公开(公告)号：US10662197B2

公开(公告)日：2020-05-26

申请号：US16146143

申请日：2018-09-28

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US20240083902A1

公开(公告)日：2024-03-14

申请号：US18175272

申请日：2023-02-27

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  C07B2200/13 ,  H05K999/99

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US11384086B2

公开(公告)日：2022-07-12

申请号：US17318876

申请日：2021-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US11192897B2

公开(公告)日：2021-12-07

申请号：US17318832

申请日：2021-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US11192896B2

公开(公告)日：2021-12-07

申请号：US17318772

申请日：2021-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US20210277012A1

公开(公告)日：2021-09-09

申请号：US17318832

申请日：2021-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US20210277011A1

公开(公告)日：2021-09-09

申请号：US17318772

申请日：2021-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US20210277010A1

公开(公告)日：2021-09-09

申请号：US17318677

申请日：2021-05-12

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.

公开(公告)号：US20210186994A1

公开(公告)日：2021-06-24

申请号：US17193502

申请日：2021-03-05

申请人： Ariad Pharmaceuticals, Inc.

发明人： Dauntel S. Verwijs ,  Samir Desai ,  Pradeep K. Sharma ,  Leonard W. Rozamus ,  Jeff Williamson ,  Danica Cartwright ,  Parag Ved

IPC分类号： A61K31/675 ,  A61K9/20 ,  A61K9/28 ,  A61K31/662 ,  A61P35/00

摘要： This invention relates to a pharmaceutical composition comprising 5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine as the active pharmaceutical ingredient, and therapeutic uses of the pharmaceutical formulation. In particular, the invention is directed to tablets comprising the pharmaceutical composition, methods of preparing the tablets, and therapeutic uses thereof.

公开(公告)号：US11279705B2

公开(公告)日：2022-03-22

申请号：US16881790

申请日：2020-05-22

申请人： ARIAD Pharmaceuticals, Inc.

发明人： Christopher K. Murray ,  Leonard W. Rozamus ,  John J. Chaber ,  Pradeep K. Sharma

IPC分类号： C07D487/04

摘要： Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.