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    PREDICTIVE MODELS AND METHODS FOR DIAGNOSING AND ASSESSING CORONARY ARTERY DISEASE
    3.
    发明申请
    PREDICTIVE MODELS AND METHODS FOR DIAGNOSING AND ASSESSING CORONARY ARTERY DISEASE 审中-公开
    用于诊断和评估冠状动脉疾病的预测模型和方法

    公开(公告)号：US20110184712A1

    公开(公告)日：2011-07-28

    申请号：US12682579

    申请日：2008-10-10

    申请人： Steve Rosenberg ,  Susan Daniels ,  Michael R. Elashoff ,  James A. Wingrove ,  Whittemore G. Tingley ,  Amy J. Sehnert ,  Nicholas F. Paoni

    发明人： Steve Rosenberg ,  Susan Daniels ,  Michael R. Elashoff ,  James A. Wingrove ,  Whittemore G. Tingley ,  Amy J. Sehnert ,  Nicholas F. Paoni

    IPC分类号： G06G7/60

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158

    摘要： Biomarkers useful for diagnosing and assessing the extent of coronary artery disease (CAD) are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers are organized into clustered groups. The expression level of the biomarkers within a group are highly correlated to each other in normal and disease states. Expression values of genes chosen from each of two, three, four or five of the clustered gene groups, A, B, C, D, E may be used. Alternatively, expression values of genes chosen from the groups are combined into a metagene. Preferred biomarkers include S100A12, S100A8, S100A9, BCL2A1, and F5 (group A); XK, P62, and FECH (group B); TUBB2 (group C); IFNG, PDGFB, VSIG4, and TNF (group D); CSF3R, TLR5, CD46, and NCF1 (group E); S100A12, S100A9, BCL2A1, TXN and CSTA (group I); OLIG1, OLIG2, ADORA3, CLC, and SLC29A1 (group II); and CBS and ARG1 (group IV).

    摘要翻译： 提供了有助于诊断和评估冠状动脉疾病（CAD）程度的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 在优选的实施方案中，生物标志物被组织成聚集的组。 一组中生物标志物的表达水平在正常和疾病状态下彼此高度相关。 可以使用从两个，三个，四个或五个聚簇基因组A，B，C，D，E中的每一个中选择的基因的表达值。 或者，选自组中的基因的表达值被组合成元源。 优选的生物标志物包括S100A12，S100A8，S100A9，BCL2A1和F5（组A）; XK，P62和FECH（B组）; TUBB2（C组）; IFNG，PDGFB，VSIG4和TNF（D组）; CSF3R，TLR5，CD46和NCF1（组E）; S100A12，S100A9，BCL2A1，TXN和CSTA（组I）; OLIG1，OLIG2，ADORA3，CLC和SLC29A1（组II）; 和CBS和ARG1（组IV）。

    PREDICTIVE MODELS AND METHOD FOR ASSESSING AGE
    4.
    发明申请
    PREDICTIVE MODELS AND METHOD FOR ASSESSING AGE 有权
    预测模型和评估年龄的方法

    公开(公告)号：US20120036101A1

    公开(公告)日：2012-02-09

    申请号：US13264360

    申请日：2010-04-14

    申请人： Steve Rosenberg ,  Whittemore G. Tingley ,  Michael R. Elashoff ,  James A. Winrove

    发明人： Steve Rosenberg ,  Whittemore G. Tingley ,  Michael R. Elashoff ,  James A. Winrove

    IPC分类号： G06N5/04

    CPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q2600/158 ,  G06Q10/04 ,  G06Q30/02 ,  C12Q2565/501 ,  C12Q2537/165

    摘要： Biomarkers useful for diagnosing and assessing physiological age are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers include a group of biomarkers whose expression levels are highly correlated to each other. In a preferred embodiment, expression levels of CD248; CD248 and SLC 1A7; CD248 and one, two, three or four of the group consisting of CCR7, B3GAT1, VSIG4 and LR-RN3; or CD248, SLC1A7 and one, two, three or four of the group consisting of CCR7, B3GAT1, VSIG4 and LRRN3 are determined.

    摘要翻译： 提供了用于诊断和评估生理年龄的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 在优选的实施方案中，生物标志物包括其表达水平彼此高度相关的一组生物标志物。 在优选的实施方案中，CD248的表达水平; CD248和SLC 1A7; CD248和由CCR7，B3GAT1，VSIG4和LR-RN3组成的组中的一个，两个，三个或四个; 或CD248，SLC1A7以及由CCR7，B3GAT1，VSIG4和LRRN3组成的组中的一个，两个，三个或四个。

    Predictive models and method for assessing age
    7.
    发明授权
    Predictive models and method for assessing age 有权
    预测模型和评估年龄的方法

    公开(公告)号：US08825587B2

    公开(公告)日：2014-09-02

    申请号：US13264360

    申请日：2010-04-14

    申请人： Steve Rosenberg ,  Whittemore G. Tingley ,  Michael R. Elashoff ,  James A. Winrove

    发明人： Steve Rosenberg ,  Whittemore G. Tingley ,  Michael R. Elashoff ,  James A. Winrove

    IPC分类号： G06F15/18 ,  G06F17/15 ,  G06F17/16 ,  C12Q1/68 ,  G06Q10/04 ,  G06Q30/02

    CPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q2600/158 ,  G06Q10/04 ,  G06Q30/02 ,  C12Q2565/501 ,  C12Q2537/165

    摘要： Biomarkers useful for diagnosing and assessing physiological age are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers include a group of biomarkers whose expression levels are highly correlated to each other. In a preferred embodiment, expression levels of CD248; CD248 and SLC 1A7; CD248 and one, two, three or four of the group consisting of CCR7, B3GAT1, VSIG4 and LRRN3; or CD248, SLC1A7 and one, two, three or four of the group consisting of CCR7, B3GAT1, VSIG4 and LRRN3 are determined.

    摘要翻译： 提供了用于诊断和评估生理年龄的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 在优选的实施方案中，生物标志物包括其表达水平彼此高度相关的一组生物标志物。 在优选的实施方案中，CD248的表达水平; CD248和SLC 1A7; CD248和由CCR7，B3GAT1，VSIG4和LRRN3组成的组中的一个，两个，三个或四个; 或CD248，SLC1A7以及由CCR7，B3GAT1，VSIG4和LRRN3组成的组中的一个，两个，三个或四个。