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111 条记录 (耗时 0.031 秒)

    Model rat with the onset of prostatic cancer
    81.
    发明授权
    Model rat with the onset of prostatic cancer 有权
    模型大鼠与前列腺癌的发病

    公开(公告)号：US07105717B1

    公开(公告)日：2006-09-12

    申请号：US10204504

    申请日：2000-06-13

    申请人： Tomoyuki Shirai ,  Makoto Asamoto ,  Satoru Takahashi

    发明人： Tomoyuki Shirai ,  Makoto Asamoto ,  Satoru Takahashi

    IPC分类号： A01K67/00

    CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/005 ,  C12N2710/22022

    摘要： To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the onset of prostate cancer which can develop prostate cancer including invasive cancer and can be bred for generations stably is established by: ligating an SV40 large T antigen gene onto the downstream of rat probasin gene promoter; the resulting PBSVT transgene is introduced into a fertilized egg of a Sprague-Dawley rat; after the introduction, the fertilized egg is transplanted into a recipient rat; a transgenic rat obtained from the recipient rat is then mated with a wild-type Sprague-Dawley rat; the transgenic offspring rats thus obtained are similarly can be bred for generations thereafter; and transgenic rats developing prostate cancer are selected through histopathological observation of the prostate.

    摘要翻译： 提供具有前列腺癌发病的大鼠模型，其中可以开发包括侵袭性癌症的前列腺癌并且可以稳定繁殖。 通过将SV40大T抗原基因连接到大鼠probasin基因启动子的下游，建立可以发展前列腺癌包括侵袭性癌症并可以稳定繁殖的前列腺癌的大鼠模型， 将得到的PBSVT转基因导入Sprague-Dawley大鼠的受精卵中; 引入后，将受精卵移植到受体大鼠中; 然后将从受体大鼠获得的转基因大鼠与野生型Sprague-Dawley大鼠配对; 这样获得的转基因后代大鼠同样可以繁殖后代; 并通过组织病理学观察前列腺来选择发展前列腺癌的转基因大鼠。

    Switching power supply unit and semiconductor device for switching power supply
    82.
    发明申请
    Switching power supply unit and semiconductor device for switching power supply 有权
    开关电源单元和开关电源的半导体器件

    公开(公告)号：US20060018136A1

    公开(公告)日：2006-01-26

    申请号：US11180702

    申请日：2005-07-14

    申请人： Satoru Takahashi

    发明人： Satoru Takahashi

    IPC分类号： H02M3/335

    CPC分类号： H02M3/33523 ,  H02M2001/0006

    摘要： Overload protecting operation is performed by controlling the current peak value of a switching device 1 through the use of a comparator 8, a NAND circuit 5, and so on according to variations in feedback current being input to a feedback signal control circuit 11, internally setting the overcurrent protection of switching device 1 through the use of a clamp circuit 12, charging a capacitor 34 when having fallen below a specified current smaller than current required for the overcurrent protection for a fixed time period, and detecting rise in voltage VOL at the capacitor 34 to a constant voltage to stop switching operation. By achieving the overload protection under normal load and the overcurrent protection against peak load in a single switching power supply unit, problems such as the complexity of the unit and an increase in the element count of the control circuit are solved.

    摘要翻译： 通过使用比较器8，NAND电路5等来根据输入到反馈信号控制电路11的反馈电流的变化来控制开关装置1的电流峰值，进行过载保护动作，内部设定 通过使用钳位电路12对开关装置1进行过电流保护，当电容器34在比固定时间段内的过电流保护小于规定电流的电流下进行充电，并且检测电容器的电压VOL的升高 34到恒定电压，停止开关动作。 通过在单个开关电源单元中实现正常负载下的过载保护和峰值负载的过流保护，解决了单元的复杂性和控制电路的元件数量增加等问题。

    Semiconductor switch having a voltage detection function
    86.
    发明授权
    Semiconductor switch having a voltage detection function 有权

    公开(公告)号：US06545515B2

    公开(公告)日：2003-04-08

    申请号：US09904125

    申请日：2001-07-12

    申请人： Satoru Takahashi ,  Seiki Yamaguchi ,  Kouji Takada

    发明人： Satoru Takahashi ,  Seiki Yamaguchi ,  Kouji Takada

    IPC分类号： H03B100

    CPC分类号： H03K17/0822

    摘要： In a semiconductor switch, a voltage detection circuit is provided so as to be in parallel with a first switching element for turning on/off a power supply to a load, in which a voltage detection portion for detecting a drain voltage of the first switching element by dividing a voltage upon a resistance ratio or the like and a second switching element are connected in series to each other. The second switching element is turned on/off in accordance with ON/OFF of the first switching element. Accordingly, detection of a drain voltage is performed normally when the first switching element is in an ON state. When the first switching element is in an OFF state, a leakage current can be reduced by the second switching element.

    Torque-limiting device for vehicle
    89.
    发明授权
    Torque-limiting device for vehicle 有权

    公开(公告)号：US10208807B2

    公开(公告)日：2019-02-19

    申请号：US15047321

    申请日：2016-02-18

    申请人： Takeshi Miyagawa ,  Satoru Takahashi

    发明人： Takeshi Miyagawa ,  Satoru Takahashi

    IPC分类号： F16D7/02 ,  F16F15/129 ,  B60K6/365 ,  B60K6/445

    摘要： Since a friction force generated on friction surfaces between a pressure plate and a first friction material is smaller than a friction force generated on friction surfaces between a lining plate and the first friction material, when a torque is input to a damper device, a slip first occurs between the pressure plate and the first friction material, and the lining plate and the first friction material integrally rotate. In this case, a hysteresis torque is generated based on the friction force between the pressure plate and the first friction material. Since a torque limiter mechanism also acts as a hysteresis mechanism in this way, a torque limiter mechanism is realized that can generate the hysteresis torque with a simple structure.

    Speed profile creation device and automatic train operation apparatus
    90.
    发明授权
    Speed profile creation device and automatic train operation apparatus 有权
    速度轮廓创建装置和自动列车运行装置

    公开(公告)号：US09205851B2

    公开(公告)日：2015-12-08

    申请号：US14350431

    申请日：2012-02-29

    申请人： Koki Yoshimoto ,  Satoru Takahashi ,  Kenji Ueda

    发明人： Koki Yoshimoto ,  Satoru Takahashi ,  Kenji Ueda

    IPC分类号： G05D1/00 ,  B61L27/00

    CPC分类号： B61L27/0027

    摘要： A speed profile creation device includes: a traveling simulator that creates, from a traveling instruction, a speed profile of allowing the train to travel through a traveling section together with a traveling time and energy consumption amount thereof by using a route condition, train performance, and a traveling condition; a traveling instruction draft creator that creates a plurality of traveling instruction drafts in which a reference speed profile is changed so that the energy consumption amount can decrease though the traveling time is lengthened a little; an optimum speed profile selector that selects an optimum speed profile in which an energy consumption amount reduction effect is maximum among the plurality of traveling instruction drafts; and a reference speed profile updating unit that updates the reference speed profile until the traveling time of the optimum speed profile becomes equivalent to the target traveling time.

    摘要翻译： 速度轮廓创建装置包括：行驶模拟器，其通过使用路线条件，列车性能，从行驶指示，创建允许列车行驶通过行驶部分的行驶时间和能量消耗量的速度轮廓， 和旅行状况; 创建多个行驶指令草案的旅行指令草案创建者，其中改变参考速度分布，使得能量消耗量可以随着行进时间的延长而减少; 选择最佳速度曲线选择器，其选择在所述多个行驶指示牵引中能量消耗量减小效应最大的最佳速度曲线; 以及参考速度轮廓更新单元，其更新基准速度轮廓，直到最佳速度轮廓的行驶时间变得等于目标行驶时间。