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1.发明授权公开(公告)号：US09676838B2
公开(公告)日：2017-06-13
申请号：US15064846
申请日：2016-03-09
申请人： APC EUROPE S.A.
IPC分类号： C07K16/00 , C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K10/24 , A23K20/147 , A23K20/142 , A23K10/14 , A23K50/20 , A23K50/10 , A23K1/04 , A23K1/18 , A61K38/42 , A23L33/18
CPC分类号： C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K10/14 , A23K10/24 , A23K20/142 , A23K20/147 , A23K50/10 , A23K50/20 , A23L33/18 , A61K38/42
摘要： Use of a nutritional supplement for increasing the bacterial mass in the rumen of a ruminant. The nutritional supplement includes proteins with a degree of hydrolysis above 28% and has more than 23 mg α-amino nitrogen per gram of protein. The hydrolyzed proteins are preferably hemoglobin.
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2.发明授权Method for producing low-ash poultry plasma protein powder by utilizing poultry blood 有权利用家禽血液生产低灰分家禽血浆蛋白粉的方法公开(公告)号：US09578889B2
公开(公告)日：2017-02-28
申请号：US14384010
申请日：2013-03-08
发明人： Guoxiang Cheng , Guoyong Jiang , Wei Yu , Yong Pan , Jun Zhang , Daming Zhu , Minggang Liu , Kaibao Xiong
IPC分类号： A23J1/06
摘要： The present invention relates to a method for producing low-ash poultry plasma protein powder by utilizing poultry blood. Specifically, the method of the present invention comprises the steps of: mixing the poultry blood with an anticoagulant to obtain anticoagulated whole blood; centrifugally separating the anticoagulated whole blood to obtain plasma liquid; de-calcifying the plasma liquid via a precipitation reaction, ultra-filtrating the plasma liquid via a ultra-filtration membrane, emulsifying, and nano-filtrating to obtain the concentrated plasma liquid; and drying the concentrated plasma liquid to obtain the poultry plasma protein powder. The method of the present invention effectively overcomes the defect of difficult poultry blood deep processing, achieves the recycling of poultry blood resource, avoids wasting resources, and reduces environmental pollution; and the produced plasma protein powder has the advantages of high protein content, good palatability, balanced amino acid and the like.
摘要翻译： 本发明涉及利用家禽血液生产低灰分家禽血浆蛋白粉的方法。 具体地说，本发明的方法包括以下步骤：将家禽血与抗凝剂混合，得到抗凝血全血; 离心分离抗凝全血，获得血浆液; 通过沉淀反应使等离子体液体去钙化，通过超滤膜超滤等离子体液体，进行乳化和纳滤，得到浓缩的等离子体液体; 并干燥浓缩的血浆，得到家禽血浆蛋白粉。 本发明的方法有效克服了困难家禽血液深加工的缺陷，实现了家禽血液资源的循环利用，避免了资源浪费，减少了环境污染; 产生的血浆蛋白粉具有蛋白质含量高，适口性好，氨基酸平衡等优点。
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公开(公告)号：US09029079B2
公开(公告)日：2015-05-12
申请号：US13138484
申请日：2010-02-26
摘要： A method of biotechnological production of a bovine hemoderivative comprising the steps of: freshly acquired animal blood matter is first fermented in several phases, the blood fermentation product obtained is dried, the dried fermentation product is separated, which is followed by ethanol extraction of the blood fermentation product in several phases, the blood fermentation product is then subjected to vacuum inspissation with subsequent stabilization after undesirable substances have been removed. The condensed extract is processed with etheric preparation during which the condensed blood fermentation product is subjected to ether precipitation, and the precipitate, thus obtained is separated from the solution of undesirable substances soluble in ether.
摘要翻译： 一种生物技术生产牛血液净化方法，其特征在于包括以下步骤：将新鲜获得的动物血液物质首先在几个阶段发酵，将得到的血液发酵产物干燥，分离干燥的发酵产物，然后乙醇提取血液 发酵产物在几个阶段，血液发酵产物然后进行真空检查，随后在不期望的物质被去除之后进行稳定化。 浓缩的萃取液用乙醚制备物处理，冷凝血液发酵产物经过乙醚沉淀，将得到的沉淀物与可溶于乙醚的不需要的物质溶液分离。
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公开(公告)号：US5505980A
公开(公告)日：1996-04-09
申请号：US284159
申请日：1994-08-02
申请人： Youn S. Lee , Hyung S. Lee
发明人： Youn S. Lee , Hyung S. Lee
摘要： Powdered deer blood, preferably that of a stag, can be produced by mixing deer blood and ethanol, freezing the mixture of deer blood and ethanol to form a frozen mixture, freeze-drying the frozen mixture to form a freeze-dried mixture, heating the freeze-dried mixture, reducing the temperature of the heated mixture to form a dried product having a red-brown color; and then grinding the dried product to a powder.
摘要翻译： 可以通过混合鹿血和乙醇，冷冻鹿血和乙醇的混合物形成冷冻混合物，冷冻干燥冷冻混合物以形成冷冻干燥混合物，加热 冷冻干燥的混合物，降低加热的混合物的温度以形成具有红棕色的干燥产品; 然后将干燥的产品研磨成粉末。
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公开(公告)号：US5151500A
公开(公告)日：1992-09-29
申请号：US469557
申请日：1990-03-29
CPC分类号： A23J1/06 , A23L13/424
摘要： A substantially heme-free blood protein product is produced by adding an acid to a blood cell suspension to a low pH to disrupt erythrocytes present in the suspension thereby releasing hemoglobin, and to cleave off the heme moiety from the major proportion of the hemoglobin. The released heme forms a precipitate which is removed by centrifugation. Heme moieties remaining in the blood protein solution are degraded by treatment with an oxidizing agent, e.g. hydrogen peroxide. The product has a content of sulfur-containing amino acids which corresponds to the content thereof in natural hemoglobin, as well as foaming and emulsifying properties corresponding to naural hemoglobin. The product has a high lysine content and may be used to enrich the protein content of edible products, e.g. cereals, or to replace part of the meat in meat products. An edible product containing up to about 25% by weight of blood plasma mixed with the product is also disclosed. The product is also useful as a foaming agent, emulsifying agent or additive in chemical industrial products.
摘要翻译： PCT No.PCT / DK88 / 00127 Sec。 371 1990年3月29日第 102（e）1990年3月29日PCT PCT。 出版物WO89 / 0081600 日期：1989年2月9日。通过向血细胞悬浮液中加入酸至低pH以破坏悬浮液中存在的红细胞从而释放出血红蛋白，从而将血红素部分从 主要比例的血红蛋白。 释放的血红素形成通过离心除去的沉淀物。 残留在血液蛋白溶液中的血红素部分通过用氧化剂，例如， 过氧化氢。 该产品具有对应于天然血红蛋白含量的含硫氨基酸含量，以及对应于天然血红蛋白的发泡和乳化性能。 该产品具有高赖氨酸含量，可用于富集食用产品的蛋白质含量，例如， 谷物，或替代肉制品中的部分肉类。 还公开了含有高达约25重量％与产品混合的血浆的可食用产品。 该产品还可用作化学工业产品中的发泡剂，乳化剂或添加剂。
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公开(公告)号：US5145706A
公开(公告)日：1992-09-08
申请号：US676303
申请日：1991-03-28
申请人： Takashi Hagi , Kouichi Misawa , Shuji Saito , Yuji Sakamoto , Noriaki Kadota , Yoshiro Toda , Nagataka Yamazaki
发明人： Takashi Hagi , Kouichi Misawa , Shuji Saito , Yuji Sakamoto , Noriaki Kadota , Yoshiro Toda , Nagataka Yamazaki
CPC分类号： A23J3/12 , A23J1/06 , A23L13/424 , A23L5/273
摘要： The present invention relates to a method for preparation of plasma powder characterized by catalytic treatment of plasma with colloidal silica and subsequent powdering of the plasma. The plasma powder thus obtained by the present invention is substantially free of malodorous substances.
摘要翻译： 本发明涉及一种用于制备等离子体粉末的方法，其特征在于用胶体二氧化硅催化处理等离子体并随后粉化等离子体。 由本发明得到的等离子体粉末基本上不含恶臭物质。
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公开(公告)号：US4543210A
公开(公告)日：1985-09-24
申请号：US658081
申请日：1984-10-04
申请人： Gautam Mitra , Paul K. Ng
发明人： Gautam Mitra , Paul K. Ng
IPC分类号： C07K14/745 , A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , A61K38/43 , C07K14/435 , C07K14/755 , A23J1/06
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83
摘要： There is disclosed an improved process for producing high purity antihemophilic factor concentrate from an antihemophilic factor-containing dispersion or solution isolated from blood plasma or a blood plasma fraction, wherein the improvement is in carrying-out two consecutive precipitations using a combination of precipitants in each precipitation, first a combination of 1-4% by weight, based on weight of solution, of polyethylene glycol and 0.1-0.2 ml of 1-3%, based on weight of suspension, aluminum hydroxide suspension per gram of protein in the starting dispersion or solution, followed by a combination of added polyethylene glycol to provide a final concentration of 9-13% by weight, based on weight of the resulting solution, and 10-20% by weight of glycine, based on weight of the polyethylene glycol solution, and 10-20% by weight, based on weight of the polyethylene glycol solution, of sodium chloride.
摘要翻译： 公开了一种用于从分离自血浆或血浆级分的抗血友病因子分散体或溶液中产生高纯度抗血友病因子浓缩物的改进方法，其中改进是使用各自中的沉淀剂的组合进行两次连续的沉淀 沉淀，首先将1-4重量％的组合，基于溶液的重量，聚乙二醇和0.1-0.2ml的1-3％，基于悬浮液的重量，在起始分散体中每克蛋白质的氢氧化铝悬浮液 或溶液，随后加入的聚乙二醇的组合，以得到的溶液的重量为基准提供9-13重量％的终浓度，和基于聚乙二醇溶液重量的10-20重量％甘氨酸 ，10-20重量％，基于聚乙二醇溶液的重量计，氯化钠。
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公开(公告)号：US4518525A
公开(公告)日：1985-05-21
申请号：US552032
申请日：1983-11-03
申请人： Karin Autio , Martti Kiesvaara , Yrjo Malkki
发明人： Karin Autio , Martti Kiesvaara , Yrjo Malkki
IPC分类号： C12Q1/56 , A23J1/06 , A61K31/40 , A61K35/18 , A61K38/00 , A61K38/16 , C07D487/00 , C07K14/805 , C07C103/52 , A61K37/02 , C07G7/00
CPC分类号： A61K31/40 , A23J1/06 , C07K14/805 , Y10S530/829
摘要： The invention relates to a method of dividing blood hemoglobin into heme and globin by suspending blood cells, separated from blood, in an acid aqueous solution, by precipitating the heme by means of carboxymethyl cellulose, and by separating the precipitated heme-CMC complex out from the aqueous solution of globin. The obtained heme-CMC complex can be used as such as raw material for the preparation of medicinal iron supplements, and the globin fraction can be used as an additive in fodder or food.
摘要翻译： PCT No.PCT / FI83 / 00022 Sec。 371日期1983年11月3日 102（e）1983年11月3日日期PCT提交1983年3月11日PCT公布。 出版物WO83 / 03198 日本1983年9月29日。本发明涉及一种通过在酸性水溶液中悬浮血液分离血液，通过羧甲基纤维素沉淀血红素而将血红蛋白分成血红素和球蛋白的方法， 从珠脑蛋白水溶液中沉淀出血红素-CM复合物。 所得到的血红素-CM复合物可以用作制备药用铁补充剂的原料，并且珠蛋白部分可以用作饲料或食物中的添加剂。
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9.发明授权Precipitation of proteins from salt-containing proteinaceous fluids employing a desalting treatment, and use thereof in selective plasmapheresis 失效使用脱盐处理从含盐蛋白质液体中沉淀蛋白质，以及其在选择性血浆置换中的应用
公开(公告)号：US4486282A
公开(公告)日：1984-12-04
申请号：US468251
申请日：1983-02-22
申请人： Milan Bier
发明人： Milan Bier
IPC分类号： A23C9/144 , A23J1/06 , A23J1/20 , A61M1/34 , C07K1/30 , C07K1/36 , C07K14/76 , C07K16/06 , B01D13/02 , B01D13/00
CPC分类号： B01D61/44 , A23C9/144 , A23J1/06 , A23J1/205 , A61M1/3472 , A61M1/3482 , A61M1/3486 , B01D61/46 , C07K1/30 , C07K14/76 , C07K16/065 , A23V2002/00 , B01D2311/04 , B01D2311/2642
摘要： Total or fractional precipitation of proteins from salt-containing proteinaceous solution or suspension mixtures is induced or enhanced by subjecting the proteinaceous mixture to a desalting treatment, for example, by electrodialysis. In one aspect of the invention, the desalting treatment is used in conjunction with the addition of heavy metal ions to the proteinaceous mixture to provide a synergistic effect on the precipitation of the protein fraction. In another aspect of the invention, the desalting treatment, either with or without the heavy metal ion addition, is employed as an integral part of a selective plasmapheresis procedure for the removal or recovery of one or more selected plasma proteins from blood plasma.
摘要翻译： 通过例如通过电渗析对蛋白质混合物进行脱盐处理，诱导或增强来自含盐蛋白质溶液或悬浮混合物的蛋白质的总分或分数沉淀。 在本发明的一个方面，脱盐处理与向蛋白质混合物中加入重金属离子一起使用以对蛋白质级分的沉淀提供协同效应。 在本发明的另一方面，使用或不加入重金属离子添加剂的脱盐处理作为用于从血浆中去除或回收一种或多种选择的血浆蛋白质的选择性血浆置换方法的组成部分。
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公开(公告)号：US4426323A
公开(公告)日：1984-01-17
申请号：US271069
申请日：1981-06-08
申请人： Surendar Jain
发明人： Surendar Jain
IPC分类号： A23C9/144 , A23J1/00 , A23J1/18 , A61M1/34 , C07K1/14 , C07K14/195 , C12P21/00 , A23J1/06 , C07G7/00
CPC分类号： B01D61/422 , A23C9/144 , A23J1/00 , A61M1/3482 , A61M1/3486 , B01D2311/04 , Y10S435/811
摘要： A process is described for the selective recovery and/or concentration of a protein or a class of proteins from fermentation broth employing a combination of desalting and pH adjustment thereby causing the initial precipitation of unwanted proteins, again subjecting the resulting supernatant to another set of pH adjustment and desalting to cause the protein of interest to precipitate thereby obtaining a highly enriched fraction of the selected protein. Such a process will find use in the specific recovery of genetically engineered proteins from fermentation broths, e.g. interferon, insulin, growth hormone, etc.
摘要翻译： 描述了使用脱盐和pH调节的组合从发酵液中选择性回收和/或浓缩蛋白质或一类蛋白质的过程，从而引起不想要的蛋白质的初始沉淀，再次将得到的上清液再次进行一组pH 调节和脱盐以使感兴趣的蛋白质沉淀，从而获得所选蛋白质的高度富集部分。 这种方法将用于从发酵液中的遗传工程改造的蛋白质的具体回收，例如， 干扰素，胰岛素，生长激素等
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