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公开(公告)号：US20130273012A1
公开(公告)日：2013-10-17
申请号：US13903236
申请日：2013-05-28
IPC分类号： C12N5/078
CPC分类号： C12N5/0634 , A61K35/28 , A61K35/761 , A61K35/768 , C12N2720/12032
摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.
摘要翻译： 本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。 在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。 还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。
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公开(公告)号：US08491886B2
公开(公告)日：2013-07-23
申请号：US13297384
申请日：2011-11-16
CPC分类号： A61K35/76 , A61K35/13 , C12N2710/10032
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译： 公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。 施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。 增生性疾病包括但不限于赘生物。 病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。 还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。
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公开(公告)号：US07964186B2
公开(公告)日：2011-06-21
申请号：US11807920
申请日：2007-05-30
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
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4.发明申请Reovirus Clearance of Ras-Mediated Neoplastic Cells from Mixed Cellular Compositions 有权来自混合细胞组合物的Ras介导的肿瘤细胞的呼肠孤病毒清除公开(公告)号：US20100248205A1
公开(公告)日：2010-09-30
申请号：US12726002
申请日：2010-03-17
CPC分类号： C12N5/0093 , A61K35/28 , A61K35/765 , A61K48/00 , A61L2/00 , C12N5/0693 , C12N7/00 , C12N15/86 , C12N2720/12032 , C12N2720/12211 , C12N2720/12232 , C12N2720/12243 , Y10T436/25
摘要： Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
摘要翻译： 呼肠病毒可用于从细胞组合物中选择性地除去ras介导的肿瘤细胞。 特别值得注意的是，将携带呼吸病毒的肿瘤细胞移植到接受者之前清除携带肿瘤细胞的亲本，从而降低将肿瘤细胞引入或重新引入接受者的风险。
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公开(公告)号：US20100105122A1
公开(公告)日：2010-04-29
申请号：US12652289
申请日：2010-01-05
IPC分类号： C12N7/00
CPC分类号： G01N33/574 , G01N33/5748 , G01N2333/14 , Y10S435/975
摘要： The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
摘要翻译： 本发明提供了通过使用在具有特定表型的肿瘤中选择性复制的溶瘤病毒来诊断具有特定表型的赘生物的方法。 例如，呼肠孤病毒不会在正常细胞中复制。 然而，呼肠孤病毒在具有活化的ras途径的细胞中选择性复制，这导致这些细胞的死亡。 因此，由于至少部分地升高的ras途径活性而变得肿瘤的细胞可以通过其对呼肠孤病毒复制的易感性来诊断。 本发明还可以使用其他溶瘤病毒来应用于其它肿瘤如干扰素敏感性肿瘤，p53缺陷型肿瘤和Rb缺陷型肿瘤的诊断和/或治疗。 还提供了在本文公开的诊断或治疗中有用的试剂盒。
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公开(公告)号：US07608257B2
公开(公告)日：2009-10-27
申请号：US11809293
申请日：2007-05-31
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus.
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公开(公告)号：US07582289B2
公开(公告)日：2009-09-01
申请号：US11807906
申请日：2007-05-30
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
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公开(公告)号：US07306902B2
公开(公告)日：2007-12-11
申请号：US10602024
申请日：2003-06-24
CPC分类号： G01N33/574 , G01N33/5748 , G01N2333/14 , Y10S435/975
摘要： The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death of these cells. Therefore, a cell which becomes neoplastic due to, at least in part, elevated ras pathway activities can be diagnosed by its susceptibility to reovirus replication. This invention can further be applied, using other oncolytic viruses, to the diagnosis and/or treatment of other tumors, such as interferon-sensitive tumors, p53-deficient tumors and Rb-deficient tumors. Kits useful in the diagnosis or treatment disclosed herein are also provided.
摘要翻译： 本发明提供了通过使用在具有特定表型的肿瘤中选择性复制的溶瘤病毒来诊断具有特定表型的赘生物的方法。 例如，呼肠孤病毒不会在正常细胞中复制。 然而，呼肠孤病毒在具有活化的ras途径的细胞中选择性复制，这导致这些细胞的死亡。 因此，由于至少部分地升高的ras途径活性而变得肿瘤的细胞可以通过其对呼肠孤病毒复制的易感性来诊断。 本发明还可以使用其他溶瘤病毒来应用于其它肿瘤如干扰素敏感性肿瘤，p53缺陷型肿瘤和Rb缺陷型肿瘤的诊断和/或治疗。 还提供了在本文公开的诊断或治疗中有用的试剂盒。
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公开(公告)号：US07049127B2
公开(公告)日：2006-05-23
申请号：US10734552
申请日：2003-12-11
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051
摘要： A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus.
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10.发明授权Abrogating proinflammatory cytokine production during oncolytic reovirus therapy 有权在溶瘤性呼肠孤病毒治疗期间消除促炎细胞因子产生公开(公告)号：US08470312B2
公开(公告)日：2013-06-25
申请号：US12994114
申请日：2009-05-27
CPC分类号： A61K35/765 , A61K31/282 , A61K31/555 , A61K33/24 , C12N2720/12032 , A61K2300/00
摘要： Provided herein are methods for treating a proliferative disorder in a subject comprising administering to the subject one or more reoviruses and one or more agents that modulate expression or activity of pro-inflammatory cytokines. For example, the agents may inhibit expression or activity of pro-inflammatory cytokines.
摘要翻译： 本文提供了治疗受试者中增殖性病症的方法，包括向受试者施用一种或多种呼肠孤病毒和一种或多种调节促炎细胞因子的表达或活性的试剂。 例如，该试剂可抑制促炎细胞因子的表达或活性。
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