利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

103 条记录 (耗时 0.044 秒)

    COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY
    5.
    发明申请
    COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY 有权

    公开(公告)号：US20220125958A1

    公开(公告)日：2022-04-28

    申请号：US17488810

    申请日：2021-09-29

    申请人： Endocyte, Inc. ,  Purdue Research Foundation

    发明人： Iontcho R. VLAHOV ,  Christopher P. LEAMON ,  Philip S. LOW ,  Garth L. PARHAM ,  Quinshou CHEN

    IPC分类号： A61K51/04

    摘要： Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.

    SHIELDING AGENTS AND THEIR USE
    6.
    发明申请
    SHIELDING AGENTS AND THEIR USE 有权

    公开(公告)号：US20210323985A1

    公开(公告)日：2021-10-21

    申请号：US17277806

    申请日：2019-09-19

    申请人： ENDOCYTE, INC.

    发明人： Christopher Paul LEAMON ,  Iontcho Radoslavov VLAHOV

    IPC分类号： C07F9/38 ,  C07C275/16 ,  A61K51/04 ,  A61K31/662 ,  A61K31/17

    摘要： The present disclosure relates to compounds useful as shielding agents for PSMA therapies. The present disclosure relates to methods of treating PSMA expressing cancers with one or more radiotherapeutics agents in combination with one or more shielding agents. The present disclosure relates to methods of imaging using one or more imaging agents containing a radionuclide in combination with one or more shielding agents. The present disclosure also relates to methods of making shielding agents.

    Bivalent linkers and conjugates thereof
    8.
    发明授权
    Bivalent linkers and conjugates thereof 有权

    公开(公告)号：US10647676B2

    公开(公告)日：2020-05-12

    申请号：US16444786

    申请日：2019-06-18

    申请人： Endocyte, Inc.

    发明人： Iontcho R. Vlahov ,  Christopher P. Leamon ,  Apparao Satyam ,  Stephen J. Howard

    IPC分类号： C07D213/71 ,  C07D401/12 ,  C07D475/04 ,  A61K49/00 ,  A61K47/55 ,  A61K47/68

    摘要： This invention pertains to bivalent linkers, and the synthesis and use thereof. In particular, this invention pertains to the synthesis and use of bivalent linkers in preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates. The present invention includes divalent linkers, which are alternatively referred to as bivalent linkers, that may be used to couple, link, bond, attach, or otherwise associate two or more chemical entities. This coupling, linking, attachment, or association may be used in the formation of conjugates of such chemical entities. Those chemical entities include targeting ligands and receptor-binding ligands, such as vitamins. Those chemical entities also include drugs for treating various diseases or disease states, and imaging and diagnostic agents for diagnosing, detecting, or otherwise monitoring various diseases or disease states.