METHOD FOR DOWN-REGULATING GENE EXPRESSION IN FUNGI
    1.
    发明申请
    METHOD FOR DOWN-REGULATING GENE EXPRESSION IN FUNGI 审中-公开
    在真菌中下调基因表达的方法

    公开(公告)号:US20150133523A1

    公开(公告)日:2015-05-14

    申请号:US14488493

    申请日:2014-09-17

    申请人: DEVGEN PTE LTD.

    IPC分类号: A01N57/16 C12N15/113

    摘要: The present invention concerns methods for controlling fungus infestation via dsRNA mediated gene silencing, whereby the intact fungus cell(s) are contacted with a double-stranded RNA from outside the fungal cell(s) and whereby the double-stranded RNA is taken up by the intact fungal cell(s). In one particular embodiment, the methods of the invention are used to alleviate plants from fungus pests. Alternatively, the methods are used for treating and/or preventing fungal infestation on a substrate or a subject in need of such treatment and/or prevention. Suitable fungal target genes and fragments thereof, dsRNA constructs, recombinant constructs and compositions are disclosed.

    摘要翻译: 本发明涉及通过dsRNA介导的基因沉默来控制真菌感染的方法,其中完整的真菌细胞与来自真菌细胞外的双链RNA接触,由此双链RNA被 完整的真菌细胞。 在一个具体实施方案中,本发明的方法用于减轻植物从真菌害虫中的减少。 或者,所述方法用于治疗和/或预防对需要这种治疗和/或预防的基质或受试者的真菌侵袭。 公开了合适的真菌靶基因及其片段,dsRNA构建体,重组构建体和组合物。