公开(公告)号：US07112405B2

公开(公告)日：2006-09-26

申请号：US10260375

申请日：2002-09-27

申请人： Eric B. Kmiec ,  Michael C. Rice ,  Li Liu

发明人： Eric B. Kmiec ,  Michael C. Rice ,  Li Liu

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12N15/102 ,  A61K38/00

摘要： Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group.

公开(公告)号：US20060148823A1

公开(公告)日：2006-07-06

申请号：US11326084

申请日：2006-01-05

申请人： Steven Coats ,  Scott Dax ,  Bart DeCorte ,  Li Liu ,  Mark McDonnell ,  James McNally

发明人： Steven Coats ,  Scott Dax ,  Bart DeCorte ,  Li Liu ,  Mark McDonnell ,  James McNally

IPC分类号： A61K31/506 ,  A61K31/497 ,  A61K31/517 ,  A61K31/4709 ,  A61K31/454 ,  C07D403/02 ,  C07D401/02

CPC分类号： C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

公开(公告)号：US20060029398A1

公开(公告)日：2006-02-09

申请号：US10913915

申请日：2004-08-06

申请人： Li Liu ,  Alexei Pilipetskii ,  William Anderson ,  Jin-Xing Cai ,  Morten Nissov

发明人： Li Liu ,  Alexei Pilipetskii ,  William Anderson ,  Jin-Xing Cai ,  Morten Nissov

IPC分类号： H04B10/04

CPC分类号： H04J14/02 ,  H04B10/506 ,  H04B10/5161 ,  H04J14/0224

摘要： A method and apparatus for transmitting optical signals of different modulation formats in distinct bands. The optical signals within each band may be separated by a predetermined channel spacing, and the distinct bands may be separated by a predetermined band separation distance. The band separation distance may be about twice the predetermined channel spacing.

摘要翻译： 一种在不同频带中发送不同调制格式的光信号的方法和装置。 每个频带内的光信号可以被预定的信道间隔分开，并且不同的频带可以被隔开预定的频带间隔距离。 频带分离距离可以是预定信道间隔的大约两倍。

公开(公告)号：US20050234117A1

公开(公告)日：2005-10-20

申请号：US11143814

申请日：2005-06-02

申请人： Ashis Saha ,  David End ,  Bart De Corte ,  Henry Breslin ,  Li Liu

发明人： Ashis Saha ,  David End ,  Bart De Corte ,  Henry Breslin ,  Li Liu

IPC分类号： A61K31/4196 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61P1/00 ,  A61P1/18 ,  A61P11/00 ,  A61P13/10 ,  A61P13/12 ,  A61P17/00 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D249/08 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D249/08 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L1 and L2 are R1—Y— wherein each (R1—Y)— substituent is defined independently of the other; Y is C1-4alkanediyl, C2-4alkenediyl, C2-4alkynediyl, C(═O), or a direct bond; R1 is hydrogen, cyano, aryl or a substituted or unsubstituted C1-14heterocycle; =Z1-Z2=Z3- represents a radical of formula ═N—N═CH— (a-1), ═N—CH═N— (a-2), ═CH—N═N— (a-3); X is SO2, (CH2)n wherein n is 1 to 4, C(═O), C(═S), or a direct bond; R2 is aryl, C3-7cycloalkyl, C3-7cycloalkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted C1-14heterocycle, C3-7cycloalkyl, hydroxycarbonyl, C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, hydroxyC1-6alkyloxy, hydroxyC1-6alkylthio and arylC1-6alkylthio, C1-12alkyl or C1-12alkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted C1-14heterocycle, C3-7cycloalkyl, hydroxycarbonyl, C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, hydroxyC1-6alkyloxy, hydroxyC1-6alkylthio and arylC1-6alkylthio; R3 is aryl, —NR5R6, a substituted or unsubstituted C1-14heterocycle, or C2-4alkenediyl substituted with a substituted or unsubstituted C1-14heterocycle or aryl; R4 is hydrogen, aryl, C3-7cycloalkyl, C1-6alkyl or C1-6alkyl substituted with C3-7cycloalkyl, hydroxycarbonyl, C1-4alkyloxycarbonyl or aryl; R5 and R6 are each independently selected from hydrogen, a substituted or unsubstituted C1-14heterocycle, aryl, C1-12alkyl and C1-12alkyl substituted with one or more substituents selected from hydroxy, aryl, aryloxy or a substituted or unsubstituted C1-14heterocycle.

公开(公告)号：US20050155177A1

公开(公告)日：2005-07-21

申请号：US11007414

申请日：2004-12-08

申请人： Mark Baer ,  Li Liu ,  Jonathan Miller

发明人： Mark Baer ,  Li Liu ,  Jonathan Miller

IPC分类号： A47L5/00 ,  A47L5/36 ,  A47L9/00 ,  A47L9/28

CPC分类号： A47L5/365 ,  A47L9/2873 ,  A47L9/2878 ,  A47L9/2884

摘要： A vacuum cleaner includes a tank having a bottom and an inlet for receiving debris, a motor assembly disposed adjacent to the tank, the motor assembly adapted to draw debris into the tank through the inlet, a battery pack disposed adjacent the bottom of the tank, and a connection from the battery pack to the motor assembly that is adapted to carry current between the battery pack and the motor assembly. The battery pack includes at least one battery and supplies power to the motor assembly.

摘要翻译： 真空吸尘器包括具有底部和用于接收碎屑的入口的容器，邻近所述罐设置的马达组件，所述马达组件适于通过所述入口将碎屑吸入所述罐中，邻近所述罐的底部设置的电池组， 以及从电池组到电动机组件的连接，其适于在电池组和电动机组件之间承载电流。 电池组包括至少一个电池，并向马达组件供电。

公开(公告)号：USD498236S1

公开(公告)日：2004-11-09

申请号：US29174846

申请日：2003-01-24

申请人： Li Liu ,  Theodore J. Colburn ,  Xu Zhang

设计人： Li Liu ,  Theodore J. Colburn ,  Xu Zhang

公开(公告)号：USD491186S1

公开(公告)日：2004-06-08

申请号：US29171704

申请日：2002-11-27

申请人： James S. Arakaki ,  Jorge M. Fernandes ,  Li Liu

设计人： James S. Arakaki ,  Jorge M. Fernandes ,  Li Liu

公开(公告)号：US06337408B1

公开(公告)日：2002-01-08

申请号：US09533368

申请日：2000-03-22

申请人： Andrew Allen ,  Ann Marie Diederich ,  Li Liu ,  Wilford Mendelson ,  Kevin Webb

发明人： Andrew Allen ,  Ann Marie Diederich ,  Li Liu ,  Wilford Mendelson ,  Kevin Webb

IPC分类号： C07D30300

CPC分类号： C07D303/48 ,  C07C253/30 ,  C07C2601/08 ,  C07C2601/14 ,  C07C255/46

摘要： This invention relates to a method of preparing a compound of the following type by treating a compound of formula (II) with lithium bromide, magnesium bromide and the like.

摘要翻译： 本发明涉及通过用溴化锂，溴化镁等处理式（II）化合物来制备下列化合物的方法。

公开(公告)号：USD995854S1

公开(公告)日：2023-08-15

申请号：US29817548

申请日：2021-12-02

申请人： Li Liu

设计人： Li Liu ,  Lirui Tian ,  Weifeng Huang ,  Pian Wang

摘要： FIG. 1 is a top, front and right side perspective view of a mini computer showing our new design;
FIG. 2 is a bottom, rear and left side perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines in the drawings illustrate portions of the mini computer which form no part of the claimed design.

公开(公告)号：US11491544B2

公开(公告)日：2022-11-08

申请号：US16771148

申请日：2020-01-19

申请人： Li Liu

发明人： Li Liu

IPC分类号： B22F9/16 ,  B22F1/05 ,  B22F1/065

摘要： The present disclosure provides a preparation method of a metal powder material. An alloy sheet composed of a matrix phase and a dispersive phase with different chemical reactivities is prepared by the rapid solidification technique of alloy melt. Metal powder is prepared by the reaction of the alloy sheet and an acid solution. Please refer to the description for the detailed preparation method. This method is simple in operation, can be used to prepare many kinds of metal powder materials of different shapes and at the nanometer scale, the submicron scale and the micron scale, and has a good application prospect in the fields of catalysis, powder metallurgy and 3D printing.