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115 条记录 (耗时 0.045 秒)

    CYTOKINE PROTEIN FAMILY
    85.
    发明申请
    CYTOKINE PROTEIN FAMILY 有权
    细胞因子蛋白家族

    公开(公告)号：US20070128205A1

    公开(公告)日：2007-06-07

    申请号：US11539078

    申请日：2006-10-05

    申请人： Paul Sheppard ,  Brian Fox ,  Kevin Klucher ,  David Taft ,  Wayne Kindsvogel

    发明人： Paul Sheppard ,  Brian Fox ,  Kevin Klucher ,  David Taft ,  Wayne Kindsvogel

    IPC分类号： A61K39/42

    CPC分类号： C07K14/715 ,  A61K38/20 ,  A61K38/21 ,  C07K14/56 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/76 ,  C12Q2600/158 ,  Y02A50/473

    摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class TI cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

    摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是TI类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。

    ANTIBODIES THAT BIND BOTH BCMA AND TACI
    86.
    发明申请
    ANTIBODIES THAT BIND BOTH BCMA AND TACI 审中-公开
    BCMA和TACI两端的抗体

    公开(公告)号：US20070048319A1

    公开(公告)日：2007-03-01

    申请号：US11553628

    申请日：2006-10-27

    申请人： Wayne Kindsvogel

    发明人： Wayne Kindsvogel

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/34

    摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor or an anti-receptor antibody, have proven usefulness in both basic research and as therapeutics. The present invention provides antibodies that bind two tumor necrosis factor receptor family members: the transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptor, and the B-cell maturation (BCMA) receptor.

    摘要翻译： 干扰肿瘤坏死因子受体与其配体如可溶性受体或抗受体抗体的结合的分子已被证明在基础研究和治疗中都是有用的。 本发明提供了结合两种肿瘤坏死因子受体家族成员的抗体：跨膜激活剂和钙调节剂和亲环蛋白配体相互作用（TACI）受体和B细胞成熟（BCMA）受体。

    ANTIBODIES THAT BIND BOTH BCMA AND TACI
    87.
    发明申请
    ANTIBODIES THAT BIND BOTH BCMA AND TACI 审中-公开

    公开(公告)号：US20070048221A1

    公开(公告)日：2007-03-01

    申请号：US11553637

    申请日：2006-10-27

    申请人： Wayne Kindsvogel

    发明人： Wayne Kindsvogel

    IPC分类号： A61K51/00 ,  A61K39/395

    CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/34

    摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor or an anti-receptor antibody, have proven usefulness in both basic research and as therapeutics. The present invention provides antibodies that bind two tumor necrosis factor receptor family members: the transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptor, and the B-cell maturation (BCMA) receptor.

    METHODS OF USING ANTIBODIES THAT BIND BOTH BCMA AND TACI
    89.
    发明申请
    METHODS OF USING ANTIBODIES THAT BIND BOTH BCMA AND TACI 审中-公开
    使用与BCMA和TACI结合的抗体的方法

    公开(公告)号：US20090155281A1

    公开(公告)日：2009-06-18

    申请号：US12212351

    申请日：2008-09-17

    申请人： Wayne Kindsvogel

    发明人： Wayne Kindsvogel

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/34

    摘要： Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor or an anti-receptor antibody, have proven usefulness in both basic research and as therapeutics. The present invention provides antibodies that bind two tumor necrosis factor receptor family members: the transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptor, and the B-cell maturation (BCMA) receptor.

    摘要翻译： 干扰肿瘤坏死因子受体与其配体如可溶性受体或抗受体抗体的结合的分子已被证明在基础研究和治疗中都是有用的。 本发明提供了结合两种肿瘤坏死因子受体家族成员的抗体：跨膜激活剂和钙调节剂和亲环蛋白配体相互作用（TACI）受体和B细胞成熟（BCMA）受体。