公开(公告)号：US12077802B2

公开(公告)日：2024-09-03

申请号：US16644484

申请日：2018-09-05

Applicant: INMED PHARMACEUTICALS INC.

Inventor： Sonal R. Ayakar ,  Sandip V. Pawar ,  Steven J. Hallam ,  Sazzad Hossain ,  Vikramaditya G. Yadav ,  Protiva R. Roy ,  Sarvesh K. Srivastava

IPC: C12P7/42 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N15/70 ,  C12P5/00

CPC classification number: C12P7/42 ,  C12N9/0004 ,  C12N9/1007 ,  C12N9/1241 ,  C12N9/88 ,  C12N15/70 ,  C12P5/007 ,  C12Y121/03007 ,  C12Y201/01255 ,  C12Y207/0706 ,  C12Y402/03027 ,  C12N2800/101

Abstract: Provided herein are methods and compositions for producing terpenoids in a host cell. In some cases, the terpenoids are cannabinoids.

公开(公告)号：US20240263153A1

公开(公告)日：2024-08-08

申请号：US18563127

申请日：2022-05-25

Applicant: Flagship Pioneering Innovations Vi, LLC

Inventor： Jacob Rosenblum Rubens ,  Robert James Citorik ,  Yanfang Fu ,  Cecilia Giovanna Silvia Cotta-Ramusino ,  Zi Jun Wang ,  William Edward Salomon

IPC: C12N9/12 ,  C12N15/11 ,  C12N15/90

CPC classification number: C12N9/1241 ,  C12N15/11 ,  C12N15/907

Abstract: Methods and compositions for modulating a target genome are disclosed. For instance, the disclosure provides site-specific recombinases (e.g., serine recombinases, e.g., serine integrases) capable of directing insertion of an insert DNA, or portion thereof, into a desired site in a target genome.

公开(公告)号：US12054754B2

公开(公告)日：2024-08-06

申请号：US16761206

申请日：2018-11-02

Applicant: Arbor Biotechnologies, Inc.

Inventor： David A. Scott ,  David R. Cheng ,  Winston X. Yan

IPC: C12N9/22 ,  C12N9/12 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/63 ,  C12N15/70 ,  C12N15/85

CPC classification number: C12N9/22 ,  C12N9/1241 ,  C12N15/102 ,  C12N15/1058 ,  C12N15/11 ,  C12N15/113 ,  C12N15/63 ,  C12N15/70 ,  C12N15/85 ,  C12N2310/20 ,  C12N2800/80

Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of DNA, RNA, and protein substrates. Each system includes one or more protein components and one or more nucleic acid components that together target DNA, RNA, or protein substrates.

公开(公告)号：US20240226327A9

公开(公告)日：2024-07-11

申请号：US18469512

申请日：2023-09-18

Applicant: Mammoth Biosciences, Inc.

Inventor： Timothy Robert ABBOTT ,  Aaron DELOUGHERY ,  David PAEZ-ESPINO ,  Benjamin Julius RAUCH

IPC: A61K48/00 ,  C12N9/12 ,  C12N15/11

CPC classification number: A61K48/005 ,  C12N9/1241 ,  C12N15/11

Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.

公开(公告)号：US12024726B2

公开(公告)日：2024-07-02

申请号：US17943127

申请日：2022-09-12

Applicant: Louisiana Tech Research Corporation

Inventor： Yuri Voziyanov

IPC: C12N9/12 ,  C12N15/90

CPC classification number: C12N9/1241 ,  C12N15/907 ,  C07K2319/09 ,  C07K2319/80

Abstract: The present invention provides chimeric Flp-TAL recombinases, as well as nucleic acids, and methods for the use of the chimeric Flp-TAL recombinases for site-specific alteration of a target sequence in cells.

公开(公告)号：US12018307B2

公开(公告)日：2024-06-25

申请号：US17822733

申请日：2022-08-26

Applicant: Jixun Zhan

Inventor： Jixun Zhan

IPC: C12P19/60 ,  A61K31/05 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N15/62 ,  C12N15/63

CPC classification number: C12P19/60 ,  A61K31/05 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/1241 ,  C12N15/62 ,  C12N15/63 ,  C12Y101/01022 ,  C12Y204/01017 ,  C12Y207/07009

Abstract: The present invention relates to an in vitro or in vivo process for producing a glucuronide comprising a glucuronic acid moiety bound to a phenolic hydroxyl group or a phenolic carboxyl group. Also provided are expression vectors, nucleic acids, polypeptides, and recombinant microbial cells useful in carrying out the process and prodrugs produced by the process.

公开(公告)号：US20240191270A1

公开(公告)日：2024-06-13

申请号：US18555611

申请日：2022-04-15

Applicant: INBIOSE N.V.

Inventor： Joeri Beauprez ,  Pieter Coussement ,  Thomas Decoene

IPC: C12P19/12 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P19/26

CPC classification number: C12P19/12 ,  C12N9/0006 ,  C12N9/1025 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/1241 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/52 ,  C12P19/26 ,  C12Y101/01271 ,  C12Y203/03009 ,  C12Y204/01038 ,  C12Y204/01069 ,  C12Y204/01152 ,  C12Y207/01006 ,  C12Y207/01052 ,  C12Y207/07023 ,  C12Y207/0703 ,  C12Y207/07043 ,  C12Y401/03001 ,  C12Y402/01047 ,  C12Y504/02008 ,  C12Y504/0201 ,  C12Y602/01001

Abstract: The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of metabolically engineered cells and use of said cell in a cultivation, preferably a fermentation. The present invention describes a cell for the production of a compound. The cell comprises a pathway for the production of the compound, which can be a disaccharide, oligosaccharide and/or a Neu(n)Ac-containing bioproduct, wherein (n) is 4, 5, 7, 8 or 9 or a combination thereof. The cell is metabolically engineered for enhanced synthesis of acetyl-Coenzyme A. The invention also resides in a method of producing such compound by cultivation, preferably a fermentation, with such a cell.

公开(公告)号：US20240150734A1

公开(公告)日：2024-05-09

申请号：US18051109

申请日：2022-10-31

Applicant: Poseida Therapeutics, Inc.

Inventor： Eric M. OSTERTAG ,  Blair MADISON

IPC: C12N9/12 ,  A01K67/0275 ,  A61D19/04 ,  A61K48/00 ,  C12N9/22 ,  C12N15/85

CPC classification number: C12N9/1241 ,  A01K67/0275 ,  A61D19/04 ,  A61K48/0008 ,  C12N9/22 ,  C12N15/8509 ,  C12Y207/07 ,  A01K67/0333

Abstract: The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.

公开(公告)号：US20240132927A1

公开(公告)日：2024-04-25

申请号：US18038695

申请日：2021-12-01

Applicant: ZYMtronix Catalytic Systems, Inc.

Inventor： Stephane Cedric Corgie ,  Alexander Chris Hoepker

IPC: C12P19/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N11/14

CPC classification number: C12P19/04 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1229 ,  C12N9/1241 ,  C12N9/16 ,  C12N11/14 ,  C12Y204/01069 ,  C12Y204/99006 ,  C12Y207/01052 ,  C12Y207/04006 ,  C12Y207/04014 ,  C12Y207/07043 ,  C12Y305/01052 ,  C12Y306/01001

Abstract: The invention provides modular cell-free de-novo synthesis of glycans with immobilized bionanocatalysts. The invention provides materials, and in particular, magnetic materials, for producing glycans of defined length and sequences using one or more enzymes that are immobilized within bionanocatalysts (BNCs) which in turn are embedded within scaffolds to control the synthesis in batch or continuous processes manufacturing. In some embodiments, the scaffolds are high magnetism and high porosity composite blends of thermoplastics or thermosets comprising magnetic particles that form powders. In some embodiments, Selective Laser Sintering (SLS) is used to design and produce objects via 3D printing by sintering composite magnetic powders. The modular flow cells may be mixed and matched for a highly customizable and highly efficient cell-free manufacturing process. In some embodiments the elementary and system modules provided by the invention are employed. In preferred embodiments, human milk oligosaccharides (HMOs) are produced.

公开(公告)号：US20240093254A1

公开(公告)日：2024-03-21

申请号：US18286832

申请日：2022-10-31

Applicant: Advanced Protein Technologies Corp. ,  SEOUL NATIONAL UNIVERSITY R&DB FORNDATION

Inventor： Chul Soo SHIN ,  Jong Won YOON ,  Young Ha SONG ,  Young Sun YOO ,  Jeong Su BANG ,  Heon Hak LEE

IPC: C12P19/12 ,  C12N9/10 ,  C12N9/12 ,  C12N15/72 ,  C12N15/77

CPC classification number: C12P19/12 ,  C12N9/1051 ,  C12N9/1241 ,  C12N15/72 ,  C12N15/77 ,  C12Y204/01069 ,  C12Y207/07013 ,  C12N2800/101

Abstract: The present invention relates to a method for increasing the productivity of 2′-fucosyllactose through various changes in culture medium composition and culturing on the basis of lactose, which is a substrate, wherein 2-fucosyllactose can be continuously produced in a high-yield at an optimum lactose concentration discovered by a culturing method of the present invention.