SESQUITERPENOID DERIVATIVE AND USE THEREOF IN PREPARING BROAD-SPECTRUM ANTIVIRAL DRUG

    公开(公告)号:US20240270754A1

    公开(公告)日:2024-08-15

    申请号:US18625188

    申请日:2024-04-02

    Inventor: Min XU Shaoxing DAI

    CPC classification number: C07D493/10 A61K31/35 A61P31/14

    Abstract: A sesquiterpenoid derivative and use thereof in preparing a broad-spectrum antiviral drug provided. The sesquiterpenoid derivative can stimulate heterogeneous nuclear ribonucleoprotein A2/B1, activate the cell signal pathway of TANK-binding kinase 1-interferon regulatory factor 3, and increase the expression and secretion of endogenous type I interferon. As a result, it can inhibiting various viruses and can be used as a broad-spectrum antiviral drug for preventing or treating various viral infectious diseases and symptoms, including Covid-19, vesicular stomatitis virus VSV-G, AIDS virus, hepatitis C virus, Japanese encephalitis virus, influenza virus, poliovirus, Coxsackie virus, dengue virus, rotavirus, tobacco mosaic virus, measles virus, mumps virus, Ebola virus, Marburg virus, herpes virus and adenovirus. Sesquiterpenoid derivatives can be made as a raw material into oral dosage form such as tablet, capsule and dripping pill, or clinically acceptable pharmaceutical preparation such as inhalant and injection.

    NONLINEAR OXYGEN-ENRICHED INJECTION METHOD BASED ON CHAOTIC MAPPING AND ELECTRONIC DEVICE THEREOF

    公开(公告)号:US20240102129A1

    公开(公告)日:2024-03-28

    申请号:US18164476

    申请日:2023-02-03

    CPC classification number: C22B9/05

    Abstract: A nonlinear oxygen-enriched injection method based on chaotic mapping and electronic device is disclosed, including: obtaining a chaotic gas injection volume corresponding to a current speed change period according to a chaotic mapping value corresponding to the current speed change period and a peak gas injection volume in an oxygen-enriched injection process; determining a rotational speed of a fan blade in a fan component corresponding to the current speed change period according to the chaotic gas injection volume; updating a rotational speed of a direct current (DC) motor in the fan component corresponding to the current speed change period according to the rotational speed of the fan blade in the fan component, and driving the fan blade to rotate according to an updated rotational speed of the DC motor, so as to update an air output of the fan component. The above operations are repeated until a last stage.

    Device for continuous treatment of materials containing volatile components

    公开(公告)号:US11801552B2

    公开(公告)日:2023-10-31

    申请号:US17928471

    申请日:2022-03-24

    CPC classification number: B22D43/007

    Abstract: Disclosed is a device for continuous treatment of materials containing volatile components, which belongs to the field of pyrometallurgical equipment. The device includes a feeding unit, a heating unit, a slag raking unit and a slag collecting unit. The feeding unit is configured to feed the materials with a push rod or in a spiral mode. The heating unit is provided with a square furnace body, and a first slag raking port is provided in the lower part of the furnace body. The slag collecting unit is provided with a slag discharging port at the lower portion thereof, is provided with a slag smashing port at the sidewall thereof, and is provided with a viewing port at the top thereof. The slag collecting unit and the heating unit are connected through a pipeline, thus achieving the pressure balance of the whole device during operation.

    Method for Treating Arsenic-Containing Flue Gas

    公开(公告)号:US20230080405A1

    公开(公告)日:2023-03-16

    申请号:US17546786

    申请日:2021-12-09

    Abstract: A method for treating arsenic-containing flue gas is disclosed. In the method, the arsenic-containing flue gas is subjected to a dry pre-dedusting treatment, and the dedusted flue gas is pre-cooled and then introduced into a vortex quenching system. The arsenic-containing flue gas is divided into high-temperature flue gas and low-temperature flue gas through the vortex quenching system. The outlet temperature of the low-temperature flue gas is dropped below the desublimation temperature of gaseous arsenic trioxide. The low-temperature flue gas is subjected to a gas-solid separation to obtain solid arsenic trioxide and treated flue gas.

    Method for ammonium-enhanced flue gas desulfurization by using red mud slurry

    公开(公告)号:US11535572B2

    公开(公告)日:2022-12-27

    申请号:US16821043

    申请日:2020-03-17

    Abstract: The present invention discloses a method for ammonium-enhanced flue gas desulfurization (FGD) by using red mud slurry. The method specifically includes: crushing red mud, sieving the crushed red mud, slurrying the red mud, conducting aeration treatment, adding an ammonium salt and/or ammonia, and conducting natural sedimentation to obtain pretreated red mud slurry and pretreated red mud liquor; adding an ammonium salt and/or ammonia to the slurry, adding water and conducting uniform mixing, conducting pre-FGD, conducting deep desulfurization on treated flue gas by using the pretreated red mud liquor, and directly discharging desulfurized flue gas; and charging the pretreated red mud slurry and the pretreated red mud liquor obtained after the treatment to a replacement tank below, adding lime milk to the replacement tank, conducting stirring and natural sedimentation, conducting soilization on subnatant thick red mud slurry, and refluxing the supernatant to a red mud aeration tank.

    Ultralimit alloy and preparation method therefor

    公开(公告)号:US11530485B2

    公开(公告)日:2022-12-20

    申请号:US17419250

    申请日:2019-11-12

    Abstract: The present disclosure belongs to the field of preparation technology and provides an ultralimit alloy and a preparation method therefor. The ultralimit alloy comprises an alloy matrix. A bonding layer and a ceramic layer are successively deposited on a surface of the alloy matrix. The alloy matrix includes one of a magnesium alloy matrix, an aluminium alloy matrix, a titanium alloy matrix, an iron alloy matrix, a nickel alloy matrix, a copper alloy matrix, a zirconium alloy, and a tin alloy. For an ultralimit magnesium alloy, an ultralimit aluminium alloy, an ultralimit nickel alloy, an ultralimit titanium alloy, an ultralimit iron alloy and an ultralimit copper alloy, the bonding layer is a composite bonding layer, the ceramic layer is a composite ceramic layer, and the outside of the composite ceramic layer is further successively deposited with a reflecting layer, a catadioptric layer, an insulating layer and a carbon foam layer.

    Sesquiterpene derivative and use of the same in preparation of medicament for treating hepatitis b diseases

    公开(公告)号:US11248002B2

    公开(公告)日:2022-02-15

    申请号:US16976463

    申请日:2019-02-26

    Abstract: Disclosed are a sesquiterpene derivative and a use of the same in preparation of a medicament for treating hepatitis B diseases. The sesquiterpene derivative has the effects of down-regulating the hepatocyte nuclear factor 4α (HNF-4α) and significantly inhibiting the hepatitis B virus, and can be used for preventing and/or treating and/or assisting in the treatment of liver system diseases and symptoms caused by the hepatitis B virus, and can be used as a hepatic protective agent. In addition, the synthetic sesquiterpene derivative can also be used for preventing or treating viral infectious diseases and conditions resulting from the influenza virus, coxsackievirus, herpes simplex virus, etc. Also involved is the preparation of the synthetic sesquiterpene derivative, which acts as a raw material, in clinically acceptable pharmaceutical formulations, such as oral dosage forms such as tablets, capsules and drop pills or non-oral dosage forms such as inhalants and injections.

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