或多个流量管理策略中，以管理遍历中间件的客户端的连接的网络流量。 在一些实施例中，认证虚拟服务器可以接收由客户端评估的一个或多个表达式。 一个或多个表达式标识客户端的一个或多个属性。 流量管理虚拟服务器还可以基于使用结果应用一个或多个流量管理策略来确定连接的压缩或加密的类型。

公开(公告)号：US20140271563A1

公开(公告)日：2014-09-18

申请号：US14355744

申请日：2012-11-02

Applicant: Sylvie Claudette Alonso ,  Rui Li ,  Camille Locht

Inventor： Sylvie Claudette Alonso ,  Rui Li ,  Camille Locht

IPC: A61K35/74

CPC classification number: A61K35/74 ,  A61K39/39 ,  A61K2039/10 ,  A61K2039/522 ,  A61K2039/577 ,  C07K14/235 ,  C07K14/245 ,  C12N1/36

Abstract: Described herein are compositions, vaccines, and methods that include use of a mutated Bordetella strain against allergic diseases such as asthma and skin inflammation. Also described are kits. Other compositions, vaccines, and methods are also described.

Abstract translation: 本文描述的是组合物，疫苗和方法，其包括使用突变的博德特氏菌菌株对抗过敏性疾病如哮喘和皮肤炎症。 还描述了套件。 还描述了其它组合物，疫苗和方法。

公开(公告)号：US08786407B2

公开(公告)日：2014-07-22

申请号：US13208284

申请日：2011-08-11

Applicant: Xue Wu Liu ,  Rui Li

Inventor： Xue Wu Liu ,  Rui Li

IPC: G06K7/01

CPC classification number: B65D19/44 ,  B65D19/001 ,  B65D19/38 ,  B65D2203/10 ,  B65D2519/00034 ,  B65D2519/00069 ,  B65D2519/00273 ,  B65D2519/00288 ,  B65D2519/00323 ,  B65D2519/00338 ,  B65D2519/00572 ,  B65D2519/00985 ,  Y02W30/807

Abstract: An universal and reusable RFID system comprises an universal and reusable RFID reader, an universal and reusable RFID data carrier, a universal and reusable RFID neutral tag, a RFID neutral tag equipped collapsible and reusable pallet and a RFID neutral tag equipped collapsible and reusable box. In various embodiments, the universal and reusable RFID system is used for data collection, data comparison, data confirmation and data combination under all conditions in the supply chain and logistics management. A “bank-like” system is further used for all components of the universal and reusable RFID system to be efficiently supplied for use and collected for further application.

Abstract translation: 通用和可重复使用的RFID系统包括通用和可重复使用的RFID读取器，通用和可重复使用的RFID数据载体，通用和可重复使用的RFID中性标签，装备有可折叠和可重复使用的托盘的RFID中性标签和装备有可折叠和可重复使用的盒子的RFID中性标签。 在各种实施例中，通用和可重复使用的RFID系统用于在供应链和物流管理的所有条件下的数据收集，数据比较，数据确认和数据组合。 进一步将“银行式”系统用于通用和可重复使用的RFID系统的所有组件，以便有效地提供使用和收集以供进一步应用。