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    AZABICYCLOALKANE COMPOUNDS
    81.
    发明申请
    AZABICYCLOALKANE COMPOUNDS 有权
    化学结构式

    公开(公告)号：US20100197922A1

    公开(公告)日：2010-08-05

    申请号：US12756694

    申请日：2010-04-08

    Applicant: Mathai Mammen ,  Adam Hughes

    Inventor： Mathai Mammen ,  Adam Hughes

    IPC: C07D491/08

    CPC classification number: C07D451/02 ,  A61K31/46 ,  A61K31/4743 ,  C07D451/12 ,  C07D471/08

    Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

    Abstract translation: 本发明提供式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的化合物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 这些化合物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

    COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
    82.
    发明申请
    COMPOUNDS HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY 审中-公开
    具有BETA2 ADRENERGIC受体激动剂和MUSCARINIC受体拮抗剂活性的化合物

    公开(公告)号：US20090182010A1

    公开(公告)日：2009-07-16

    申请号：US12412194

    申请日：2009-03-26

    Applicant: Mathai Mammen ,  Trevor Mischkl

    Inventor： Mathai Mammen ,  Trevor Mischkl

    IPC: A61K31/4709 ,  C07D215/12 ,  A61K31/47 ,  A61P11/00

    CPC classification number: C07D213/40 ,  C07C271/28 ,  C07D215/26 ,  C07D277/28 ,  C07D333/20 ,  C07D409/12

    Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8a, R8b, W, a and bare as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Accordingly, such compounds are expected to be useful as therapeutic agents for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

    Abstract translation: 本发明提供了式I化合物或其药学上可接受的盐或溶剂合物或立体异构体：其中R1，R2，R3，R4，R5，R6，R7，R8a，R8b， 本发明的化合物具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 因此，预期这些化合物可用作治疗肺部疾病如慢性阻塞性肺疾病和哮喘的治疗剂。

    Biphenyl compounds useful as muscarinic receptor antagonists
    83.
    发明授权
    Biphenyl compounds useful as muscarinic receptor antagonists 有权
    用作毒蕈碱受体拮抗剂的联苯化合物

    公开(公告)号：US07560469B2

    公开(公告)日：2009-07-14

    申请号：US11077436

    申请日：2005-03-10

    Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

    Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu

    IPC: A61K31/45 ,  C07D211/40

    CPC classification number: C07D211/62 ,  C07D409/14

    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, Ar1, R1, R2, R3, R4, R6, R7, R8, and W are as defined in the specification. The compounds of formula I are mescaline receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

    Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，s，t，Ar1，R1，R2，R3，R4，R6，R7，R8和W如 规范。 式I化合物是麦芽糖素受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

    Biphenyl compounds useful as muscarinic receptor antagonists
    86.
    发明授权
    Biphenyl compounds useful as muscarinic receptor antagonists 有权
    用作毒蕈碱受体拮抗剂的联苯化合物

    公开(公告)号：US07456199B2

    公开(公告)日：2008-11-25

    申请号：US11077222

    申请日：2005-03-10

    Applicant: Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Trevor Mischki ,  Viengkham Malathong

    Inventor： Mathai Mammen ,  Yu-Hua Ji ,  YongQi Mu ,  Trevor Mischki ,  Viengkham Malathong

    IPC: C07D211/44 ,  A61K31/45

    CPC classification number: C07D211/46

    Abstract: This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

    Abstract translation: 本发明提供式I化合物：其中a，b，c，m，p，s，t，W，Ar 1，X 1，R 1 R 2，R 3，R 3，R 4，R 6和R 6， 7 如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

    Azabicycloalkane compounds
    87.
    发明授权
    Azabicycloalkane compounds 有权
    氮杂双环烷烃化合物

    公开(公告)号：US07358244B2

    公开(公告)日：2008-04-15

    申请号：US10854829

    申请日：2004-05-27

    Applicant: Mathai Mammen ,  Adam Hughes

    Inventor： Mathai Mammen ,  Adam Hughes

    IPC: A61K31/44 ,  A61K31/54 ,  C07D221/22 ,  C07D451/02 ,  C07D417/00

    CPC classification number: C07D451/02 ,  A61K31/46 ,  A61K31/4743 ,  C07D451/12 ,  C07D471/08

    Abstract: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

    Abstract translation: 本发明提供了式I化合物：其中R 1，R 2，R 3，R 4，R 4， 其中R 6，R 6和R 7如本说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的化合物具有β2 N 2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性。 这些化合物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

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