公开(公告)号：US06565831B1

公开(公告)日：2003-05-20

申请号：US09636597

申请日：2000-08-10

申请人： Matthew C. Coffey ,  Bradley G. Thompson

发明人： Matthew C. Coffey ,  Bradley G. Thompson

IPC分类号： A61K4800

CPC分类号： A61K35/765 ,  A61K38/13 ,  C07K16/081 ,  C07K16/10 ,  C07K16/4216 ,  C12N9/1205 ,  C12N2720/12232 ,  Y10S435/948 ,  Y10S435/975 ,  A61K2300/00

摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells.

摘要翻译： 本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。 该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。 所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。 或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。

公开(公告)号：US20030039656A1

公开(公告)日：2003-02-27

申请号：US10211218

申请日：2002-08-02

发明人： Jeffrey Tarrand ,  Xiang-Yang Han

IPC分类号： A61K039/395 ,  A61K039/15

CPC分类号： A61K35/765 ,  A61K47/6901 ,  C12N2720/12232

摘要： The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.

摘要翻译： 本发明涉及过度增生性疾病。 具体地说，本发明包括包含修饰的呼肠弧病毒病毒的药物组合物，其中病毒科病毒与羟基化烃或聚阳离子聚合物结合以减少组合物的清除率并降低组合物的免疫原性。 此外，本发明涉及通过向患者施用有效量的经修饰的病毒科病毒来治疗过度增殖性疾病的方法。

公开(公告)号：US20030003080A1

公开(公告)日：2003-01-02

申请号：US10218452

申请日：2002-08-15

发明人： Patrick W.K. Lee ,  James Strong ,  Matthew C. Coffey

IPC分类号： A61K048/00 ,  C12N015/86

CPC分类号： A61K9/0019 ,  A61K35/765 ,  C12N2720/12032 ,  C12N2720/12232

摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

公开(公告)号：US20020168344A1

公开(公告)日：2002-11-14

申请号：US10076074

申请日：2002-02-15

申请人： Oncolytics Biotech, Inc.

发明人： Matthew C. Coffey ,  Bradley G. Thompson

IPC分类号： A61K048/00 ,  A61K038/21 ,  A61K031/704 ,  A61K031/66 ,  A61K031/525

CPC分类号： A61K33/24 ,  A61K35/765 ,  A61K45/06 ,  C12N2720/12232 ,  A61K2300/00

摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus.

摘要翻译： 本发明涉及通过使用病毒增加肿瘤细胞对化学治疗剂的敏感性的方法，使用病毒和化学治疗剂治疗增殖性病症的方法以及预防肿瘤对化疗药物的耐药性的方法。 病毒优选为呼肠孤病毒。

公开(公告)号：US06455038B1

公开(公告)日：2002-09-24

申请号：US09594343

申请日：2000-06-15

申请人： Patrick W. K. Lee ,  James Strong ,  Matthew C. Coffey

发明人： Patrick W. K. Lee ,  James Strong ,  Matthew C. Coffey

IPC分类号： A61K3576

CPC分类号： A61K9/0019 ,  A61K35/765 ,  C12N2720/12032 ,  C12N2720/12232

摘要： Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

摘要翻译： 公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。 施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒，则可以使用血清型1（例如，菌株Lang），血清型2（例如菌株琼斯），血清型3（例如，菌株Dearing或菌株Abney）以及呼肠孤病毒的其它血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合，以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

公开(公告)号：US20020061298A1

公开(公告)日：2002-05-23

申请号：US09987687

申请日：2001-11-15

发明人： Matthew C. Coffey ,  Bradley G. Thompson

IPC分类号： A61K048/00 ,  C12N007/01

CPC分类号： A61K35/765 ,  C12N2720/12232

摘要： This invention relates to a method for optimally delivering virus to a solid tumor. Two approaches can be adopted to increase the number of tumor cells inside the solid tumor which are exposed to virus. The virus can be delivered to multiple sites inside the solid tumor, or the virus can be delivered to a single site in such a large volume that the delivered virus is capable of reaching more tumor cells in the solid tumor.

摘要翻译： 本发明涉及一种将病毒最佳传播至实体肿瘤的方法。 可以采用两种方法来增加暴露于病毒的实体瘤内的肿瘤细胞数。 病毒可以传递到实体瘤内的多个部位，或者病毒可以以如此大的体积递送到单个部位，使得递送的病毒能够到达实体肿瘤中更多的肿瘤细胞。

公开(公告)号：US20010048920A1

公开(公告)日：2001-12-06

申请号：US09852017

申请日：2001-05-10

发明人： Patrick W.K. Lee ,  James Strong ,  Matthew C. Coffey

IPC分类号： A61K048/00

CPC分类号： C12N9/1205 ,  A61K35/765 ,  C12N7/00 ,  C12N2720/12232 ,  C12N2720/12261

摘要： Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other sterotypes or strains of reovirus can be used. Combinations of more than one type and/or strain or reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

摘要翻译： 公开了通过向Ras介导的肿瘤施用呼肠孤病毒和使用呼肠孤病毒来制造用于治疗肿瘤的药物的方法。 呼肠病毒的施用使其最终直接接触肿瘤细胞。 可以使用人呼肠病毒，非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒，可以使用1型（例如，菌株Lang），2型（例如菌株琼斯），3型（例如，菌株Dearing或菌株Abney）以及其它定向型或呼肠孤病毒菌株。 可以使用多于一种类型和/或菌株或呼肠孤病毒的组合，以及来自不同动物种的呼肠病毒。 可以治疗实体肿瘤或造血赘生物。