公开(公告)号：US4812314A

公开(公告)日：1989-03-14

申请号：US832929

申请日：1986-02-24

申请人： Yechezkel Barenholz ,  Elishalom Yechiel

发明人： Yechezkel Barenholz ,  Elishalom Yechiel

IPC分类号： A61K38/00 ,  A61K9/127 ,  A61K9/133 ,  A61K31/685 ,  A61P9/00 ,  A61P15/00 ,  A61P43/00 ,  A61K37/22 ,  B01J13/02

CPC分类号： A61K31/685 ,  A61K9/127 ,  Y10S128/03 ,  Y10S436/829 ,  Y10S514/824 ,  Y10S514/878 ,  Y10S514/879 ,  Y10T428/2984

摘要： A method of treating a relatively aged animal to reverse age-related changes in the lipid composition of organ and tissue cells, such as heart muscle cells, and the ability of the animal to withstand respiratory stress. A suspension of small unilamellar vesicles composed predominantly of egg phosphatidyl choline is administered parenterally to the animal, preferably over a period of several days and at a dose level of between about 0.1 and 1 grams lipid per kg body weight per day. Changes in the heart muscle cells are reflected in decreased levels of serum creatine phosphokinase. Liposome administration is continued until the serum creatine phosphokinase level drops at least about 50%. Also disclosed are liposome treatment methods for increasing longevity and male fertility.

摘要翻译： 治疗相对老化的动物以逆转器官和组织细胞（例如心肌细胞）的脂质组成中的年龄相关变化的方法以及动物抵抗呼吸应激的能力。 主要由卵磷脂酰胆碱组成的小单层囊泡的悬浮液经肠胃外给予动物，优选在几天的时间内，并且剂量水平为每天每kg体重约0.1至1克脂质。 心肌细胞的变化反映在血清肌酸磷酸激酶水平的降低。 持续进行脂质体给药，直到血清肌酸磷酸激酶水平下降至少约50％。 还公开了用于增加寿命和雄性生育力的脂质体治疗方法。