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公开(公告)号：US09750719B2
公开(公告)日：2017-09-05
申请号：US14802982
申请日：2015-07-17
发明人： Paul Beswick , Robert James Gleave , Shuji Hachisu , Sadie Vile , Nicolas Bertheleme , Simon E. Ward
IPC分类号： A61K31/41 , A61K31/435 , A61K31/4439 , A61K31/5386 , C07D257/04 , C07D257/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D417/06 , C07D471/10 , C07D487/14 , C07D487/08 , C07D491/08 , C07D513/04 , C07D471/04 , C07D487/04 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/551
CPC分类号： A61K31/41 , A61K31/435 , A61K31/4439 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/551 , C07D257/04 , C07D257/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/08 , C07D513/04
摘要： The present invention relates to novel tetrazole compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial. Formula (I) wherein A is: (II) or (III) wherein A is
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公开(公告)号：US09737536B2
公开(公告)日：2017-08-22
申请号：US15163845
申请日：2016-05-25
IPC分类号： C07D471/10 , C07D487/10 , A61K31/407 , A61K31/506 , A61K31/438
CPC分类号： A61K31/506 , A61K31/407 , A61K31/438 , C07D471/10 , C07D487/10
摘要： The invention relates to spiro derivatives, to the use of said derivatives intreating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.
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公开(公告)号：US08530478B2
公开(公告)日：2013-09-10
申请号：US13054265
申请日：2009-07-15
申请人： Paul John Beswick , Alister Campbell , Andrew Peter Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
发明人： Paul John Beswick , Alister Campbell , Andrew Peter Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D213/81
摘要： The present invention relates to novel piperazine derivatives (I); to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
摘要翻译： 本发明涉及新型哌嗪衍生物（I）; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。
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公开(公告)号：US10010551B2
公开(公告)日：2018-07-03
申请号：US15646552
申请日：2017-07-11
IPC分类号： C07D471/10 , A61K31/506 , A61K31/407 , A61K31/438 , C07D487/10
CPC分类号： A61K31/506 , A61K31/407 , A61K31/438 , C07D471/10 , C07D487/10
摘要： The invention relates to spiro deriviatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.
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![Pyrazolo[1,5-A]pyrimidine-carbonyl-piperazine derivatives](/abs-image/US/2012/01/10/US08093249B2/abs.jpg.150x150.jpg)
公开(公告)号：US08093249B2
公开(公告)日：2012-01-10
申请号：US12503135
申请日：2009-07-15
申请人： Jag Paul Heer , David Norton , Simon E Ward
发明人： Jag Paul Heer , David Norton , Simon E Ward
IPC分类号： A61K31/497 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
摘要翻译： 本发明涉及新的哌嗪衍生物; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。
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公开(公告)号：US20110098335A1
公开(公告)日：2011-04-28
申请号：US12984318
申请日：2011-01-04
IPC分类号： A61K31/401 , A61P25/00
CPC分类号： A61K31/401
摘要： The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels.
摘要翻译： 本发明提供式（I）化合物，其溶剂合物，盐或前药，其可用于治疗通过调节依赖于电压门控钠通道介导的疾病和病症。
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公开(公告)号：US07855218B2
公开(公告)日：2010-12-21
申请号：US11570556
申请日：2006-10-06
IPC分类号： A61K31/454 , A61K31/40 , C07D401/02 , C07D207/00
CPC分类号： C07D487/04 , C07D207/22 , C07D211/60 , C07D401/04
摘要： Compounds of formula (I) wherein the variables are defined herein, pharmaceutical compositions thereof and methods for treatment using the same.
摘要翻译： 其中变量在本文中定义的式（I）化合物，其药物组合物和使用其的治疗方法。
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公开(公告)号：US10421716B2
公开(公告)日：2019-09-24
申请号：US15539381
申请日：2015-12-23
发明人： David MacPherson , David Witty , Gerard Giblin , Michael Williams , Donald Walker , William Kiesman , Tamera Mack
IPC分类号： C07D207/16
摘要： The invention relates to a novel process for preparing α-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
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公开(公告)号：US10231950B2
公开(公告)日：2019-03-19
申请号：US15516031
申请日：2015-10-02
发明人： Valerie Morisset
IPC分类号： A61K31/401 , C07D207/04 , C12Q1/6883
摘要： The present invention is directed to the treatment of erythromelalgia comprising administering to a subject in need thereof, a therapeutically effective amount of 5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-prolinamide or a pharmaceutically acceptable salt, solvate or prodrug thereof.
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公开(公告)号：US09376445B2
公开(公告)日：2016-06-28
申请号：US14403473
申请日：2013-05-22
IPC分类号： C07D471/10 , C07D487/10 , A61K31/407 , A61K31/438
CPC分类号： A61K31/506 , A61K31/407 , A61K31/438 , C07D471/10 , C07D487/10
摘要： The invention relates to spiro derivatives, to the use of said derivatives intreating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.
摘要翻译： 本发明涉及螺衍生物，涉及将介导由电压门控钠通道调节介导的疾病和病症的所述衍生物用于含有所述衍生物的组合物及其制备方法。
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