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公开(公告)号：US11680268B2
公开(公告)日：2023-06-20
申请号：US15524672
申请日：2015-11-09
CPC分类号： C12N15/64 , C12N9/1241 , C12N15/102 , C12N2310/122 , C12N2310/20
摘要： This application provides improved methods of editing the genome of a target cell. Cas9 molecules can be used to create a break in a genomic region of interest. To increase the likelihood that the break is repaired by homology-directed repair (HDR), the cell can be contacted with an HDR-enhancer. The cell may be, e.g., a human cell, a non-human animal cell, a bacterial cell, or a plant cell.
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82.发明授权公开(公告)号：US11597924B2
公开(公告)日：2023-03-07
申请号：US16088159
申请日：2017-03-24
摘要： The application provides improved methods of genome editing. The genome editing systems described herein comprise a RNA-guided nuclease molecule and a Repair-Modulating Enzyme Molecule (RMEM).
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83.发明申请公开(公告)号：US20230025279A1
公开(公告)日：2023-01-26
申请号：US17688782
申请日：2022-03-07
发明人： Morgan Lee MAEDER , David A. BUMCROT , Shen SHEN
IPC分类号： C12N15/10 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/86
摘要： CRISPR/CAS-related compositions and methods for treatment of Leber's Congenital Amaurosis 10 (LCA10) are disclosed.
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公开(公告)号：US20220273818A1
公开(公告)日：2022-09-01
申请号：US17450544
申请日：2021-10-11
摘要： Compositions and methods for treatment of CEP290 related diseases are disclosed.
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公开(公告)号：US11236313B2
公开(公告)日：2022-02-01
申请号：US16093336
申请日：2017-04-12
摘要： Disclosed herein are enzymatically active Cas9 (eaCas9) fusion molecules, comprising an eaCas9 molecule linked, e.g., covalently or non-covalently, to a template nucleic acid; gene editing systems comprising the eaCas9 fusion molecules, and methods of use thereof.
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公开(公告)号：US20210380987A1
公开(公告)日：2021-12-09
申请号：US17246081
申请日：2021-04-30
IPC分类号： C12N15/113 , C12N9/22
摘要： CRISPR/CAS-related compositions and methods for treatment of Cystic Fibrosis (CF).
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公开(公告)号：US11180793B2
公开(公告)日：2021-11-23
申请号：US15569053
申请日：2016-04-25
IPC分类号： C12Q1/6811 , C12N9/22 , G01N33/68 , C12N15/11 , C12N15/90
摘要： Disclosed herein are methods for evaluation, selection, optimization, and design of Cas9 molecule/gRNA molecule complexes.
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公开(公告)号：US11141493B2
公开(公告)日：2021-10-12
申请号：US16053763
申请日：2018-08-02
摘要： Compositions and methods for treatment of CEP290 related diseases are disclosed.
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公开(公告)号：US20210269799A1
公开(公告)日：2021-09-02
申请号：US17255140
申请日：2019-06-28
发明人： Sam Saccomano , Stacy Capehart , Bruce Eaton , Karin Zemski Berry
IPC分类号： C12N15/113 , C12N15/11
摘要： Chemical syntheses of guide molecules are disclosed, along with compositions and methods relating thereto. A cost-effective and straightforward chemical synthesis of high-purity unimolecular guide molecules with minimal n−1 and/or n+1 species, truncation species, and other contaminants by providing, among other things, methods for synthesizing unimolecular guide molecules that involve cross-linking two or more pre-annealed guide fragments.
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90.发明授权公开(公告)号：US11028411B2
公开(公告)日：2021-06-08
申请号：US16666982
申请日：2019-10-29
摘要： Engineered nucleic acids encoding genome editing system components are provided, as are engineered RNA-guided nucleases that include inserts encoded in part by cellular genomic or other sequences recognized by guide RNAs.
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