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94 条记录 (耗时 0.044 秒)

    Ophthalmic compositions comprising trefoil factor family peptides
    84.
    发明授权
    Ophthalmic compositions comprising trefoil factor family peptides 有权
    包含三叶因子家族肽的眼科组合物

    公开(公告)号：US06984628B2

    公开(公告)日：2006-01-10

    申请号：US10621053

    申请日：2003-07-15

    申请人： Peter G. Bakhit ,  Orest Olejnik ,  Richard Graham

    发明人： Peter G. Bakhit ,  Orest Olejnik ,  Richard Graham

    IPC分类号： A61K38/02 ,  A61K38/17

    CPC分类号： A61K36/47 ,  A61K31/715 ,  A61K35/30 ,  A61K36/48 ,  A61K38/13 ,  A61K38/1841 ,  A61K38/22 ,  A61K2300/00

    摘要： This invention relates to compositions comprising trefoil family factor peptides which are useful in preventing or treating dry eye by topical administration of the composition to eye of the patient. One aspect of this invention relates to topical ophthalmic compositions comprising a trefoil factor family peptide, and preferably, a mucoadhesive component, as described herein. Another aspect of this invention relates to the use of these compositions to treat or prevent dry eye in a patient.

    摘要翻译： 本发明涉及包含三叶片家族因子肽的组合物，其可用于通过将组合物局部施用于患者眼睛来预防或治疗干眼症。 本发明的一个方面涉及如本文所述的包含三叶因子家族肽，优选粘膜粘附成分的局部眼用组合物。 本发明的另一方面涉及这些组合物在患者体内治疗或预防干眼症的用途。

    Compositions and methods comprising memantine and polyanionic polymers
    85.
    发明申请
    Compositions and methods comprising memantine and polyanionic polymers 审中-公开
    包括美金刚和聚阴离子聚合物的组合物和方法

    公开(公告)号：US20050031652A1

    公开(公告)日：2005-02-10

    申请号：US10941272

    申请日：2004-09-14

    申请人： Patrick Hughes ,  Orest Olejnik ,  Rhett Schiffman

    发明人： Patrick Hughes ,  Orest Olejnik ,  Rhett Schiffman

    IPC分类号： A61K9/00 ,  A61K31/13 ,  A61K47/38

    CPC分类号： A61K31/13

    摘要： Compositions are provided including a neuroprotective amine related to adamantane and a polyanionic polymer which are well tolerated, non-toxic and/or result in reduced or fewer side effects. Methods are provided employing such compositions, for example, topically administering such compositions to human or animal eyes, for treating human or animal eyes.

    摘要翻译： 提供的组合物包括与金刚烷和聚阴离子聚合物相关的神经保护胺，其耐受性良好，无毒性和/或导致副作用降低或减少。 提供使用这样的组合物的方法，例如将这些组合物局部施用于人或动物眼睛，用于治疗人或动物眼睛。

    Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
    88.
    发明申请
    Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug 审中-公开
    将活性药物通过前药的结膜下或眼周递送递送至眼后部

    公开(公告)号：US20050009910A1

    公开(公告)日：2005-01-13

    申请号：US10617468

    申请日：2003-07-10

    申请人： Patrick Hughes ,  Orest Olejnik

    发明人： Patrick Hughes ,  Orest Olejnik

    IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/203 ,  A61K31/557

    CPC分类号： A61K31/557 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/203

    摘要： The present invention relates to method of sustained-delivery of an active drug to a posterior part of an eye of a mammal to treat or prevent a disease or condition affecting said mammal, wherein said disease or condition can be treated or prevented by the action of said active drug upon said posterior part of the eye, comprising administering an effective amount of an ester prodrug of the active drug subconjunctivally or periocularly. Preferably, the active drug is more than about 10 times as active as the prodrug. Other aspects of this invention deal with the treatment of certain diseases by the periocular or subconjunctival delivery of an ester prodrug, and certain pharmaceutical products containing ester prodrugs for periocular or subconjunctival administration.

    摘要翻译： 本发明涉及将活性药物持续递送至哺乳动物眼睛的后部以治疗或预防影响所述哺乳动物的疾病或病症的方法，其中所述疾病或病症可以通过以下作用来治疗或预防： 所述活性药物在眼睛的所述后部，包括给予有效量的活性药物的结膜下或眼下的酯前药。 优选地，活性药物的活性大于前药的约10倍。 本发明的其它方面涉及通过酯前药的眼周或结膜下递送治疗某些疾病，以及含有用于眼周或结膜下给药的酯前药的某些药物产品。

    Ophthalmic compositions containing loratadine
    89.
    发明授权
    Ophthalmic compositions containing loratadine 有权
    含有氯雷他定的眼用组合物

    公开(公告)号：US06635654B1

    公开(公告)日：2003-10-21

    申请号：US10340355

    申请日：2003-01-09

    申请人： Chin-Ming Chang ,  Eldon Q. Farnes ,  Orest Olejnik ,  James N. Chang

    发明人： Chin-Ming Chang ,  Eldon Q. Farnes ,  Orest Olejnik ,  James N. Chang

    IPC分类号： A61K3144

    CPC分类号： A61K9/0048 ,  A61K31/4545

    摘要： The present invention is directed to an ophthalmic formulation which comprises a therapeutically effective amount of ethyl 4-(8-chloro-5,6-dihydro-11-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate, known as loratadine, a fatty acid ester, and a surfactant, which has been found to be useful in treating ocular allergies, especially allergic conjunctivitis, and related conditions.

    摘要翻译： 本发明涉及一种眼用制剂，其包含治疗有效量的4-（8-氯-5,6-二氢-11-苯并[5,6]环庚并[1,2-b]吡啶-11- 已经被发现可用于治疗眼部过敏症，特别是过敏性结膜炎和相关病症的已知的氯雷他定，脂肪酸酯和表面活性剂的亚胺基-1-哌啶羧酸酯。