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    Concomitant administration of glucocorticoid receptor modulators and CYP3A inhibitors
    2.
    发明授权
    Concomitant administration of glucocorticoid receptor modulators and CYP3A inhibitors 有权

    公开(公告)号：US12097210B2

    公开(公告)日：2024-09-24

    申请号：US18241364

    申请日：2023-09-01

    申请人： Corcept Therapeutics, Inc.

    发明人： Joseph K. Belanoff

    IPC分类号： A61K31/575 ,  A61K9/00 ,  A61K31/496 ,  A61K31/7048 ,  A61K45/06 ,  A61P3/10

    CPC分类号： A61K31/575 ,  A61K9/0056 ,  A61K31/496 ,  A61K31/7048 ,  A61K45/06 ,  A61P3/10 ,  A61K31/567 ,  A61K2300/00 ,  A61K31/496 ,  A61K2300/00

    摘要： Applicant provides methods of treating diseases including Cushing's syndrome and hormone-sensitive cancers by concomitant administration of a glucocorticoid receptor modulator (GRM) and steroidogenesis inhibitors, and by concomitant administration of a GRM and CYP3A inhibitors. The GRM may be, e.g., mifepristone; the CYP3A inhibitors or steroidogenesis inhibitors (collectively “inhibitors”) may be, e.g., ketoconazole or itraconazole. Inhibitors may cause toxicity or other serious adverse reactions; concomitant administration of inhibitors with other drugs may increase the risk of such toxicity and adverse reactions due to the inhibitors and/or the other drugs. Applicant has surprisingly found that GRMs may be administered to subjects receiving inhibitors without increasing the risk of adverse reactions; for example, Applicant has found that mifepristone may be concomitantly administered with ketoconazole or itraconazole, providing safe concomitant administration of the GRM and ketoconazole or itraconazole. In embodiments, the GRM dose may be reduced during concomitant administration of the GRM with inhibitors.

    METHOD FOR DIFFERENTIALLY DIAGNOSING ACTH-DEPENDENT CUSHING'S SYNDROME
    10.
    发明公开
    METHOD FOR DIFFERENTIALLY DIAGNOSING ACTH-DEPENDENT CUSHING'S SYNDROME 审中-公开

    公开(公告)号：US20230324415A1

    公开(公告)日：2023-10-12

    申请号：US18208025

    申请日：2023-06-09

    申请人： Corcept Therapeutics, Inc.

    发明人： Andreas G. Moraitis

    IPC分类号： G01N33/74 ,  A61K31/573 ,  A61K31/567 ,  A61K31/4745

    CPC分类号： G01N33/74 ,  A61K31/573 ,  A61K31/567 ,  A61K31/4745 ,  G01N2800/048 ,  G01N2333/695

    摘要： Applicant discloses herein methods for differentially diagnosing adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome in a patient where the differential diagnosis is between ectopic ACTH syndrome and Cushing Disease. The methods include administration of an amount of a glucocorticoid receptor antagonist (GRA) effective to increase ACTH in patients with ectopic ACTH syndrome but not in those with Cushing's Disease. Method steps may include administering a GRA dose sufficient to increase ACTH from the pituitary gland by at least two fold in persons with normal HPA function (e.g., 300 to 1500 milligrams); waiting for at least two hours; and obtaining from the patient an ACTH concentration ratio derived from the ACTH concentrations in blood samples obtained from an inferior petrosal venous sinus and from a peripheral vein. The patient is diagnosed with Cushing Disease if the ACTH concentration ratio is greater than 3.