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    Ultrasound contrast agents and process for the preparation thereof
    81.
    发明申请
    Ultrasound contrast agents and process for the preparation thereof 有权
    超声造影剂及其制备方法

    公开(公告)号：US20060051297A1

    公开(公告)日：2006-03-09

    申请号：US10544123

    申请日：2004-02-03

    申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Christian Guillot

    发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Christian Guillot

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223

    摘要： Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.

    摘要翻译： 制备冻干基质的方法，并且在重构相应的可注射造影剂时，其包含主要由磷脂稳定的充气微泡的液体水性悬浮液。 该方法包括从水性介质，磷脂和与水不混溶的有机溶剂中制备乳液。 然后将乳液冷冻干燥，随后在气体填充的微泡的水性悬浮液中重构。 该方法允许获得包含具有相对小直径和窄尺寸分布的微泡的悬浮液。

    Microcapsules, method of making and their use
    83.
    发明授权
    Microcapsules, method of making and their use 失效
    微胶囊，制作方法及其用途

    公开(公告)号：US06403057B1

    公开(公告)日：2002-06-11

    申请号：US09599576

    申请日：2000-06-23

    申请人： Michel Schneider ,  Philippe Bussat

    发明人： Michel Schneider ,  Philippe Bussat

    IPC分类号： A61K4900

    CPC分类号： A61K9/0065 ,  A61K9/5015 ,  A61K49/223

    摘要： The invention relates to microcapsules to a microcapsule with a mean size from a fraction of micrometer to 1000 micrometers having a biodegradable membrane encapsulating a gas core. The membrane comprising one or more biodegradable water insoluble lipids or mixtures thereof and optionally mixtures of the lipids with up to 75% by weight of biodegradable polymers encapsulates the core which is filled with air or a gas. Microcapsules disclosed, may be non-coalescent, dry and instantly dispersible, when in suspension in a physiologically acceptable carrier are useful as delivery vehicles for therapeutically active agents and/or as contrast agents for echographic imaging of organs of human or animal body. The microcapsules of the invention are made by a method in which a water-in-oil emulsion is made from an organic solution comprising dissolved a mono-, di-, triglyceride preferably tripalmitin or tristearin and optionally therapeutically active substance and an aqueous solution containing a surfactant, optionally evaporating part of the solvent, adding a redispersing agent and freeze drying the mixture. The freeze dried mixture is then redispersed in an aqueous carrier to separate microcapsules from debris and the semi-spherical or spherical microcapsules are dried.

    摘要翻译： 本发明涉及到微胶囊的微胶囊，其平均尺寸为千分之一至1000微米，具有封装气芯的可生物降解的膜。 所述膜包含一种或多种可生物降解的水不溶性脂质或其混合物，以及脂质与高达75％（重量）可生物降解聚合物的任选混合物包封填充有空气或气体的核心。 公开的微胶囊可以是非聚结剂，干燥和即时可分散的，当在生理学上可接受的载体中的悬浮液可用作治疗活性剂的递送载体和/或作为用于人或动物体器官的回波成像的对比剂时。 本发明的微胶囊通过一种方法制备，其中油包水乳液由有机溶液制成，该有机溶液包含溶解的甘油单酯，二甘油三酯，优选三棕榈素或三硬脂精和任选的治疗活性物质和含有 表面活性剂，任选地蒸发部分溶剂，加入再分散剂并冷冻干燥混合物。 然后将冷冻干燥的混合物再分散在水性载体中以将微胶囊与碎片分离，并将半球形或球形微胶囊干燥。

    Stable microbubble suspensions as enhancement agents for ultrasonic echography
    84.
    发明授权
    Stable microbubble suspensions as enhancement agents for ultrasonic echography 有权
    稳定的微泡悬浮液作为超声波回波成像的增强剂

    公开(公告)号：US06187288B1

    公开(公告)日：2001-02-13

    申请号：US09151651

    申请日：1998-09-11

    申请人： Michel Schneider ,  Jean Brochot ,  Jérôme Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jérôme Puginier ,  Feng Yan

    IPC分类号： A61B813

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography
    87.
    发明授权
    Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography 失效
    稳定的微泡悬浮液，包括用于超声回波的饱和磷脂

    公开(公告)号：US5686060A

    公开(公告)日：1997-11-11

    申请号：US420677

    申请日：1995-04-12

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Stable microbubble suspensions as enhancement agents for ultrasound echography
    90.
    发明授权
    Stable microbubble suspensions as enhancement agents for ultrasound echography 失效
    稳定的微泡悬浮液作为超声波回波成像的增强剂

    公开(公告)号：US5597549A

    公开(公告)日：1997-01-28

    申请号：US414718

    申请日：1995-03-31

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。