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公开(公告)号：US5349181A
公开(公告)日：1994-09-20
申请号：US98125
申请日：1993-07-26
申请人： Devinder P. Saini , Tommy J. Law
发明人： Devinder P. Saini , Tommy J. Law
CPC分类号： G01N21/7703
摘要： In a sensor assembly, an optical fiber with a sensing region is connected at one end through a fiber guide tube to a detector housing containing a sensing detector. At the other end the fiber is connected through a fiber guide tube to a light source which has a reference detector mounted laterally thereto. The sensing and reference detectors are a matched pair of the same type. The guide tube in the source has a bevelled end which reflects a portion of light from the source to the reference detector.
摘要翻译： 在传感器组件中，具有感测区域的光纤在一端通过光纤导管连接到包含传感检测器的检测器壳体。 在另一端，纤维通过纤维导管连接到具有横向安装的参考探测器的光源。 感测和参考检测器是相同类型的匹配对。 源中的引导管具有倾斜的端部，其将来自源的一部分光反射到参考检测器。
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公开(公告)号：US5405583A
公开(公告)日：1995-04-11
申请号：US22140
申请日：1993-02-25
CPC分类号： G01N21/783 , G01N33/004 , Y10T436/205831
摘要： A solid state optical sensor for CO has a sensing material which includes a molybdenum, tungsten or vanadium color forming agent; a palladium, ruthenium or osmium catalyst; and an iron, chromium or cesium reversing agent. A redox property modifier and/or an interference suppressing agent may also be included. The chemistry is contained in a polymer embedding matrix, with permeation enhancer, if required. Solubility of the chemistry in the polymer matrix is enhanced by lipophilic counterions. The matrix with embedded sensing chemistry is coated on an optical substrate to form an optical transducer.
摘要翻译： 一种用于CO的固态光学传感器具有包括钼，钨或钒成色剂的感测材料; 钯，钌或锇催化剂; 和铁，铬或铯逆转剂。 还可以包括氧化还原性质改性剂和/或干扰抑制剂。 如果需要，化学物质包含在聚合物包埋基质中，并具有渗透促进剂。 化学在聚合物基质中的溶解度通过亲脂性抗衡离子增强。 具有嵌入式感测化学的矩阵涂覆在光学基底上以形成光学传感器。
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公开(公告)号：US5302350A
公开(公告)日：1994-04-12
申请号：US9066
申请日：1993-01-26
CPC分类号： G01N21/783 , G01N33/004 , Y10T436/205831
摘要： A molybdenum salt-palladium salt solution for CO detection is made reversible by addition of ferric ion. The system is made more CO specific by adding an interference control salt which forms white or colorless precipitates with interfering species. The operational and shelf life are extended by a mixture of counterions; the acetate counterion is particularly useful.
摘要翻译： 用于CO检测的钼盐 - 钯盐溶液通过加入三价铁离子而可逆。 通过加入干扰物质形成白色或无色沉淀物的干扰控制盐，使系统更加CO特异性。 操作和保质期通过混合的反离子扩展; 乙酸盐抗衡离子特别有用。
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公开(公告)号：US5891658A
公开(公告)日：1999-04-06
申请号：US671378
申请日：1996-06-27
IPC分类号： G01N33/543 , G01N33/53 , G01N33/552
CPC分类号： G01N33/54386 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Simplicity, sensitivity and versatility of optical sensors based on competitive immunoassays using antibody-antigen reactions are achieved by solid-state, single-step reactions which permit accurate sensitive qualitative and quantitative information to be obtained without human participation. All of the chemistry-biochemistry is an inherent part of the sensor. A direct reaction occurs when the sample (antigen) is brought in contact with the sensor. The sensitivity of the competitive immunoassay optical sensor is controlled and increased by selecting a tag for the antigen or altering the attachment of a tag to an antigen so that the binding of tagged antigen to an antibody is decreased relative to the binding of untagged antigen to the antibody. The user can vary size, molecular weight and geometric configuration of the tagged antigen. This can be accomplished by selecting the proper tag or by attaching the indicator material to the antigen through a spacer or by attaching the tag directly to the antigen and attaching a compound of proper molecular weight and size elsewhere. Pretreatment of the substrate to which the antibody-bound tagged antigen is immobilized to block the surface from unwanted interferences and the use of optical isolation increases sensitivity. If the tag cannot be attached to the antigen, it is attached to the antibody. Attaching the controlled size, molecular weight tag to either the antigen or antibody permits the analysis of species not normally measureable by competitive immunoassay, thus increasing the versatility of the method.
摘要翻译： 基于使用抗体 - 抗原反应的竞争性免疫测定法的光学传感器的简单性，灵敏度和通用性通过固态单步反应实现，其允许在没有人参与的情况下获得准确的敏感性定性和定量信息。 所有的化学生物化学是传感器的固有部分。 当样品（抗原）与传感器接触时，会发生直接反应。 竞争性免疫测定光学传感器的灵敏度通过选择抗原标签或改变标签对抗原的附着来控制和增加，使得标记的抗原与抗体的结合相对于未标记的抗原与 抗体。 用户可以改变标记抗原的大小，分子量和几何构型。 这可以通过选择适当的标签或通过间隔物将指示剂材料附着到抗原上或通过将标签直接附着在抗原上并将其它地方具有合适的分子量和大小的化合物来实现。 固定有抗体结合标记的抗原的底物的预处理以阻止表面免受不想要的干扰，并且使用光学隔离增加灵敏度。 如果标签不能连接到抗原上，则其与抗体连接。 将受控大小的分子量标签附加到抗原或抗体上允许通过竞争性免疫测定通常不能测量的物种的分析，从而增加该方法的通用性。
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公开(公告)号：US5346671A
公开(公告)日：1994-09-13
申请号：US22324
申请日：1993-02-25
CPC分类号： G01N21/783 , G01N33/004 , Y10T436/205831
摘要： A molybdenum, tungsten or vanadium salt-palladium, ruthenium or osmium salt solution for CO detection is made reversible by addition of ferric, chromium (VI) or cerium (IV) ion. The system is made more CO specific by adding an interference control salt which forms white or colorless precipitates with interfering species. The operational and shelf life are extended by a mixture of counterions; the acetate counterion is particularly useful.
摘要翻译： 用于CO检测的钼，钨或钒盐 - 钯，钌或锇盐溶液通过加入三价铁，铬（VI）或铈（IV）离子而可逆。 通过加入干扰物质形成白色或无色沉淀物的干扰控制盐，使系统更加CO特异性。 操作和保质期通过混合的反离子扩展; 乙酸盐抗衡离子特别有用。
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6.发明授权Ultrasensitive single-step, solid-state competitive immunoassay sensor with interference modifier and/or gel layer 失效具有干扰调节剂和/或凝胶层的超敏感单步，固态竞争性免疫测定传感器
公开(公告)号：US5780251A
公开(公告)日：1998-07-14
申请号：US774389
申请日：1996-12-30
IPC分类号： G01N33/543 , G01N33/53 , G01N33/552
CPC分类号： G01N33/54373 , G01N33/54386 , Y10S435/808 , Y10S436/805
摘要： Simplicity, sensitivity and versatility of optical sensors based on competitive immunoassays using antibody-antigen reactions are achieved by solid-state, single-step reactions which permit accurate sensitive qualitative and quantitative information to be obtained without human participation. All of the chemistry-biochemistry is an inherent part of the sensor. A direct reaction occurs when the sample (antigen) is brought in contact with the sensor. The sensitivity of the competitive immunoassay optical sensor is controlled and increased by selecting a tag for the antigen or altering the attachment of a tag to an antigen so that the binding of tagged antigen to an antibody is decreased relative to the binding of untagged antigen to the antibody. The user can vary size, molecular weight and geometric configuration of the tagged antigen. This can be accomplished by selecting the proper tag or by attaching the indicator material to the antigen through a spacer or by attaching the tag directly to the antigen and attaching a compound of proper molecular weight and size elsewhere. Pretreatment of the substrate to which the antibody-bound tagged antigen is immobilized to block the surface from unwanted interferences and the use of optical isolation increases sensitivity. If the tag cannot be attached to the antigen, it is attached to the antibody. Attaching the controlled size, molecular weight tag to either the antigen or antibody permits the analysis of species not normally measureable by competitive immunoassay, thus increasing the versatility of the method. Background from displaced tagged antigen can be reduced, and sensitivity increased, by including an interference modifier in the tagged antigen. A gel layer on the sensor extends the ability to detect gaseous or solid species by maintaining the sensing chemistry in an internal wet environment.
摘要翻译： 基于使用抗体 - 抗原反应的竞争性免疫测定法的光学传感器的简单性，灵敏度和通用性通过固态单步反应实现，其允许在没有人参与的情况下获得准确的敏感性定性和定量信息。 所有的化学生物化学是传感器的固有部分。 当样品（抗原）与传感器接触时，会发生直接反应。 竞争性免疫测定光学传感器的灵敏度通过选择抗原标签或改变标签对抗原的附着来控制和增加，使得标记的抗原与抗体的结合相对于未标记的抗原与 抗体。 用户可以改变标记抗原的大小，分子量和几何构型。 这可以通过选择适当的标签或通过间隔物将指示剂材料附着到抗原上或通过将标签直接附着在抗原上并将其它地方具有合适的分子量和大小的化合物来实现。 固定有抗体结合标记的抗原的底物的预处理以阻止表面免受不想要的干扰，并且使用光学隔离增加灵敏度。 如果标签不能连接到抗原上，则其与抗体连接。 将受控大小的分子量标签附加到抗原或抗体上允许通过竞争性免疫测定通常不能测量的物种的分析，从而增加该方法的通用性。 通过在标记的抗原中包含干扰调节剂，可以减少来自置换的标签抗原的背景，并提高灵敏度。 传感器上的凝胶层通过将感测化学物质保持在内部湿润环境中，扩展了检测气态或固体物质的能力。
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公开(公告)号：US5737457A
公开(公告)日：1998-04-07
申请号：US587231
申请日：1996-01-16
CPC分类号： G02B6/43 , G01N21/431 , G01N21/7703 , G02B6/42
摘要： Waveguide sensors are formed on a chip package which contains at least one source and at least one detector. Simple waveguide elements are mounted on the chip. Waveguide defining elements can also be formed integrally with the chip package so that simple waveguide bodies can be inserted or removed. Various geometries of source, reference detector, and sensing detector can be produced. A liquid waveguide sensor is formed by filling a waveguide channel with a liquid reagent or reagents homogeneously dispersed in sol-gels. Sensing waveguides are made of or contain chemistries or biochemistries or are uncoated. Reference waveguides are made of or contain chemistries, biochemistries or materials which are inert to the analyte (sample) of interest. The chip geometries are such that absorption, fluorescence, and refractive index measurements can be made.
摘要翻译： 波导传感器形成在包含至少一个源和至少一个检测器的芯片封装上。 简单的波导元件安装在芯片上。 波导限定元件也可以与芯片封装一体地形成，从而可以插入或移除简单的波导体。 可以生产源，参考检测器和感测检测器的各种几何形状。 通过用均匀分散在溶胶中的液体试剂或试剂填充波导通道来形成液体波导传感器。 传感波导由化学物质或生物化学物质制成或包含或未被涂覆。 参考波导由对感兴趣的分析物（样品）是惰性的化学物质，生物化学物质或材料制成或包含。 芯片的几何形状使得可以进行吸收，荧光和折射率测量。
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公开(公告)号：US5253037A
公开(公告)日：1993-10-12
申请号：US925560
申请日：1992-08-04
CPC分类号： G01N21/552 , G01N2021/432
摘要： In a refractive index type optical sensor having a thin film metal clad on a waveguide to control leakage of light as a function of refractive index, light leakage occurs in the region where a discontinuity in refractive index occurs. A discontinuous clad with short, closely spaced segments maximizes light leakage and sensitivity over the length of the sensing region. Multiple sensing regions can be formed on a single waveguide.
摘要翻译： 在折射率型光学传感器中，具有在波导上包覆的薄膜金属以控制作为折射率的函数的光的泄漏，在发生折射率不连续的区域中发生漏光。 具有短的，紧密间隔的段的不连续包层在感测区域的长度上最大化了光泄漏和灵敏度。 可以在单个波导上形成多个感测区域。
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公开(公告)号：US5650123A
公开(公告)日：1997-07-22
申请号：US511959
申请日：1995-08-07
CPC分类号： G01N21/7703 , G01N21/431 , G02B6/42 , G02B6/43
摘要： Waveguide sensors are formed on a chip package which contains at least one source and at least one detector. Simple waveguide elements are mounted on the chip. Waveguide defining elements can also be formed integrally with the chip package so that simple waveguide bodies can be inserted or removed. Various geometries of source, reference detector, and sensing detector can be produced. A liquid waveguide sensor is formed by filling a waveguide channel with a liquid reagent.
摘要翻译： 波导传感器形成在包含至少一个源和至少一个检测器的芯片封装上。 简单的波导元件安装在芯片上。 波导限定元件也可以与芯片封装一体地形成，从而可以插入或移除简单的波导体。 可以生产源，参考检测器和感测检测器的各种几何形状。 通过用液体试剂填充波导通道形成液体波导传感器。
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