公开(公告)号：US20210405064A1

公开(公告)日：2021-12-30

申请号：US17476971

申请日：2021-09-16

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development

Inventor： Ying Mei ,  Jia Jia ,  Chung-Jen James Chou

IPC: G01N33/68 ,  C07K7/06 ,  C07K7/08 ,  A61P9/10 ,  G01N33/74 ,  C07K14/78 ,  C07K17/02 ,  C07K14/71 ,  C07K14/755 ,  C07K14/52 ,  C07K14/75 ,  C07K14/705

Abstract: The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.

公开(公告)号：US11207154B2

公开(公告)日：2021-12-28

申请号：US16469811

申请日：2019-03-12

Applicant: MUSC Foundation for Research Development

Inventor： Walter Renne ,  Zachary Evans

IPC: A61C1/08 ,  B33Y80/00 ,  A61C8/00 ,  A61B17/17 ,  A61C9/00 ,  B33Y10/00 ,  B33Y50/02 ,  A61B34/10 ,  B29C64/10 ,  A61B18/20 ,  A61C1/00 ,  G06T13/20 ,  A61C3/02 ,  A61B17/16 ,  G06T1/00

Abstract: Provided herein are surgical guides with internal channels for irrigation cooling. In one embodiment, an apparatus for guiding a surgical instrument includes a proximal side and a distal side. A first channel is configured to guide a material removal device, where the first channel extends from the proximal side of the apparatus to the distal side of the apparatus. A second channel configured to direct irrigation fluid, where the second channel extends from the proximal side of the of the apparatus to the distal side of the apparatus. The first channel is separate from the second channel. A method of performing a surgical procedure and a method of manufacturing a surgical guide are also disclosed. In certain embodiments, the surgical guides may be manufactured via additive manufacturing processes, including for example, three-dimensional printing processes.

公开(公告)号：US11191851B2

公开(公告)日：2021-12-07

申请号：US16572260

申请日：2019-09-16

Applicant: MUSC Foundation for Research Development ,  The United States Government as Represented by the Department of Veterans Affairs ,  The Regents of the University of Colorado, a body corporate ,  Universitat de Barcelona

Inventor： Stephen Tomlinson ,  V. Michael Holers ,  Pablo Engel

IPC: A61K49/00 ,  A61K51/10 ,  C07K16/18 ,  G01N33/569 ,  A61K49/16 ,  C07K16/28 ,  G01N33/534

Abstract: Provided herein, inter alia, are compositions and methods of using the same for detecting complement activation.

公开(公告)号：US20210338277A1

公开(公告)日：2021-11-04

申请号：US17376645

申请日：2021-07-15

Applicant: MUSC Foundation for Research Development

Inventor： Stephen Kalhorn ,  Ryan Kellogg ,  Joe Ruscito

IPC: A61B17/34 ,  A61B17/00

Abstract: The present invention provides minimally invasive subdural evacuating systems and methods of use thereof. The subdural evacuating systems include a cutting component and a rod component, wherein the rod component provides an external physical indicator that the surface of the dura mater has been reached, permitting the cutting component to accurately pierce the dura mater with minimal to no risk of damaging any adjacent anatomy.

公开(公告)号：US11147646B2

公开(公告)日：2021-10-19

申请号：US16220242

申请日：2018-12-14

Applicant: MUSC Foundation for Research Development

Inventor： Raymond Turner ,  Alex Spiotta ,  Aquilla Turk ,  Imran Chaudry ,  Mark Semler

IPC: A61B90/10 ,  A61B90/11 ,  A61B17/34 ,  A61B90/00

Abstract: A cranial anchor system configured to attach to an opening in a cranium includes an anchor member. The anchor member has a middle anchor portion and a lower anchor portion coupled to and disposed in a downward direction relative to the middle anchor portion. The lower anchor portion has a plurality of contact members, each of which have a leg that extends at least partially in the downward direction, a tab connected to the leg, and a rib disposed between the leg and the tab. The system further includes an outer sheath and an inner sheath disposed within the outer sheath and slidable relative to the outer sheath.

公开(公告)号：US11097036B2

公开(公告)日：2021-08-24

申请号：US15752404

申请日：2016-08-17

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Stephen P. Kalhorn ,  Mark E. Semler

IPC: A61B90/70 ,  A61M1/00 ,  A61C17/06

Abstract: A declogging assembly (20) is configured for use with a suction conduit (10). The suction conduit has a head (14) at a first end (15) and a vacuum tube connection (16) at a second end (17). The assembly includes a body (30). The body defines a first aperture (32), a second aperture (34), and a third aperture (36). The assembly also includes a plug (40) disposed within the body (30). The plug has a surface (42) configured to contact the head (14) of the suction conduit (10) so as to move the plug from a first position, in which the first aperture (32) is in fluid communication with the second aperture (34), to a second position, in which the first aperture (32) is in fluid communication with the third aperture (36). The assembly (20) also includes a biasing member (50) configured to bias the plug into the first position.

公开(公告)号：US20210196771A1

公开(公告)日：2021-07-01

申请号：US17268656

申请日：2019-08-16

Applicant: SYSTEMS ONCOLOGY, LLC ,  MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Jeff KIEFER ,  Ramon MORENO ,  Spyro MOUSSES ,  Eric BARTEE

IPC: A61K35/768 ,  C07K14/705 ,  C07K14/54 ,  C07K14/55 ,  A61K45/06 ,  C12N7/00 ,  A61P35/00

Abstract: The present disclosure provides a recombinant oncolytic virus engineered to express a soluble form of an immune checkpoint protein. In certain aspects, the oncolytic vims is a replication competent virus such as myxoma vims. Methods of cancer treatment comprising administering the recombinant oncolytic virus expressing the soluble form of the immune checkpoint protein are also provided.

公开(公告)号：US11007254B2

公开(公告)日：2021-05-18

申请号：US16342853

申请日：2017-10-17

Applicant: MUSC Foundation For Research Development ,  United States Government as Represented by the Department of Veteran Affairs

Inventor： Stephen Tomlinson ,  DeAnna Adkins ,  Ali Alawieh

IPC: A61K38/00 ,  A61K38/57 ,  C07K16/18 ,  A61K38/17 ,  A61K38/49 ,  A61P25/00 ,  A61K39/00

Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.

公开(公告)号：US20200283728A1

公开(公告)日：2020-09-10

申请号：US16479740

申请日：2018-01-25

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Chrystal M. PAULOS ,  Kinga MAJCHRZAK ,  Jacob S. BOWERS

IPC: C12N5/0783 ,  A61K35/17 ,  A61P35/00

Abstract: Provided herein are methods for the production of enhanced ICOS-stimulated Th17 cells by co-stimulation with inducible coactivator (ICOS) and an inhibitor of POK/Akt signaling and/or an inhibitor of Wnt/β-catenin signaling. Further provided are methods for treatment of cancer by administration of the enhanced ICOS-stimulated Th17 cells as an adoptive T cell therapy.

公开(公告)号：USD892325S1

公开(公告)日：2020-08-04

申请号：US29688721

申请日：2019-04-24

Applicant: MUSC Foundation for Research Development

Designer： Andrea Abbott ,  Matthew Roberts