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    Crystalline forms of 3-(imidazo[1,2-B] pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt
    88.
    发明授权
    Crystalline forms of 3-(imidazo[1,2-B] pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt 有权
    3-（咪唑并[1,2-B]哒嗪-3-基乙炔基）-4-甲基-N- {4 - [（4-甲基哌嗪-1-基）甲基] -3-（三氟甲基）苯基} 苯甲酰胺及其单盐酸盐

    公开(公告)号：US09493470B2

    公开(公告)日：2016-11-15

    申请号：US14651577

    申请日：2013-12-12

    申请人： ARIAD Pharmaceuticals, Inc.

    发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep Sharma

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04 ,  C07B2200/13

    摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyljbenzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methyl piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein. The instant application is directed to novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl}phenyl}benzamide and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, compositions comprising such crystalline forms, and to methods of their preparation and use.

    摘要翻译： 3-（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N- {4 - [（4-甲基哌嗪-1-基）甲基] -3-（三氟甲基）苯基]苯甲酰胺的新结晶形式 游离碱和3-（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N- {4 - [（4-甲基哌嗪-1-基）甲基] -3-（三氟甲基）苯基 }苯甲酰胺单盐酸盐，其药物组合物及其制备和用途的方法。 本申请涉及3-（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N- {4 - [（4-甲基哌嗪-1-基）甲基] - 3-（三氟甲基）苯基}苯甲酰胺和3-（咪唑并[1,2-b]哒嗪-3-基乙炔基）-4-甲基-N- {4 - [（4-甲基哌嗪-1-基）甲基] -3 - （三氟甲基）苯基}苯甲酰胺单盐酸盐，包含这种结晶形式的组合物及其制备和使用方法。