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98 条记录 (耗时 0.067 秒)

    Method for wind noise reduction
    83.
    发明授权
    Method for wind noise reduction 失效
    减少风噪声的方法

    公开(公告)号：US08433564B2

    公开(公告)日：2013-04-30

    申请号：US12795188

    申请日：2010-06-07

    申请人： Alon Konchitsky ,  Alberto D Berstein ,  Sandeep Kulakcherla ,  William Martin Ribble ,  Kevin Fitzgerald ,  Don Seferovich

    发明人： Alon Konchitsky ,  Alberto D Berstein ,  Sandeep Kulakcherla ,  William Martin Ribble ,  Kevin Fitzgerald ,  Don Seferovich

    IPC分类号： G10L19/00 ,  G10L19/14 ,  G10L21/02

    CPC分类号： G10L21/0208

    摘要： A noisy signal is picked up by a microphone, digitized by an Analog to Digital Converter and fed to a processor for analysis and wind noise reduction. Most of noise reduction methods are based on the assumption that the interfering noise is stationary or slowly varying compared with speech. This assumption allows “learning” the characteristics of the noise between speech pauses and, based on a noise estimate, to build different filters that reduce the noise. In the case of wind noise this basic assumption is not valid. Wind noise is highly non-stationary, its power and spectral characteristics vary greatly. Because wind noise is not stationary, regular noise reduction methods cannot be used to reduce wind noise. For reducing wind noise effects in a device, the presence of wind should be detected reliably and then a novel approach presented here must be applied to eliminate the wind noise.

    摘要翻译： 噪声信号由麦克风拾取，由模数转换器数字化，并馈送到处理器进行分析和减少风噪声。 大多数降噪方法是基于干扰噪声与语音相比是静止的或缓慢变化的假设。 该假设允许“学习”语音暂停之间的噪声的特性，并且基于噪声估计来建立减少噪声的不同滤波器。 在风噪声的情况下，这个基本假设是无效的。 风噪声非常不稳定，其功率和光谱特性差异很大。 由于风噪声不稳定，因此不能采用常规的降噪方法来减少风噪声。 为了减少设备中的风噪声影响，应该可靠地检测风的存在，然后必须采用这里提出的新颖方法来消除风噪声。

    DSRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTIONS
    87.
    发明申请
    DSRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTIONS 审中-公开
    DSRNA组合物和治疗HPV感染的方法

    公开(公告)号：US20100249052A1

    公开(公告)日：2010-09-30

    申请号：US12593202

    申请日：2008-03-25

    申请人： John Benson ,  Kevin Fitzgerald ,  Birgit Bramlage ,  Pamela Tan ,  Hans-Peter Vornlocher

    发明人： John Benson ,  Kevin Fitzgerald ,  Birgit Bramlage ,  Pamela Tan ,  Hans-Peter Vornlocher

    IPC分类号： C12N15/86 ,  C07H21/02 ,  A61K31/7088

    CPC分类号： C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12Y603/02019 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.

    摘要翻译： 本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且其与至少一部分选自人E6AP基因的HPV靶基因互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。

    dsRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTION
    90.
    发明申请
    dsRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTION 有权
    dsRNA组合物和治疗HPV感染的方法

    公开(公告)号：US20090247607A1

    公开(公告)日：2009-10-01

    申请号：US12294388

    申请日：2007-03-23

    申请人： John Benson ,  Birgit Bramlage ,  Kevin Fitzgerald ,  Pamela Tan ,  Hans-Peter Vornlocher

    发明人： John Benson ,  Birgit Bramlage ,  Kevin Fitzgerald ,  Pamela Tan ,  Hans-Peter Vornlocher

    IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N5/10 ,  C12N15/74 ,  A61P31/12

    CPC分类号： C12N15/1137 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2320/31 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.

    摘要翻译： 本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且与选自HPV E1，HPV E6中的HPV靶基因的至少一部分基本互补 和人类E6AP基因。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。