公开(公告)号：US06992215B2

公开(公告)日：2006-01-31

申请号：US10959199

申请日：2004-10-07

申请人： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara S. Slusher

发明人： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara S. Slusher

IPC分类号： C07C321/06 ,  C07C323/04 ,  C07C317/14 ,  A61K31/095

CPC分类号： C07C323/56 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.