公开(公告)号：US07466085B2

公开(公告)日：2008-12-16

申请号：US11736032

申请日：2007-04-17

申请人： Ronald Nutt

发明人： Ronald Nutt

IPC分类号： H05H13/00

CPC分类号： H05H13/00

摘要： An apparatus for an improved cyclotron for producing radioisotopes especially for use in association with medical imaging. The improved cyclotron is configured without a conventional electromagnetic coil. A plurality of dees and a plurality of permanent magnets are alternately disposed in a circular array, each defining a channel through which ions travel. The vacuum chamber wall defines an opening disposed at the center of the array, the opening being configured to receive an ion source. Positive ions flowing from the ion source are exposed to the magnetic field generated by permanent magnets. The positive ions are repelled as they exit a positively charged dee. Negatively charged dees pull the ions. Each time the particles pass through the gap approaching the dees and as they leave the dee and pass through the magnets, they gain energy, so the orbital radius continuously increases and the particles follow an outwardly spiraling path. The disclosure also includes a system composed of a particle accelerator combined with a microreactor or microfluidic chip to produce molecular imaging biomarkers.

摘要翻译： 用于改进的回旋加速器用于生产放射性同位素的装置，特别是用于与医学成像相关联。 改进的回旋加速器被配置成没有传统的电磁线圈。 多个圆环和多个永磁体交替地设置在圆形阵列中，每个定义了离子移动通过的通道。 真空室壁限定了设置在阵列中心的开口，该开口构造成接收离子源。 从离子源流出的正离子暴露于由永磁体产生的磁场。 当正离子离开带正电荷的原子时，正离子被排斥。 负电荷的dees拉离子。 每次颗粒通过靠近脚趾的间隙，并且当它们离开趾部并穿过磁体时，它们获得能量，因此轨道半径连续增加，并且颗粒沿着向外螺旋的路径。 本公开还包括由与微反应器或微流体芯片结合的颗粒加速器组成的系统，以产生分子成像生物标志物。

公开(公告)号：US07476883B2

公开(公告)日：2009-01-13

申请号：US11441999

申请日：2006-05-26

申请人： Ronald Nutt

发明人： Ronald Nutt

IPC分类号： H05H9/00 ,  G21G1/10

CPC分类号： G21G4/08 ,  G21G1/0005 ,  G21G1/10 ,  G21H5/02 ,  H05H13/005

摘要： A biomarker generator system for producing approximately one (1) unit dose of a biomarker. The biomarker generator system includes a small, low-power particle accelerator (“micro-accelerator”) and a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip. The micro-accelerator is provided for producing approximately one (1) unit dose of a radioactive substance, such as a substance that emits positrons. The radiochemical synthesis subsystem is provided for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a biomarker.

摘要翻译： 生物标志物发生器系统，用于生产大约一（1）个单位剂量的生物标志物。 生物标志物发生器系统包括具有至少一个微反应器和/或微流体芯片的小型低功率粒子加速器（“微加速器”）和放射化学合成子系统。 提供微促进剂用于产生大约一（1）单位剂量的放射性物质，例如发射正电子的物质。 提供放射化学合成子系统用于接收放射性物质，用于接收至少一种试剂，并用于合成大约一（1）单位剂量的生物标志物。

公开(公告)号：US20090218520A1

公开(公告)日：2009-09-03

申请号：US12333300

申请日：2008-12-11

申请人： Ronald Nutt

发明人： Ronald Nutt

IPC分类号： G21G4/00

CPC分类号： G21G1/0005 ,  G21H5/02 ,  H05H13/00

摘要： A low-volume biomarker generator for producing ultra-short lived radiopharmaceuticals. The low-volume biomarker generator system includes a low-power cyclotron and a radiochemical synthesis system. The cyclotron of the low-volume biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in small quantities down to approximately one (1) unit dose. The cyclotron incorporates permanent magnets in place of electromagnets and/or an improved rf system to reduce the size, power requirements, and weight of the cyclotron. The radiochemical synthesis system of the low-volume biomarker is a small volume system optimized for synthesizing the radiopharmaceutical in small quantities of approximately one (1) unit dose.

摘要翻译： 用于生产超短寿命放射性药物的低体积生物标志物发生器。 低体积生物标志物发生器系统包括低功率回旋加速器和放射化学合成系统。 针对低体积生物标志物发生器的回旋加速器进行了优化，用于生产放射性同位素，可用于合成低至大约一（1）单位剂量的放射性药物。 回旋加速器结合永磁体代替电磁体和/或改进的射频系统，以减小回旋加速器的尺寸，功率要求和重量。 低体积生物标志物的放射化学合成系统是一种小体积系统，其优化用于以大约一（1）个单位剂量的少量合成放射性药物。

公开(公告)号：US20080258653A1

公开(公告)日：2008-10-23

申请号：US11736032

申请日：2007-04-17

申请人： Ronald Nutt

发明人： Ronald Nutt

IPC分类号： H05H13/00

CPC分类号： H05H13/00

摘要： An apparatus for an improved cyclotron for producing radioisotopes especially for use in association with medical imaging. The improved cyclotron is configured without a conventional electromagnetic coil. A plurality of dees and a plurality of permanent magnets are alternately disposed in a circular array, each defining a channel through which ions travel. The vacuum chamber wall defines an opening disposed at the center of the array, the opening being configured to receive an ion source. Positive ions flowing from the ion source are exposed to the magnetic field generated by permanent magnets. The positive ions are repelled as they exit a positively charged dee. Negatively charged dees pull the ions. Each time the particles pass through the gap approaching the dees and as they leave the dee and pass through the magnets, they gain energy, so the orbital radius continuously increases and the particles follow an outwardly spiraling path. The disclosure also includes a system composed of a particle accelerator combined with a microreactor or microfluidic chip to produce molecular imaging biomarkers.

摘要翻译： 用于改进的回旋加速器用于生产放射性同位素的装置，特别是用于与医学成像相关联。 改进的回旋加速器被配置成没有传统的电磁线圈。 多个圆环和多个永磁体交替地设置在圆形阵列中，每个定义了离子移动通过的通道。 真空室壁限定了设置在阵列中心的开口，该开口构造成接收离子源。 从离子源流出的正离子暴露于由永磁体产生的磁场。 当正离子离开带正电荷的原子时，正离子被排斥。 负电荷的dees拉离子。 每次颗粒通过靠近脚趾的间隙，并且当它们离开趾部并穿过磁体时，它们获得能量，因此轨道半径连续增加，并且颗粒沿着向外螺旋的路径。 本公开还包括由与微反应器或微流体芯片结合的颗粒加速器组成的系统，以产生分子成像生物标志物。

公开(公告)号：US07884340B2

公开(公告)日：2011-02-08

申请号：US12333300

申请日：2008-12-11

申请人： Ronald Nutt

发明人： Ronald Nutt

IPC分类号： G21G1/10

CPC分类号： G21G1/0005 ,  G21H5/02 ,  H05H13/00

摘要： A low-volume biomarker generator for producing ultra-short lived radiopharmaceuticals. The low-volume biomarker generator system includes a low-power cyclotron and a radiochemical synthesis system. The cyclotron of the low-volume biomarker generator is optimized for producing radioisotopes useful in synthesizing radiopharmaceuticals in small quantities down to approximately one (1) unit dose. The cyclotron incorporates permanent magnets in place of electromagnets and/or an improved rf system to reduce the size, power requirements, and weight of the cyclotron. The radiochemical synthesis system of the low-volume biomarker is a small volume system optimized for synthesizing the radiopharmaceutical in small quantities of approximately one (1) unit dose.

摘要翻译： 用于生产超短寿命放射性药物的低体积生物标志物发生器。 低体积生物标志物发生器系统包括低功率回旋加速器和放射化学合成系统。 针对低体积生物标志物发生器的回旋加速器进行了优化，用于生产放射性同位素，可用于合成低至大约一（1）个单位剂量的放射性药物。 回旋加速器结合永磁体代替电磁体和/或改进的射频系统，以减小回旋加速器的尺寸，功率要求和重量。 低体积生物标志物的放射化学合成系统是一种小体积系统，其优化用于以大约一（1）个单位剂量的少量合成放射性药物。

公开(公告)号：US20080067413A1

公开(公告)日：2008-03-20

申请号：US11441999

申请日：2006-05-26

申请人： Ronald Nutt

发明人： Ronald Nutt

IPC分类号： G21G1/10

CPC分类号： G21G4/08 ,  G21G1/0005 ,  G21G1/10 ,  G21H5/02 ,  H05H13/005

摘要： A biomarker generator system for producing approximately one (1) unit dose of a biomarker. The biomarker generator system includes a small, low-power particle accelerator (“micro-accelerator”) and a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip. The micro-accelerator is provided for producing approximately one (1) unit dose of a radioactive substance, such as a substance that emits positrons. The radiochemical synthesis subsystem is provided for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a biomarker.

摘要翻译： 生物标志物发生器系统，用于生产大约一（1）个单位剂量的生物标志物。 生物标志物发生器系统包括具有至少一个微反应器和/或微流体芯片的小型低功率粒子加速器（“微加速器”）和放射化学合成子系统。 提供微促进剂用于产生大约一（1）单位剂量的放射性物质，例如发射正电子的物质。 提供放射化学合成子系统用于接收放射性物质，用于接收至少一种试剂，并用于合成大约一（1）单位剂量的生物标志物。