公开(公告)号：US20240339235A1

公开(公告)日：2024-10-10

申请号：US18745896

申请日：2024-06-17

Applicant: Curium US LLC

Inventor： Brian Regna ,  Allan Casciola ,  Lauren Radford ,  Shaun Loveless ,  David Pipes ,  William Uhland ,  Craig Brunkhorst

IPC: G21G1/00 ,  A61K51/04 ,  C01G3/00 ,  G21G1/10 ,  G21G4/08

CPC classification number: G21G1/001 ,  A61K51/0482 ,  C01G3/003 ,  G21G1/10 ,  G21G4/08 ,  G21G2001/0094

Abstract: Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

公开(公告)号：US11986815B2

公开(公告)日：2024-05-21

申请号：US17413146

申请日：2019-12-10

Applicant: SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES ET GÉNIE S.E.C.

Inventor： Brigitte Guerin ,  Sebastien Tremblay ,  Samia Ait-Mohand ,  Aiman H. Alnahwi

IPC: B01J47/026 ,  A61B6/03 ,  A61K51/08 ,  B01J39/26 ,  G21G1/00 ,  G21G1/10

CPC classification number: B01J47/026 ,  A61K51/083 ,  B01J39/26 ,  A61B6/037 ,  G21G2001/0021 ,  G21G1/10

Abstract: The present disclosure relates processes and systems for producing and/or purifying 68Ga from an irradiated substrate of 68Zn. In some embodiments, the process rely on the use two cation-exchange chromatography columns to separate 68Ga from 68Zn and other radionuclides and metallic impurities. The process achieves a high overall yield of 68Ga and a high effective molar activity while being implementable in a time compatible with the short half-life of 68Ga. In additional embodiments, the process is implemented by an automated system.

公开(公告)号：US11887745B2

公开(公告)日：2024-01-30

申请号：US17960279

申请日：2022-10-05

Applicant: Gregory Gaehle

Inventor： Gregory Gaehle

IPC: G21G1/10 ,  H05H6/00 ,  G21K5/08 ,  G21G1/00

CPC classification number: G21G1/10 ,  G21K5/08 ,  H05H6/00 ,  G21G2001/0094

Abstract: Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area, resulting in improved specific activity while reducing the amount of target material used.

公开(公告)号：US11798700B2

公开(公告)日：2023-10-24

申请号：US17040652

申请日：2019-03-26

Applicant: TRIUMF Inc. ,  THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： Andrew Kyle Henderson Robertson ,  Hua Yang ,  Stefan Zeisler ,  Paul Schaffer

IPC: G21G1/00 ,  G21G1/10 ,  B01D5/00 ,  C01B15/047 ,  C01F17/13 ,  B01D15/18 ,  B01D15/36

CPC classification number: G21G1/001 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/363 ,  C01B15/0475 ,  C01F17/13 ,  G21G1/10 ,  G21G2001/0089 ,  G21G2001/0094

Abstract: A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.

公开(公告)号：US11783957B2

公开(公告)日：2023-10-10

申请号：US16824342

申请日：2020-03-19

Applicant: SUMITOMO HEAVY INDUSTRIES, LTD.

Inventor： Hiroyuki Uno ,  Shigeharu Ochi ,  Francisco Guerra Gomez

IPC: G21K5/08 ,  G21G1/10

CPC classification number: G21K5/08 ,  G21G1/10

Abstract: A liquid target device includes a liquid accommodation portion in which a target liquid is accommodated, a beam passage through which a charged particle beam emitted from a particle accelerator passes to reach the liquid accommodation portion, a target foil that separates the beam passage and the liquid accommodation portion from each other, and a vacuum foil that separates a vacuum region provided upstream of the beam passage and the beam passage from each other. The beam passage is provided with a first gas chamber into which a cooling gas is supplied at a position on the vacuum foil side and a second gas chamber into which a cooling gas is supplied at a position closer to the target foil side than the first gas chamber and the first gas chamber and the second gas chamber are separated from each other by an intermediate foil.

公开(公告)号：US20190221325A1

公开(公告)日：2019-07-18

申请号：US16252989

申请日：2019-01-21

Applicant: TRIUMF

Inventor： Paul SCHAFFER ,  Francois BENARD ,  Kenneth R. BUCKLEY ,  Victoire HANEMAAYER ,  Cornelia Hoehr MANUELA ,  Julius Alexander KLUG ,  Michael S. KOVACS ,  Thomas J. MORLEY ,  Thomas J. RUTH ,  John VALLIANT ,  Stefan K. ZEISLER ,  Maurice G. DODD

IPC: G21G1/00 ,  C25D13/02 ,  G21F5/14 ,  C25D13/22 ,  B22F1/00

CPC classification number: G21G1/001 ,  B22F1/0088 ,  B22F7/02 ,  B22F2998/10 ,  B22F2999/00 ,  C25D13/02 ,  C25D13/22 ,  G21F5/14 ,  G21G1/10 ,  G21G2001/0042 ,  H05H6/00 ,  B22F9/22 ,  B22F2201/013 ,  B22F3/10

Abstract: A process for producing a hardened target plate coated with a molybdenum-100 metal, comprising the steps of: (i) suspending and intermixing a refined molybdenum-100 metal powder having grain sizes of less than about 10 microns, and a binder, in a polar organic solvent; (ii) inserting into the molybdate-100 mixture, a cathode plate comprising a transition metal and an anode plate comprising conductive metal; (iii) applying a potential from about 300 V to about 1,300 V to the anode plate and cathode plate; (iv) recovering the cathode plate from the molybdate-100 mixture; and (v) sintering the cathode plate at a temperature from a range of about 1,200° C. to about 1,900° C. for a period of time from about 3 h to about 8 h.

公开(公告)号：US20190198187A1

公开(公告)日：2019-06-27

申请号：US16328171

申请日：2017-08-28

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Mukesh K. Pandey ,  Timothy R. DeGrado

IPC: G21G1/00 ,  G21G1/10 ,  G21G4/08 ,  C01G15/00 ,  C01G9/00

CPC classification number: G21G1/001 ,  A61K51/06 ,  C01G9/00 ,  C01G15/00 ,  C01P2006/44 ,  C07B59/00 ,  G21G1/10 ,  G21G4/08 ,  G21G2001/0021 ,  G21G2001/0094

Abstract: Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.

公开(公告)号：US20180102196A1

公开(公告)日：2018-04-12

申请号：US15847683

申请日：2017-12-19

Applicant: Canadian Light Source Inc.

Inventor： William DIAMOND ,  Vinay NAGARKAL ,  Mark de JONG ,  Christopher REGIER ,  Linda LIN ,  Douglas ULLRICH

IPC: G21K5/08

CPC classification number: G21K5/08 ,  G21G1/001 ,  G21G1/10 ,  G21G1/12 ,  G21G2001/0036 ,  H05G2/00

Abstract: An apparatus for producing 99Mo from a plurality of 100Mo targets through a photo-nuclear reaction on the m° Mo targets. The apparatus comprises: (i) an electron linear accelerator component; (ii) a converter component capable of receiving the electron beam and producing therefrom a shower of bremsstrahlung photons; (iii) a target irradiation component for receiving the shower of bremsstrahlung photons for irradiation of a target holder mounted and positioned therein. The target holder houses a plurality of 100Mo target discs. The apparatus additionally comprises (iv) a target holder transfer and recovery component for receiving, manipulating and conveying the target holder by remote control; (v) a first cooling system sealingly engaged with the converter component for circulation of a coolant fluid therethrough; and (vi) a second cooling system sealingly engaged with the target irradiation component for circulation of a coolant fluid therethrough.

公开(公告)号：US09922743B2

公开(公告)日：2018-03-20

申请号：US13881305

申请日：2011-10-27

Applicant: Bernard Lambert ,  Jean-Michel Geets ,  Andrea Cambriani ,  Michel Degeyter ,  Maxim Kiselev

Inventor： Bernard Lambert ,  Jean-Michel Geets ,  Andrea Cambriani ,  Michel Degeyter ,  Maxim Kiselev

IPC: G21G1/10 ,  G21G4/04 ,  H05H6/00 ,  G21G1/00

CPC classification number: G21G4/04 ,  G21G1/10 ,  G21G2001/0015 ,  H05H6/00

Abstract: The invention relates to a device (1) for producing radioisotopes by irradiating a target fluid using a particle beam (13). This device comprises an irradiation cell (7) that includes a cavity (3) for receiving the target fluid. A non-cryogenic cooling device cools the walls of the cavity (3). The cavity (3) has an inclined surface (15) downwardly delimiting the cavity (3) so as to evacuate the target fluid, which condenses on contact with the cooled walls, under gravity towards a metal foil (4) which closes off this cavity (3). The inclined surface (15) intersects the plane formed by the metal foil (4), making an acute angle (a) with said plane, so as to form with the metal foil (4) a wedge-shaped zone (18) capable of collecting, by gravity, the condensed target fluid.

公开(公告)号：US20170345523A1

公开(公告)日：2017-11-30

申请号：US15605507

申请日：2017-05-25

Applicant: Ion Beam Applications, S.A.

Inventor： Benoît Nactergal ,  Frédéric Stichelbaut

IPC: G21G1/10 ,  H05H13/00

CPC classification number: G21G1/10 ,  G21F1/12 ,  H05H7/00 ,  H05H13/005 ,  H05H2277/116

Abstract: The present disclosure relates to an isotope production apparatus. In one implementation, the apparatus may include a cyclotron for producing a particle beam, a shielding surrounding the cyclotron, and a target system within the shielding. The shielding may include a first layer having a hydrogen content of at least 100 kg/m3 and a second layer having at least 4900 kg/m3 of material having an atomic number equal to or higher than 26, and at least 29 kg/m3 of hydrogen.