公开(公告)号：US20110120215A1

公开(公告)日：2011-05-26

申请号：US12714587

申请日：2010-03-01

Applicant: Jose Castro ,  Yu Sheng Zhang ,  Luke Lee

Inventor： Jose Castro ,  Yu Sheng Zhang ,  Luke Lee

IPC: G01N13/04 ,  B65B3/12

CPC classification number: G01N13/04

Abstract: Transdermal diffusion cell testing vessel includes a container defining a chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. The vessel is used for conducting transdermal diffusion cell testing in combination with a solution source fluidly coupled to each vessel, a waste receptacle fluidly coupled to each vessel, a syringe pump fluidly coupled to a respective vessel, and a sample collector fluidly coupled to the syringe pump(s).

Abstract translation: 透皮扩散细胞测试容器包括限定具有开口的容器的容器，皮肤被放置在所述开口上，以及壳体，其部分地围绕容器的一部分设置并且与所述容器的一部分间隔开，以在其间限定隔室。 该室保留盐水溶液并且不与水循环通过的隔室流动连通。 该容器包括单独的入口端口和出口端口，每个入口端口和出口端口包括与腔室或隔间连通的导管。 腔室的出口相对于容器的水平上表面向下倾斜，与被测试的皮肤相对置。 该容器用于与流体耦合到每个容器的溶液源，流体耦合到每个容器的废液容器，流体耦合到相应容器的注射泵以及流体耦合到注射器的样品收集器结合进行透皮扩散池测试 泵（s）。

公开(公告)号：US20070292309A1

公开(公告)日：2007-12-20

申请号：US11453634

申请日：2006-06-15

Applicant: Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

Inventor： Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

IPC: G01N35/00

CPC classification number: G01N35/025 ,  G01N2035/0453

Abstract: Pharmaceutical product release rate testing device includes a base, at least one carousel member rotatably mounted on the base, each carousel member including a plurality of test tube pockets each adapted to receive a test tube fillable with test media, and a dipping mechanism for dipping samples to be tested into the test tubes when present in the pockets and filled with test media. A rinsing/filling mechanism is provided to rinse or fill test tubes in one set of pockets while test tubes in another set of pockets are involved in the dipping process via the dipping mechanism. The carousel member is temperature-controlled such that all of the test tubes when present in the pockets are at substantially the same temperature for critical stages of the testing process. Methods for conducting pharmaceutical product release rate testing using the device are also disclosed.

Abstract translation: 药品释放速率测试装置包括底座，至少一个可旋转地安装在基座上的转盘构件，每个回转构件包括多个试管口袋，每个试管口适于容纳可由测试介质填充的试管，以及用于浸渍样品的浸渍机构 当存在于口袋中并充满测试介质时，要被测试进入试管。 提供冲洗/填充机构以在一组袋中冲洗或填充试管，而另一组袋中的试管经由浸渍机构涉及浸渍过程。 转盘构件是温度控制的，使得当存在于口袋中的所有试管在测试过程的关键阶段处于基本相同的温度。 还公开了使用该装置进行药物产品释放速率测试的方法。

公开(公告)号：US20070101533A1

公开(公告)日：2007-05-10

申请号：US11267687

申请日：2005-11-04

Applicant: Luke Lee ,  Yu Zhang

Inventor： Luke Lee ,  Yu Zhang

IPC: B08B9/04

CPC classification number: B08B9/087

Abstract: Brush head for cleaning a vessel and use in an automatic dissolution vessel cleaning apparatus which includes a rotatable shaft defining a through passage, an upper end of which is operatively connected to a vacuum source, an inflow housing having at least one channel through which cleaning fluid is pumped and to which the shaft is rotatably mounted, and a brush assembly mounted on the shaft below the housing such that a lower end of the passage is situated below the brush assembly. In use, when the brush head is inserted into the vessel, cleaning fluid is directed through the channel(s) into the vessel while the shaft rotates causing the brush assembly to rotate and clean an inner wall of the vessel with fluid in the vessel being drawn into the passage via its lower end upon coupling of its upper end to the vacuum source.

Abstract translation: 用于清洁容器并用于自动溶解容器清洁装置的刷头，其包括限定穿过通道的可旋转轴，所述可旋转轴的上端可操作地连接到真空源，流入壳体具有至少一个通道，清洁流体 被泵送并且轴可旋转地安装到所述轴上，以及刷组件，其安装在壳体下方的轴上，使得通道的下端位于刷组件下方。 在使用时，当刷头插入容器中时，清洁流体通过通道进入容器，同时轴旋转使得刷组件旋转并且清洁容器内壁，容器内的流体是 在其上端与真空源联接时通过其下端被吸入通道。

公开(公告)号：US08322193B2

公开(公告)日：2012-12-04

申请号：US12714587

申请日：2010-03-01

Applicant: Jose Castro ,  Yu Sheng Zhang ,  Luke Lee

Inventor： Jose Castro ,  Yu Sheng Zhang ,  Luke Lee

IPC: G01N15/08

CPC classification number: G01N13/04

Abstract: Transdermal diffusion cell testing vessel includes a container defining a chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. The vessel is used for conducting transdermal diffusion cell testing in combination with a solution source fluidly coupled to each vessel, a waste receptacle fluidly coupled to each vessel, a syringe pump fluidly coupled to a respective vessel, and a sample collector fluidly coupled to the syringe pump(s).

Abstract translation: 透皮扩散细胞测试容器包括限定具有开口的容器的容器，皮肤被放置在所述开口上，以及壳体，其部分地围绕容器的一部分设置并且与所述容器的一部分间隔开，以在其间限定隔室。 该室保留盐水溶液并且不与水循环通过的隔室流动连通。 该容器包括单独的入口端口和出口端口，每个入口端口和出口端口包括与腔室或隔间连通的导管。 腔室的出口相对于容器的水平上表面向下倾斜，与被测试的皮肤相对置。 该容器用于与流体耦合到每个容器的溶液源，流体耦合到每个容器的废液容器，流体耦合到相应容器的注射泵以及流体耦合到注射器的样品收集器结合进行透皮扩散池测试 泵（s）。

公开(公告)号：US20110120214A1

公开(公告)日：2011-05-26

申请号：US12623763

申请日：2009-11-23

Applicant: Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

Inventor： Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

IPC: G01N13/04

CPC classification number: G01N13/04

Abstract: Vessel for transdermal diffusion cell testing includes a container defining an interior chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is arranged above the inlet port of the chamber, proximate the opening of the chamber, and is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. Tilting of the vessel prior to or during introduction of solution prevents air bubbles from remaining between the skin and the solution.

Abstract translation: 用于透皮扩散细胞测试的容器包括限定内部腔室的容器，所述内部腔室具有放置皮肤的开口，以及部分地围绕容器的一部分设置并且与所述容器的一部分间隔开以在其间限定隔室的壳体。 该室保留盐水溶液并且不与水循环通过的隔室流动连通。 该容器包括单独的入口端口和出口端口，每个入口端口和出口端口包括与腔室或隔间连通的导管。 腔室的出口设置在腔室的入口附近，靠近腔室的开口，并且相对于容器的水平上表面向下倾斜，与被测试的皮肤相对置。 在引入溶液之前或期间，容器的倾斜防止气泡残留在皮肤和溶液之间。

公开(公告)号：US07585465B2

公开(公告)日：2009-09-08

申请号：US11453634

申请日：2006-06-15

Applicant: Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

Inventor： Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

IPC: G01N33/48 ,  B01F9/08 ,  B01F15/06

CPC classification number: G01N35/025 ,  G01N2035/0453

Abstract: Pharmaceutical product release rate testing device includes a base, at least one carousel member rotatably mounted on the base, each carousel member including a plurality of test tube pockets each adapted to receive a test tube fillable with test media, and a dipping mechanism for dipping samples to be tested into the test tubes when present in the pockets and filled with test media. A rinsing/filling mechanism is provided to rinse or fill test tubes in one set of pockets while test tubes in another set of pockets are involved in the dipping process via the dipping mechanism. The carousel member is temperature-controlled such that all of the test tubes when present in the pockets are at substantially the same temperature for critical stages of the testing process. Methods for conducting pharmaceutical product release rate testing using the device are also disclosed.

Abstract translation: 药品释放速率测试装置包括底座，至少一个可旋转地安装在基座上的转盘构件，每个回转构件包括多个试管口袋，每个试管口适于容纳可由测试介质填充的试管，以及用于浸渍样品的浸渍机构 当存在于口袋中并充满测试介质时，要被测试进入试管。 提供冲洗/填充机构以在一组袋中冲洗或填充试管，而另一组袋中的试管经由浸渍机构涉及浸渍过程。 转盘构件是温度控制的，使得当存在于口袋中的所有试管在测试过程的关键阶段处于基本相同的温度。 还公开了使用该装置进行药物产品释放速率测试的方法。