公开(公告)号：US4082732A

公开(公告)日：1978-04-04

申请号：US600026

申请日：1975-07-29

申请人： Lawrence Burton ,  Frank Friedman

发明人： Lawrence Burton ,  Frank Friedman

IPC分类号： A61K35/14 ,  A23J1/06

CPC分类号： A61K38/1709 ,  Y10S210/905 ,  Y10S530/83

摘要： A process is provided for the isolation of a mammalian blood protein fraction or derivative thereof, herein termed the "deblocking protein fraction" or "DPF". The process comprises a series of centrifugal separations of blood fractions under conditions which maintain the integrity of the desired material as it existed in vivo.The deblocking protein fraction is a new material and it constitutes another aspect of the disclosure. isolated DPF, a protein or derivative thereof, is useful as a neoplastic tissue remission and prevention agent.

公开(公告)号：US4076701A

公开(公告)日：1978-02-28

申请号：US600027

申请日：1975-07-29

申请人： Lawrence Burton ,  Frank Friedman

发明人： Lawrence Burton ,  Frank Friedman

IPC分类号： A61K38/00 ,  C07K14/47 ,  A23J1/06

CPC分类号： C07K14/47 ,  A61K38/00 ,  Y10S530/828 ,  Y10S530/829

摘要： A process is provided for the isolation of a blood polypeptide fraction or derivatives thereof herein termed the "tumor complement fraction" or "TCF", from mammalian blood. The process comprises a series of centrifugal separations of blood fractions under conditions which maintain the integrity of the desired material as it existed in vivo.The Tumor Complement Fraction, is a new material and it constitutes another aspect of the disclosure. Isolated TCF, a natural polypeptide or derivative thereof, is useful as a neoplastic tissue remission and prevention agent.

摘要翻译： 提供了用于从哺乳动物血液分离本文称为“肿瘤补体部分”或“TCF”的血液多肽部分或其衍生物的方法。 该方法包括在保持所需材料在体内存在的完整性的条件下的血液级分的一系列离心分离。

公开(公告)号：US4196121A

公开(公告)日：1980-04-01

申请号：US880547

申请日：1978-02-23

申请人： Lawrence Burton ,  Frank Friedman

发明人： Lawrence Burton ,  Frank Friedman

IPC分类号： A23J1/06 ,  A61K35/14

CPC分类号： A61K38/1709 ,  A23J1/06 ,  Y10S530/829

摘要： A process is provided for the isolation of two protein fractions herein termed the "blocking protein fractions" or "Blocker I" and "Blocker II," from mammalian blood. The process comprises a series of centrifugal separations of blood fractions under conditions which maintain the integrity of the desired material as it existed in vivo. These blocking protein fractions are new materials and they constitute another aspect of the invention. Isolated Blocker I and Blocker II, which are natural proteins or derivatives thereof, are useful to prevent tissue implant rejection, and as standards for the determination of the tumor remission activity of other materials isolated from blood.

摘要翻译： 提供了一种从哺乳动物血液中分离本文称为“阻断蛋白质级分”或“阻断剂I”和“阻断剂II”的两种蛋白质组分的方法。 该方法包括在保持所需材料在体内存在的完整性的条件下的血液级分的一系列离心分离。 这些阻断蛋白质级分是新材料，它们构成本发明的另一方面。 作为天然蛋白质或其衍生物的分离的阻断剂I和阻断剂II可用于防止组织植入物排斥，以及用于确定从血液中分离的其它材料的肿瘤缓解活性的标准。

公开(公告)号：US4082733A

公开(公告)日：1978-04-04

申请号：US600028

申请日：1975-07-29

申请人： Lawrence Burton ,  Frank Friedman

发明人： Lawrence Burton ,  Frank Friedman

IPC分类号： A61K35/14 ,  A23J1/06

CPC分类号： A61K38/1709 ,  Y10S530/829

摘要： A process is provided for the isolation of a protein fraction herein termed the "blocking protein fraction" or "BPF", from mammalian blood. The process comprises a series of centrifugal separations of blood fractions under conditions which maintain the integrity of the desired material as it existed in vivo.The blocking protein fraction, is a new material and it constitutes another aspect of the disclosure. Isolated BPF, a natural protein or a derivative thereof, is useful to prevent tissue implant rejection, and as standard from the determination of the tumor remission activity of other materials isolated from blood.

公开(公告)号：US4199497A

公开(公告)日：1980-04-22

申请号：US880545

申请日：1978-02-23

申请人： Lawrence Burton ,  Frank Friedman

发明人： Lawrence Burton ,  Frank Friedman

IPC分类号： A23J1/06 ,  A61K35/14

CPC分类号： A23J1/06 ,  A61K38/1709 ,  Y10S530/83

摘要： A process is provided for the isolation of a mammalian blood protein fraction or derivative thereof, herein termed the "Prol A" fraction. The process comprises a series of centrifugal separations of blood fractions under conditions which maintain the integrity of the desired material as it existed in vivo.The "Prol A" fraction is a new material which constitutes another aspect of the invention. Prol A, a protein or derivative thereof, is useful as a neoplastic tissue remission and prevention agent.

摘要翻译： 提供了用于分离哺乳动物血液蛋白质级分或其衍生物的方法，这里称为“Prol A”级分。 该方法包括在保持所需材料在体内存在的完整性的条件下的血液级分的一系列离心分离。 “Prol A”级分是构成本发明另一方面的新材料。 Prol A，其蛋白质或其衍生物，可用作肿瘤组织缓解和预防剂。