公开(公告)号：US20160139020A1

公开(公告)日：2016-05-19

申请号：US14891465

申请日：2013-05-16

Applicant: L'OREAL

Inventor： Alexandre Nicolas ,  Sébastien Gregoire ,  Christophe Provin ,  Christophe Hadjur ,  Teruo Fujii

IPC: G01N13/00 ,  G01N27/403 ,  G01N27/07 ,  G01N21/84

CPC classification number: G01N13/00 ,  G01N13/04 ,  G01N15/082 ,  G01N21/84 ,  G01N27/07 ,  G01N27/403 ,  G01N2013/003

Abstract: The invention relates to an installation (1) for determining the diffusion profile of at least one molecule through skin, comprising: a microfluidic chip (4) comprising: a donor compartment (10) intended to contain a test solution comprising the or each molecule; a receptor compartment (12) intended to contain a receptor solution; and a membrane (14) with skin-mimetic barrier properties arranged between the donor compartment (10) and the receptor compartment (12) so that the test solution diffuses through the membrane (14) from the donor compartment (10) into the receptor compartment (12); and an analyzer (8) for measuring a physical parameter of the solution contained in the receptor compartment (12) as the test solution diffuses through the membrane (14), and said analyzer (8) being configured for measuring the physical parameter in the receptor compartment (12), the analyzer (8) being further configured for calculating the diffusion profile of the or each molecule through skin from the measured physical parameter.

Abstract translation: 本发明涉及一种用于确定通过皮肤的至少一种分子的扩散分布的装置（1），其包括：微流体芯片（4），包括：供体隔室（10），用于容纳包含所述或每个分子的测试溶液; 旨在含有受体溶液的受体隔室（12）; 以及膜（14），其具有布置在供体室（10）和受体隔室（12）之间的皮肤模拟阻挡性质，使得测试溶液通过膜（14）从供体隔室（10）扩散到受体隔室 （12）; 以及分析器（8），用于当所述测试溶液通过所述膜（14）扩散时，测量包含在所述受体室（12）中的溶液的物理参数，并且所述分析器（8）被配置为测量所述受体中的物理参数 隔室（12），分析器（8）还被配置为从测量的物理参数计算皮肤或每个分子的扩散分布。

公开(公告)号：US08628731B2

公开(公告)日：2014-01-14

申请号：US13299277

申请日：2011-11-17

Applicant: Eric Donsky ,  Benjamin Sullivan

Inventor： Eric Donsky ,  Benjamin Sullivan

IPC: G01N3/00 ,  G01N33/48

CPC classification number: G01N13/04 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/165 ,  C12Q1/00 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/77 ,  G01N33/487 ,  G01N33/68 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2021/7786 ,  G01N2201/06113 ,  Y10T436/24

Abstract: A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

Abstract translation: 一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。 被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。 样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积并将等分试样体积的样品流体转移到样品区域。

公开(公告)号：US08596110B2

公开(公告)日：2013-12-03

申请号：US13047566

申请日：2011-03-14

Applicant: Faizur Rahman

Inventor： Faizur Rahman

IPC: G01N15/08

CPC classification number: G01N13/04 ,  B01D61/12 ,  B01D63/087 ,  B01D65/102 ,  B01D2313/025 ,  B01D2313/18 ,  B01D2313/26 ,  G01N15/0806

Abstract: The device for testing reverse osmosis membranes provides for the quick and efficient testing of the transport properties of reverse osmosis membranes at a fixed pressure over a fixed period of time. The device includes a first chamber adapted for receiving a volume of de-ionized water and a second chamber adapted for receiving a volume of brine. In use, a reverse osmosis membrane to be tested is clamped between the first and second chambers and a pressurized inert gas, such as gaseous nitrogen, is injected into the second chamber at known pressure to initiate reverse osmosis transport. The transport is carried out at the known pressure for a fixed period of time, after which the concentration of brine volume of water in the first chamber is measured.

Abstract translation: 用于测试反渗透膜的装置能够在固定的时间内以固定的压力快速有效地测试反渗透膜的输送性能。 该装置包括适于接收一定体积的去离子水的第一室和适于容纳一定体积盐水的第二室。 在使用中，要测试的反渗透膜被夹在第一和第二室之间，并且在已知压力下将加压惰性气体（例如气态氮）注入第二室以引发反渗透运输。 运输在已知压力下进行一段固定的时间，之后测量第一个室中的水的盐水体积浓度。

公开(公告)号：US08322193B2

公开(公告)日：2012-12-04

申请号：US12714587

申请日：2010-03-01

Applicant: Jose Castro ,  Yu Sheng Zhang ,  Luke Lee

Inventor： Jose Castro ,  Yu Sheng Zhang ,  Luke Lee

IPC: G01N15/08

CPC classification number: G01N13/04

Abstract: Transdermal diffusion cell testing vessel includes a container defining a chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. The vessel is used for conducting transdermal diffusion cell testing in combination with a solution source fluidly coupled to each vessel, a waste receptacle fluidly coupled to each vessel, a syringe pump fluidly coupled to a respective vessel, and a sample collector fluidly coupled to the syringe pump(s).

Abstract translation: 透皮扩散细胞测试容器包括限定具有开口的容器的容器，皮肤被放置在所述开口上，以及壳体，其部分地围绕容器的一部分设置并且与所述容器的一部分间隔开，以在其间限定隔室。 该室保留盐水溶液并且不与水循环通过的隔室流动连通。 该容器包括单独的入口端口和出口端口，每个入口端口和出口端口包括与腔室或隔间连通的导管。 腔室的出口相对于容器的水平上表面向下倾斜，与被测试的皮肤相对置。 该容器用于与流体耦合到每个容器的溶液源，流体耦合到每个容器的废液容器，流体耦合到相应容器的注射泵以及流体耦合到注射器的样品收集器结合进行透皮扩散池测试 泵（s）。

公开(公告)号：US20120060588A1

公开(公告)日：2012-03-15

申请号：US13229358

申请日：2011-09-09

Applicant: Charles Wang Wai NG

Inventor： Charles Wang Wai NG

IPC: G01N33/24

CPC classification number: G01N13/04 ,  G01N33/24 ,  G01N2203/0025

Abstract: Described herein are systems, apparatuses and methods for the design and use of a suction-controlled box for the measurement of stress-dependent soil and water characteristics, shear strength, volume changes and consolidation characteristics from a single unsaturated soil specimen. The suction-controlled box can include a suction control part and a mechanical loading part, which can apply various suctions and mechanical loadings to test a specimen for a full range of suctions. The suction-controlled box can also include a helical water compartment that can flush diffused air bubbles.

Abstract translation: 本文描述了用于设计和使用用于测量来自单个不饱和土壤样品的应力依赖性土壤和水特性，剪切强度，体积变化和固结特性的抽吸控制箱的系统，装置和方法。 抽吸控制箱可以包括抽吸控制部分和机械装载部分，其可以应用各种吸附和机械负载来测试样品以获得全范围的吸入。 抽吸控制箱还可以包括能够冲洗扩散气泡的螺旋水舱。

公开(公告)号：US20110120214A1

公开(公告)日：2011-05-26

申请号：US12623763

申请日：2009-11-23

Applicant: Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

Inventor： Luke Lee ,  Yu Sheng Zhang ,  Jose Castro

IPC: G01N13/04

CPC classification number: G01N13/04

Abstract: Vessel for transdermal diffusion cell testing includes a container defining an interior chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is arranged above the inlet port of the chamber, proximate the opening of the chamber, and is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. Tilting of the vessel prior to or during introduction of solution prevents air bubbles from remaining between the skin and the solution.

Abstract translation: 用于透皮扩散细胞测试的容器包括限定内部腔室的容器，所述内部腔室具有放置皮肤的开口，以及部分地围绕容器的一部分设置并且与所述容器的一部分间隔开以在其间限定隔室的壳体。 该室保留盐水溶液并且不与水循环通过的隔室流动连通。 该容器包括单独的入口端口和出口端口，每个入口端口和出口端口包括与腔室或隔间连通的导管。 腔室的出口设置在腔室的入口附近，靠近腔室的开口，并且相对于容器的水平上表面向下倾斜，与被测试的皮肤相对置。 在引入溶液之前或期间，容器的倾斜防止气泡残留在皮肤和溶液之间。

公开(公告)号：US07734349B2

公开(公告)日：2010-06-08

申请号：US11779403

申请日：2007-07-18

Applicant: Allan Charles Shuros ,  Eric A. Mokelke ,  Michael John Kane ,  Jihong Qu

Inventor： Allan Charles Shuros ,  Eric A. Mokelke ,  Michael John Kane ,  Jihong Qu

IPC: A61B5/14

CPC classification number: A61N1/3702 ,  A61B5/0006 ,  A61B5/02028 ,  A61B5/076 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4869 ,  A61B2562/02 ,  A61N1/05 ,  A61N1/36521 ,  A61N1/36557 ,  G01N13/04

Abstract: Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an osmometric sensor, the osmometric sensor configured to generate a signal corresponding to the osmotic strength of a bodily fluid, and a controller in communication with the osmometric sensor, the controller configured to receive and process the signal corresponding to the osmotic strength of a bodily fluid. Other aspects and embodiments are provided herein.

Abstract translation: 本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。 在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括渗透传感器，所述渗透传感器被配置为产生对应于体液的渗透强度的信号，以及与所述渗透传感器通信的控制器，所述控制器被配置为 接收和处理对应于体液渗透强度的信号。 本文提供了其它方面和实施例。

公开(公告)号：US20100071446A1

公开(公告)日：2010-03-25

申请号：US12563046

申请日：2009-09-18

Applicant: David Brown

Inventor： David Brown

IPC: G01N13/04 ,  G01N1/10

CPC classification number: G01N13/04 ,  G01N1/4055 ,  G01N2001/4061

Abstract: A solute concentration measurement device is disclosed. The device may comprise a filter membrane, an exchange chamber, a sensing chamber, a separator, and a sensor. The device may be configured to be placed in fluid communication with a sample solution containing a solute and a solvent. The filter membrane may provide selective fluid communication between the solution and the exchange chamber. The separator may separate the exchange chamber from the sensing chamber and cause a change in a condition of the sensing chamber corresponding to a change of a condition of the exchange chamber. The sensor may sense the condition pertaining to the sensing chamber and calculate the concentration of the sample solution corresponding to this change.

Abstract translation: 公开了一种溶质浓度测定装置。 该装置可以包括过滤膜，交换室，感测室，分离器和传感器。 该装置可以被配置为与含有溶质和溶剂的样品溶液流体连通。 过滤膜可以在溶液和交换室之间提供选择性的流体连通。 分离器可以将交换室与感测室分开，并且使得感应室的状态改变对应于交换室的状态的改变。 传感器可以感测与感测室相关的状态，并计算与该变化相对应的样品溶液的浓度。

公开(公告)号：US20080053206A1

公开(公告)日：2008-03-06

申请号：US11930270

申请日：2007-10-31

Applicant: Govindarajan Natarajan ,  James Humenik ,  Scott Partington ,  Srinivasa Reddy

Inventor： Govindarajan Natarajan ,  James Humenik ,  Scott Partington ,  Srinivasa Reddy

IPC: G01N13/04 ,  G01N27/00 ,  G01N27/26

CPC classification number: G01N13/04 ,  Y10T436/11

Abstract: An apparatus and a method are disclosed for providing point of care testing for osmolarity of a bodily fluid. An apparatus is disclosed as having a fluid pathway passing through it for receiving and testing a sample fluid. The invention permits osmolarity testing of a sample fluid wherein the sample fluid has a volume of less than approximately 30 nL, and implements a method and device to measure fluid osmolarity in a clinical setting quickly and accurately, while also reducing evaporation of the fluid.

Abstract translation: 公开了一种用于提供用于体液的渗透压的护理测试点的装置和方法。 公开了一种具有通过它的流体路径用于接收和测试样品流体的装置。 本发明允许样品流体的渗透压测试，其中样品流体具有小于约30nL的体积，并且实现了在临床设置中快速且准确地测量流体渗透压的方法和装置，同时还减少了流体的蒸发。

公开(公告)号：US07182509B2

公开(公告)日：2007-02-27

申请号：US11115115

申请日：2005-04-27

Applicant: Christopher J. Corbett

Inventor： Christopher J. Corbett

IPC: A61B5/01 ,  G01N33/48 ,  G01N13/04 ,  G01N25/04

CPC classification number: G01N25/06 ,  G01N13/04

Abstract: The invention is an apparatus for determining a temperature at which a phase change occurs in a fluid sample, a method for measuring a temperature at which a phase change occurs in a sample and a sample cell. An apparatus for determining a temperature at which a phase change occurs in a fluid sample 60′ in accordance with the invention includes a sample cell (12′)for providing direct collection of the sample from a sample source (74) which is collected and retained at a collecting end thereof by capillary attraction between the collecting end and the sample, the sample cell including a longitudinal passage (78) extending from the collecting end to a far end through which light is transmitted to provide an image of the sample as retained at the collecting end of the passage and with a cross sectional area of the passage being greater at the far end than at the collecting end; a heating and cooling assembly (14), including a temperature sensing device (44), the heating and cooling assembly holding and thermally contacting the sample cell during the determining of the temperature by the temperature measuring device at which the phase change occurs while the sample is positioned in the collecting end; and an illumination system (16) for directing a light beam to the collecting end, through the sample, through the longitudinal passage and out of the far end to permit viewing of the sample from the far end to determine the temperature at which the phase change occurs.

Abstract translation: 本发明是一种用于确定流体样品中发生相变的温度的装置，用于测量在样品和样品池中发生相变的温度的方法。 用于确定在根据本发明的流体样品60'中发生相变的温度的装置包括用于从采集和保留的样品源（74）直接收集样品的样品池（12'） 在收集端和样品之间的毛细管吸引的收集端处，样品池包括从收集端延伸到远端的纵向通道（78），通过该远端透射光以提供保留在样品中的样品的图像 通道的收集端和通道的横截面积在远端比在收集端处更大; 包括温度感测装置（44）的加热和冷却组件（14），所述加热和冷却组件在由相变发生的温度测量装置确定温度期间保持并热接触样品池，而样品 位于收集端; 以及照明系统（16），用于将光束通过样品通过所述纵向通道引导到所述收集端，并且远离所述远端以允许从所述远端观察所述样品，以确定所述相变的温度 发生。