公开(公告)号：US20240339235A1

公开(公告)日：2024-10-10

申请号：US18745896

申请日：2024-06-17

申请人： Curium US LLC

发明人： Brian Regna ,  Allan Casciola ,  Lauren Radford ,  Shaun Loveless ,  David Pipes ,  William Uhland ,  Craig Brunkhorst

IPC分类号： G21G1/00 ,  A61K51/04 ,  C01G3/00 ,  G21G1/10 ,  G21G4/08

CPC分类号： G21G1/001 ,  A61K51/0482 ,  C01G3/003 ,  G21G1/10 ,  G21G4/08 ,  G21G2001/0094

摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

公开(公告)号：US11986815B2

公开(公告)日：2024-05-21

申请号：US17413146

申请日：2019-12-10

申请人： SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES ET GÉNIE S.E.C.

发明人： Brigitte Guerin ,  Sebastien Tremblay ,  Samia Ait-Mohand ,  Aiman H. Alnahwi

IPC分类号： B01J47/026 ,  A61B6/03 ,  A61K51/08 ,  B01J39/26 ,  G21G1/00 ,  G21G1/10

CPC分类号： B01J47/026 ,  A61K51/083 ,  B01J39/26 ,  A61B6/037 ,  G21G2001/0021 ,  G21G1/10

摘要： The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of 68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of 68Ga. In additional embodiments, the process is implemented by an automated system.

公开(公告)号：US11887745B2

公开(公告)日：2024-01-30

申请号：US17960279

申请日：2022-10-05

申请人： Gregory Gaehle

发明人： Gregory Gaehle

IPC分类号： G21G1/10 ,  H05H6/00 ,  G21K5/08 ,  G21G1/00

CPC分类号： G21G1/10 ,  G21K5/08 ,  H05H6/00 ,  G21G2001/0094

摘要： Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area, resulting in improved specific activity while reducing the amount of target material used.

公开(公告)号：US11798700B2

公开(公告)日：2023-10-24

申请号：US17040652

申请日：2019-03-26

申请人： TRIUMF Inc. ,  THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Andrew Kyle Henderson Robertson ,  Hua Yang ,  Stefan Zeisler ,  Paul Schaffer

IPC分类号： G21G1/00 ,  G21G1/10 ,  B01D5/00 ,  C01B15/047 ,  C01F17/13 ,  B01D15/18 ,  B01D15/36

CPC分类号： G21G1/001 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/363 ,  C01B15/0475 ,  C01F17/13 ,  G21G1/10 ,  G21G2001/0089 ,  G21G2001/0094

摘要： A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.

公开(公告)号：US11783957B2

公开(公告)日：2023-10-10

申请号：US16824342

申请日：2020-03-19

申请人： SUMITOMO HEAVY INDUSTRIES, LTD.

发明人： Hiroyuki Uno ,  Shigeharu Ochi ,  Francisco Guerra Gomez

IPC分类号： G21K5/08 ,  G21G1/10

CPC分类号： G21K5/08 ,  G21G1/10

摘要： A liquid target device includes a liquid accommodation portion in which a target liquid is accommodated, a beam passage through which a charged particle beam emitted from a particle accelerator passes to reach the liquid accommodation portion, a target foil that separates the beam passage and the liquid accommodation portion from each other, and a vacuum foil that separates a vacuum region provided upstream of the beam passage and the beam passage from each other. The beam passage is provided with a first gas chamber into which a cooling gas is supplied at a position on the vacuum foil side and a second gas chamber into which a cooling gas is supplied at a position closer to the target foil side than the first gas chamber and the first gas chamber and the second gas chamber are separated from each other by an intermediate foil.

公开(公告)号：US11638839B2

公开(公告)日：2023-05-02

申请号：US17088714

申请日：2020-11-04

申请人： Peking University

发明人： Jungao Zhu ,  Xueqing Yan ,  Chen Lin

IPC分类号： A61N5/10 ,  G01T1/29 ,  G21K5/04 ,  G21G1/10

摘要： A device and a method for measuring proton beam source position and beamline center are disclosed. The device includes N quadrupole magnets, a laser, a target and a scintillation screen; the target and the scintillation screen are arranged in front of and behind the N-quadrupole lens, respectively; the N-quadrupole lens can be converted to a M-quadrupole lens; the position of proton beam after being focused by the N- or M-quadrupole lens on the scintillation screen is measured; according to the amplification factor and the proton beam position, the offset of the proton beam source from the beamline center, as well as the position of the beamline center on the scintillation screen are calculated; the disclosure can accurately determine the position of the beamline center and the proton beam source by the use of N quadrupole magnets, combined with a scintillation screen.

公开(公告)号：US20230081594A1

公开(公告)日：2023-03-16

申请号：US17993186

申请日：2022-11-23

申请人： Curium US LLC

发明人： David Pipes ,  Lauren Radford ,  William Uhland ,  Brian Regna ,  Craig Brunkhorst

IPC分类号： G21G1/00 ,  G21G4/08 ,  A61K51/04 ,  C01G3/00 ,  G21G1/10

摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

公开(公告)号：US20230048265A1

公开(公告)日：2023-02-16

申请号：US17816965

申请日：2022-08-02

申请人： Baltelle Energy Alliance, LLC

发明人： Justin T. Cooper ,  ARIANA A. FOLEY ,  MATHEW S. SNOW ,  JESSICA L. MEIERS ,  MATHEW T. KINLAW

IPC分类号： G21G1/10 ,  G21G1/00

摘要： A method for producing a radionuclide comprises irradiating a target material with a linear accelerator to produce a radionuclide, dissolving the irradiated target material comprising the radionuclide, and separating the radionuclide from the irradiated target material. Additional methods are disclosed.

公开(公告)号：US11581103B2

公开(公告)日：2023-02-14

申请号：US17894874

申请日：2022-08-24

申请人： CURIUM US LLC

发明人： David Pipes ,  Lauren Radford ,  William Uhland ,  Brian Regna ,  Craig Brunkhorst

IPC分类号： G21G1/00 ,  G21G1/10 ,  A61K51/04 ,  C01G3/00 ,  G21G4/08

摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

公开(公告)号：US20230041327A1

公开(公告)日：2023-02-09

申请号：US17444483

申请日：2021-08-05

申请人： Texas Thorium LLC

发明人： Holloway H. Frost ,  Rodolfo Vaghetto ,  Yassin A. Hassan ,  Lin Shao ,  Trevor D. Parker

IPC分类号： G21G1/08 ,  G21G1/10 ,  G21C3/54

摘要： A method of generating power using a Thorium-containing molten salt fuel is disclosed. One example of the disclosed method includes the steps of providing a vessel containing a molten salt fuel, the molten salt fuel comprising Thorium and at least one salt containing a nucleus capable of interacting with a proton of sufficient energy to produce a (p, n) reaction resulting in the generation of a neutron at a first energy level and generating a proton beam externally to the vessel, where the externally generated proton beam being of an energy level sufficient to interact with the at least one salt in the vessel to produce a (p, n) reaction resulting in the generation of a neutron at the first energy level. In the example, the externally generated proton beam is directed into the vessel such that at least some protons forming the beam will interact with an atom forming a part of the at least one salt contained in the vessel to causing interaction between the externally generated proton beam and the at least one salt contained in the vessel to produce (p, n) reactions resulting in the generation of neutrons within the vessel and an absorption reaction involving the generated neutrons and Thorium within the vessel. Neutrons generated within the vessel through the (p, n) reactions caused by the externally generated proton’s interaction with the at least one salt are utilized to produce a fission reaction where the fission reaction increases. the heat content of the molten salt within the vessel. In the example, a heat exchanger is used to extract heat from the molten salt within the vessel and power is generated from the extracted heat.