公开(公告)号：US4889714A

公开(公告)日：1989-12-26

申请号：US279360

申请日：1988-12-02

申请人： Perry A. Ratcliff

发明人： Perry A. Ratcliff

IPC分类号： A01N59/00 ,  A61K8/19 ,  A61K8/22 ,  A61K33/20 ,  A61L12/10 ,  A61Q11/00 ,  A61Q11/02 ,  C11D3/00 ,  C11D7/02

CPC分类号： C11D7/02 ,  A01N59/00 ,  A61K33/20 ,  A61K8/19 ,  A61K8/22 ,  A61L12/102 ,  A61Q11/00 ,  A61Q11/02 ,  C11D3/0078

摘要： The use of stabilized chlorine dioxide or chlorine dioxide in aqueous solution as a composition to reduce or prevent plaque formation and treatment of oral diseases ecologically plaque dependent, such as gingivitis and periodontitis, is disclosed. Preferred concentrations are in the range of 0.005% to 0.2% and the chlorine dioxide may be in the form of a rinse, a wash, a soak or a dentifrice.

摘要翻译： 公开了在水溶液中使用稳定的二氧化氯或二氧化氯作为组合物以减少或预防斑块形成和治疗生态上斑块依赖性的口腔疾病，例如牙龈炎和牙周炎。 优选的浓度在0.005％至0.2％的范围内，并且二氧化氯可以是冲洗，洗涤，浸泡或洁齿剂的形式。

公开(公告)号：US4654208A

公开(公告)日：1987-03-31

申请号：US700745

申请日：1985-02-12

申请人： Richard F. Stockel ,  Murray Jelling

发明人： Richard F. Stockel ,  Murray Jelling

IPC分类号： A01N59/00 ,  A61L12/10 ,  A61L12/14 ,  A01N43/58 ,  A01N33/12 ,  A01N37/52 ,  A61K31/74

CPC分类号： A61L12/145 ,  A01N59/00 ,  A61L12/102

摘要： An anti-microbial composition comprises an aqueous solution of a germicidal polymeric nitrogen compound and an oxidizing agent which potentiates the activity of the compound. The polymeric nitrogen compound includes a germicidal quaternary ammonium compound or a polyguanide compound. The oxidizing agent has a standard reduction potential between 0.85 and 2.0 volts, is soluble in water, non-toxic and enhances the activity germicidal of the nitrogen polymer at low concentrations. Suitable oxidizing agents include halogen oxides, oxyhalogens, halogens, and inorganic and organic peroxides.

摘要翻译： 抗微生物组合物包含杀菌性聚合氮化合物的水溶液和增强化合物活性的氧化剂。 聚合氮化合物包括杀菌季铵化合物或聚胍化合物。 氧化剂的标准还原电位在0.85和2.0伏特之间，可溶于水，无毒，并提高氮聚合物在低浓度下的杀菌活性。 合适的氧化剂包括卤素氧化物，卤代卤素，卤素和无机和有机过氧化物。

公开(公告)号：US4499077A

公开(公告)日：1985-02-12

申请号：US471011

申请日：1983-03-01

申请人： Richard F. Stockel ,  Murray Jelling

发明人： Richard F. Stockel ,  Murray Jelling

IPC分类号： A01N59/00 ,  A61L12/10 ,  A61L12/14 ,  A61K33/20 ,  A01N33/12 ,  A61K31/14

CPC分类号： A61L12/145 ,  A01N59/00 ,  A61L12/102

摘要： An anti-microbial composition is provided comprising an aqueous solution of an oxyhalogen compound and a polymeric germicide. The oxyhalogen compound is preferably stabilized chlorine dioxide and the polymeric germicide is preferably a quaternary ammonium compound such as a copolymer of at least one difunctional tertiary amine and a dihalo organic compound such as 1,4-dihalo-2-butene, a copolymer of at least one difunctional tertiary amine, at least one monofunctional tertiary amine and a dihalo organic compound such as 1,4-dihalo-2-butene, or a polyguanide such as hydrochloride salt of poly(hexamethylene biguanide). The anti-microbial composition thus formed is used for the treatment of soft contact lenses to disinfect the same with an optimum effect while minimizing the irritant possibilities thereof and also minimizing absorption of the composition into the porous and hydrophilic surfaces of soft contact lenses such that there is a minimal release of absorbed substances after treatment.

摘要翻译： 提供了包含卤氧化合物和聚合杀菌剂的水溶液的抗微生物组合物。 卤代卤化合物优选是稳定的二氧化氯，并且聚合杀菌剂优选为季铵化合物，例如至少一种二官能叔胺和二卤代有机化合物如1,4-二卤代-2-丁烯的共聚物， 至少一个双官能叔胺，至少一个单官能叔胺和二卤代有机化合物如1,4-二卤代-2-丁烯，或聚胍如聚（六亚甲基双胍）的盐酸盐。 如此形成的抗微生物组合物用于治疗软性隐形眼镜以最佳效果对其进行消毒，同时最小化其刺激性可能性，并且还使组合物吸收到软性隐形眼镜的多孔和亲水表面中，使得 是治疗后吸收物质的最小释放。

公开(公告)号：US4031209A

公开(公告)日：1977-06-21

申请号：US582762

申请日：1975-06-02

申请人： Joseph Zenon Krezanoski

发明人： Joseph Zenon Krezanoski

IPC分类号： A61K33/22 ,  A61L12/10 ,  C11D3/00 ,  A01N11/00 ,  A61K33/18

CPC分类号： A61L12/105 ,  A61K33/22 ,  C11D3/0078

摘要： An aqueous solution suitable for dissipating, at a controlled rate, available iodine contained in an iodophor is disclosed. The aqueous dissipating solution contains sorbic acid or soluble salts thereof and ethylenediaminetetraacetic acid or soluble salts thereof. Preferably, the dissipating solution also contains an ammonium, alkali metal, or alkaline earth metal salt of a boron oxyacid. Also disclosed are techniques for sterilizing contact lenses and sterile solutions, suitable for maintaining sterility of a previously sterilized object, comprising admixtures of the dissipating solutions with iodophor solutions.

摘要翻译： 公开了一种适于以受控速率消散碘伏中含有的可用碘的水溶液。 水分散溶液含有山梨酸或其可溶性盐和乙二胺四乙酸或其可溶性盐。 优选地，消散溶液还含有含硼酸的铵，碱金属或碱土金属盐。 还公开了用于消毒隐形眼镜和无菌溶液的技术，其适用于维持先前灭菌的物体的无菌性，其包括消散溶液与碘伏溶液的混合物。

公开(公告)号：US3911107A

公开(公告)日：1975-10-07

申请号：US31579372

申请日：1972-12-18

申请人： FLOW PHARMA INC

发明人： KREZANOSKI JOSEPH Z

IPC分类号： A61K33/22 ,  A61L12/10 ,  C11D3/00 ,  A61K31/74 ,  A61K33/18

CPC分类号： A61K33/22 ,  A61L12/105 ,  C11D3/0078 ,  A61K33/18 ,  A61K31/765

摘要： An aqueous, antiseptic, iodophor solution is provided containing iodine, a water soluble iodide salt or hydriotic acid, polyvinyl alcohol and boric acid. The iodophor solution may be employed to sterilize a broad range of animate and inanimate objects, including contact lenses. Additionally, the iodophor solution, or similar iodophor solutions which do not contain boric acid, may be employed in visual temperature sensing devices. The visual temperature sensing devices comprise a transparent vessel containing the iodophor solution. Also disclosed is an aqueous solution for dissipating, at a controlled rate, available iodine contained in an iodophor. The aqueous dissipating solution contains sorbic acid or soluble salts thereof and ethylenediaminetetraacetic acid or soluble salts thereof.

摘要翻译： 提供含有碘，水溶性碘盐或氢碘酸，聚乙烯醇和硼酸的含水，防腐，碘伏溶液。 碘伏溶液可用于消除广泛范围的动画和无生命物体，包括隐形眼镜。 此外，可以在视觉温度感测装置中使用碘伏溶液或不含硼酸的类似碘伏溶液。 视觉温度感测装置包括含有碘伏溶液的透明容器。 还公开了一种水溶液，其以受控的速率耗散碘伏存在的可用碘。 水分散溶液含有山梨酸或其可溶性盐和乙二胺四乙酸或其可溶性盐。

公开(公告)号：US3876768A

公开(公告)日：1975-04-08

申请号：US44664374

申请日：1974-02-28

申请人： HYDROPHILICS INT INC

发明人： BLANK IZHAK

IPC分类号： A61L12/10 ,  A01N11/00

CPC分类号： A61L12/107

摘要： Soft, hydrophilic acrylate and methacrylate copolymer materials are sterilized by immersing them in a solution containing small, but effective amounts of a material which releases active halogen in solution, but is non-damaging to the eye in concentrations effective for sterilization. A particularly effective material is chlorinated trisodium phosphate. The concentrataion of the sterilant material should be such that it releases halogen in amounts of from about 2 parts per million to 250 parts per million. The technique is particularly useful for sterilization of soft, hydrophilic acrylate and methacrylate contact lenses.