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    Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof
    4.
    发明授权
    Irreversible HIV protease inhibitors, compositions containing same and process for the preparation thereof 失效
    不可逆的HIV蛋白酶抑制剂，含有它们的组合物及其制备方法

    公开(公告)号：US5679687A

    公开(公告)日：1997-10-21

    申请号：US659794

    申请日：1996-06-06

    申请人： Nakyen Choy ,  Hoil Choi ,  Chi-Hyo Park ,  Young-Chan Son ,  Chang-Sun Lee ,  Heungsik Yoon ,  Sung-Chun Kim ,  Jong-Sung Koh ,  Chung-Ryeol Kim

    发明人： Nakyen Choy ,  Hoil Choi ,  Chi-Hyo Park ,  Young-Chan Son ,  Chang-Sun Lee ,  Heungsik Yoon ,  Sung-Chun Kim ,  Jong-Sung Koh ,  Chung-Ryeol Kim

    IPC分类号： A61K38/00 ,  C07K5/078 ,  A61K31/47 ,  A61K31/335 ,  C07D217/14 ,  C07D217/16

    CPC分类号： C07K5/06139 ,  A61K38/00

    摘要： The present invention relates to novel compounds of formula (I) which have inhibitory activity against human immunodeficiency virus ("HIV") protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group; R.sup.2 is an amino acid residue or a C.sub.1-8 alkyl group substituted with a C.sub.1-4 alkylsulfonyl group; R.sup.3 is a C.sub.1-4 alkyl group optionally substituted with an aromatic group; R.sup.4 is hydrogen or a C.sub.1-4 alkyl group; R.sup.5 is an aromatic group, a C.sub.1-10 alkyl group or a C.sub.1-4 alkyl groups optionally substituted with an aromatic group; and n is 1 or 2.

    摘要翻译： 本发明涉及对人体免疫缺陷病毒（“HIV”）蛋白酶具有抑制活性的新型式（I）化合物，其制备方法，以及用于通过HIV感染预防或治疗AIDS的组合物，其包含上述化合物作为 有效成分。 （I）其中：R1是芳基，含氮芳香基，任选被芳基或含氮芳基取代的C1-4烷基，任选被芳族取代的C 1-4烷氧基 基团或含氮芳族基团; R2是被C1-4烷基磺酰基取代的氨基酸残基或C1-8烷基; R3是任选被芳基取代的C 1-4烷基; R4是氢或C1-4烷基; R5是芳基，C1-10烷基或任选被芳基取代的C 1-4烷基; n为1或2。

    Novel composition for the transdermal administration of drugs
    5.
    发明申请
    Novel composition for the transdermal administration of drugs 审中-公开
    用于透皮给药的新型组合物

    公开(公告)号：US20010023261A1

    公开(公告)日：2001-09-20

    申请号：US09746448

    申请日：2000-12-12

    申请人： LG Chemical Limited.

    发明人： Je-Phil Ryoo ,  Mi-Suk Choi ,  Jong-Kun Choi

    IPC分类号： A61K047/10

    CPC分类号： A61K31/569 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/568 ,  A61K31/575 ,  A61K47/10 ,  A61K47/26

    摘要： A composition for the transdermal administration of a drug, comprising: 0.05 to 50 wt % of the drug based on the total weight of the composition; 1 to 30 wt % of an absorption promoter consisting of a diethylene glycol ether and a sorbitan ester in a weight ratio ranging from 1:4 to 4:1, based on the total weight of the composition; and a pharmaceutically acceptable adhesive matrix.

    摘要翻译： 一种用于透皮给药的组合物，其包含：基于组合物总重量的0.05至50重量％的药物; 1至30重量％的由二甘醇醚和脱水山梨醇酯组成的吸收促进剂，其重量比为1:4至4:1，基于组合物的总重量; 和药学上可接受的粘合剂基质。

    Process for producing thermoplastic resins having high impact strength
    6.
    发明授权
    Process for producing thermoplastic resins having high impact strength 失效
    具有高冲击强度的热塑性树脂的制造方法

    公开(公告)号：US6080815A

    公开(公告)日：2000-06-27

    申请号：US91254

    申请日：1998-06-10

    申请人： Chang-Hong Lee ,  Young-Min Kim ,  Jin-Nyoung Yoo

    发明人： Chang-Hong Lee ,  Young-Min Kim ,  Jin-Nyoung Yoo

    IPC分类号： C08F279/00 ,  C08F279/04

    CPC分类号： C08F279/04

    摘要： The present invention relates to a process for producing a thermoplastic resin having high impact strength and good surface gloss, which comprises graft copolymerizing at least a vinyl cyanide compound and at least an aromatic vinyl compound for a short period of less than about 3 hours in the presence of rubber latex having high gel content. The rubber latex can be a mixture of two or more rubber latices having different particle size. The graft copolymer has the characteristics such that the degree of the inner occlusion into the resin is decreased and the degree of surface grafting is increased. Thereby, the resulted thermoplastic resin has a very high impact strength and good surface gloss, and the processability is greatly improved. In addition, when the graft copolymer is polymerized the level of coagulum formation is greatly decreased.

    摘要翻译： PCT No.PCT / KR97 / 00213 Sec。 371日期：1998年6月10日 102（e）日期1998年6月10日PCT 1997年11月4日PCT PCT。 WO98 / 20057 PCT公开号 日期1998年5月14日本发明涉及一种具有高冲击强度和良好表面光泽度的热塑性树脂的制造方法，该方法包括至少将乙烯基氰化合物和至少一种芳香族乙烯基化合物接枝至少于约 在具有高凝胶含量的橡胶胶乳存在下3小时。 橡胶胶乳可以是两种或更多种具有不同粒度的胶乳的混合物。 接枝共聚物具有这样的特性，使得内部阻塞到树脂中的程度降低，并且表面接枝的程度增加。 因此，所得到的热塑性树脂具有非常高的冲击强度和良好的表面光泽度，并且加工性大大提高。 此外，当接枝共聚物聚合时，凝结物形成的水平大大降低。