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公开(公告)号:US20220033392A1
公开(公告)日:2022-02-03
申请号:US17226531
申请日:2021-04-09
发明人: Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Xiaotian Zhu
IPC分类号: C07D417/12 , C07D417/04 , C07D277/46
摘要: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: wherein A, L, R1, R2, R3, and n are described herein.
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公开(公告)号:US20200231588A1
公开(公告)日:2020-07-23
申请号:US16722881
申请日:2019-12-20
发明人: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号: C07D471/04 , C07D473/34 , C07D487/04
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号:US20130231337A1
公开(公告)日:2013-09-05
申请号:US13801116
申请日:2013-03-13
发明人: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号: C07D487/04 , C07D473/34 , C07D471/04
CPC分类号: C07D471/04 , C07D473/34 , C07D487/04
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译: 本发明涉及以下通式的化合物:其中可变基团如本文所定义,及其制备和用途。
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公开(公告)号:US11117883B2
公开(公告)日:2021-09-14
申请号:US16469535
申请日:2017-12-14
发明人: Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Yun Zhang , Xiaotian Zhu
IPC分类号: A61K31/4184 , A61K31/4178 , A61K31/4439 , A61K31/4427 , C07D403/14 , C07D403/12 , C07D403/04 , C07D401/14 , C07D401/12 , C07D413/14 , C07D405/14
摘要: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other serine-threonine kinase mediated diseases, having the Formula: (I) where A, L, R1, R2, R3, and n are described herein.
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公开(公告)号:US11001580B2
公开(公告)日:2021-05-11
申请号:US16469517
申请日:2017-12-14
发明人: Nicholas E. Bencivenga , David C. Dalgarno , Joseph M. Gozgit , Wei-Sheng Huang , Anna Kohlmann , Feng Li , Jiwei Qi , William C. Shakespeare , Ranny M. Thomas , Yihan Wang , Xiaotian Zhu
IPC分类号: C07D417/14 , C07D417/12
摘要: The invention relates to c-Kit inhibitors useful in the treatment of cancers, and other-threonine kinase mediated diseases, having the Formula: (I) wherein A, L, R1, R2, R3, and n are described herein.
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公开(公告)号:US20190031656A1
公开(公告)日:2019-01-31
申请号:US16055362
申请日:2018-08-06
发明人: Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号: C07D471/04 , C07D473/34 , C07D487/04
摘要: This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号:US09573934B2
公开(公告)日:2017-02-21
申请号:US14607831
申请日:2015-01-28
发明人: Feng Li , Yihan Wang
IPC分类号: C07D211/60 , C07C51/06 , C07C209/08 , C07C231/02 , C07C235/34 , C07D205/04 , C07D319/06 , C07D401/12 , C07D319/04 , C07B53/00 , C07C209/62 , C07C209/74 , C07C231/18
CPC分类号: C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要: The invention features methods and compositions for the synthesis of multimerizing agents.
摘要翻译: 本发明的特征在于用于合成多聚化剂的方法和组合物。
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8.
公开(公告)号:US20150148543A1
公开(公告)日:2015-05-28
申请号:US14607831
申请日:2015-01-28
发明人: Feng Li , Yihan Wang
IPC分类号: C07D401/12 , C07D205/04 , C07C231/02 , C07C51/06 , C07C209/08 , C07D319/06 , C07C235/34
CPC分类号: C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要: The invention features methods and compositions for the synthesis of multimerizing agents.
摘要翻译: 本发明的特征在于用于合成多聚化剂的方法和组合物。
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公开(公告)号:US09834521B2
公开(公告)日:2017-12-05
申请号:US14774359
申请日:2014-03-13
发明人: Stephan G. Zech , Anna Kohlmann , Feng Li , Yihan Wang , Tianjun Zhou , David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu
IPC分类号: C07D243/08 , A61K31/551 , C07D401/10 , C07D403/10 , C07D417/10 , C07D245/02 , C07D401/14 , C07D403/14 , C07D413/10 , C07D413/14 , C07F9/645
CPC分类号: C07D243/08 , A61K31/551 , C07D245/02 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07F9/645
摘要: This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.
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10.
公开(公告)号:US20160244469A1
公开(公告)日:2016-08-25
申请号:US15044382
申请日:2016-02-16
IPC分类号: C07F9/6512 , C07F9/6584 , C07D239/42 , C07D403/12 , C07F9/6558 , C07F9/6521
CPC分类号: C07F9/6512 , A61K31/505 , A61K31/506 , A61K31/675 , A61K45/06 , C07D239/42 , C07D239/48 , C07D403/12 , C07F9/28 , C07F9/6521 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/6584 , C07F9/65846
摘要: The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of Formula I: wherein the variables are as defined herein.
摘要翻译: 本发明的特征在于用于治疗患有EGFR驱动的式I的癌症的患者的化合物,药物组合物和方法:其中变量如本文所定义。
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