公开(公告)号：US5063305A

公开(公告)日：1991-11-05

申请号：US338896

申请日：1989-04-14

申请人： Hiroshi Minami ,  Koreaki Fujita

发明人： Hiroshi Minami ,  Koreaki Fujita

IPC分类号： H03F3/45 ,  H03K3/3565

CPC分类号： H03K3/3565 ,  H03F3/45076 ,  H03F3/45179 ,  H03F2203/45364 ,  H03F2203/45394 ,  H03F2203/45674 ,  H03F2203/45712

摘要： In a MOS transistor circuit (comprising a pair of current mirror circuits, each comprising: first and second MOS transistors having their gate electrodes connected together third and fourth MOS transistors respectively connected in series with the first and second transistors, the third and the fourth MOS transistors of the pair of current mirror circuits receiving a pair of complementary signals at their gate electrodes; and the nodes between the second and the fourth MOS transistors forming output nodes of the current mirror circuits), a pair of capacitors each coupling the output of one current mirror circuit to the gate electrodes of the first and the second MOS transistors of the other current mirror circuit. This provides positive feedback. The change in the outputs responsive to change in the inputs is thereby accelerated.

公开(公告)号：US4907201A

公开(公告)日：1990-03-06

申请号：US218888

申请日：1988-07-14

申请人： Hiroshi Minami ,  Koreaki Fujita

发明人： Hiroshi Minami ,  Koreaki Fujita

IPC分类号： H03F3/45 ,  H03K3/3565

CPC分类号： H03K3/3565 ,  H03F3/45076 ,  H03F3/45179 ,  H03F2203/45364 ,  H03F2203/45394 ,  H03F2203/45674 ,  H03F2203/45712

摘要： In a MOS transistor circuit (comprising a pair of current mirror circuits, each comprising: first and second MOS transistors having their gate electrodes connected together third and fourth MOS transistors respectively connected in series with the first and second transistors, the third and the fourth MOS transistors of the pair of current mirror circuits receiving a pair of complementary signals at their gate electrodes; and the nodes between the second and the fourth MOS transistors forming output nodes of the current mirror circuit), a pair of capacitors each coupling the output of one current mirror circuit to the gate electrodes of the first and the second MOS transistors of the other current mirror circuit. This provides positive feedback. The change in the outputs responsive to change in the inputs is thereby accelerated.

摘要翻译： 在MOS晶体管电路（包括一对电流镜电路）中，每一个包括：第一和第二MOS晶体管，其栅电极连接在一起分别与第一和第二晶体管串联的第三和第四MOS晶体管，第三和第四MOS 一对电流镜电路的晶体管在其栅电极处接收一对互补信号;以及第二和第四MOS晶体管之间的节点，形成电流镜电路的输出节点），一对电容器，每个电容器将一个 电流镜电路连接到另一电流镜电路的第一和第二MOS晶体管的栅电极。 这提供了积极的反馈。 因此，响应于输入变化的输出的变化被加速。

公开(公告)号：US3935266A

公开(公告)日：1976-01-27

申请号：US192557

申请日：1971-10-26

申请人： Sadao Hashimoto ,  Ryuji Sakakibara ,  Yasushi Kurashige ,  Katsuo Takikawa ,  Yoko Osame ,  Hiroshi Minami ,  Takashi Suzue

发明人： Sadao Hashimoto ,  Ryuji Sakakibara ,  Yasushi Kurashige ,  Katsuo Takikawa ,  Yoko Osame ,  Hiroshi Minami ,  Takashi Suzue

IPC分类号： A61K31/16 ,  A61K31/165 ,  C07C67/00 ,  C07C239/00 ,  C07C279/14 ,  C07C103/30

CPC分类号： C07C279/14

摘要： An N-substituted guanidino acid derivatives having the following formula of ##EQU1## wherein R is an alkyl having 6 to 15 carbon atoms,. a cycloalkyl having 6 to 15 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.9); A represents R.sup.1 or R.sub.2 CO--, R.sup.1 being an alkyl having 1 to 4 carbon atoms, an alkenyl having 2 to 4 carbon atoms, cyclohexyl, a phenyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, or a benzyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, and R.sup.2 being an alkyl of 1 to 3 carbon atoms, an alkenyl of 2 to 3 carbon atoms, an aryl of 6 to 8 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.2); and n is an integer of 4 to 10. The present compounds are excellent in pharmacological activities, particularly in antagonism to bradykinin and histamine, and useful as anti-inflammatory agent.

摘要翻译： 具有下式的ANH ANGLE CNH（CH 2）n CONHR NH的N-取代胍基衍生物，其中R是具有6至15个碳原子的烷基。 具有6至15个碳原子的环烷基或芳基（C 6至C 8）烷基（C 1至C 9）; A表示R 1或R 2 CO-，R 1为具有1至4个碳原子的烷基，具有2至4个碳原子的烯基，环己基，含有或不含有低级烷基，卤代低级烷基，低级烷氧基 ，羟基或卤素，或含有或不含低级烷基，卤代低级烷基，低级烷氧基，羟基或卤素的取代基的苄基，R 2为1至3个碳原子的烷基，烯基为2 至3个碳原子，6至8个碳原子的芳基或芳基（C6至C8）烷基（C1至C2）; n为4〜10的整数。本发明化合物的药理活性特别优选缓激肽和组胺的拮抗作用，作为抗炎剂有用。