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公开(公告)号：US07261889B2
公开(公告)日：2007-08-28
申请号：US11081640
申请日：2005-03-17
申请人： Eckard Weber , Howard I. Katz
发明人： Eckard Weber , Howard I. Katz
CPC分类号： A61K31/135 , A61K31/165 , A61K31/24 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505 , Y10S435/81 , Y10S514/816 , Y10S514/818
摘要： Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
摘要翻译： 公开了逆转局部麻醉的方法。 所述方法包括施用局部麻醉剂和α-肾上腺素能受体激动剂以诱导局部麻醉，然后用低剂量的α肾上腺素能受体拮抗剂逆转麻醉。 还公开了包含局部麻醉剂，α肾上腺素能受体激动剂和低剂量α肾上腺素能受体拮抗剂的试剂盒。
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公开(公告)号：US20020183396A1
公开(公告)日：2002-12-05
申请号：US10155020
申请日：2002-05-28
发明人： Eckard Weber , Howard I. Katz
IPC分类号： A61K031/137
CPC分类号： A61K31/135 , A61K31/165 , A61K31/24 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505 , Y10S435/81 , Y10S514/816 , Y10S514/818
摘要： Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
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公开(公告)号：US20090076023A1
公开(公告)日：2009-03-19
申请号：US12275556
申请日：2008-11-21
申请人： Eckard WEBER , Howard I. Katz
发明人： Eckard WEBER , Howard I. Katz
IPC分类号： A61K31/496 , A61K31/4164 , A61K31/164 , A61P25/00
CPC分类号： A61K31/135 , A61K31/165 , A61K31/24 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505 , Y10S435/81 , Y10S514/816 , Y10S514/818
摘要： Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
摘要翻译： 公开了逆转局部麻醉的方法。 所述方法包括施用局部麻醉剂和α肾上腺素能受体激动剂以诱导局部麻醉，然后用低剂量的α肾上腺素能受体拮抗剂逆转麻醉。 还公开了包含局部麻醉剂，α肾上腺素能受体激动剂和低剂量α肾上腺素能受体拮抗剂的试剂盒。
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公开(公告)号：US06872390B2
公开(公告)日：2005-03-29
申请号：US10155020
申请日：2002-05-28
申请人： Eckard Weber , Howard I. Katz
发明人： Eckard Weber , Howard I. Katz
IPC分类号： A61K45/06 , A61K20060101 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/24 , A61K31/415 , A61K31/417 , A61K31/44 , A61K31/445 , A61K31/505 , A61K38/46 , A61P23/02 , A61P43/00 , A01N25/00
CPC分类号： A61K31/135 , A61K31/165 , A61K31/24 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505 , Y10S435/81 , Y10S514/816 , Y10S514/818
摘要： Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
摘要翻译： 公开了逆转局部麻醉的方法。 所述方法包括施用局部麻醉剂和α肾上腺素能受体激动剂以诱导局部麻醉，然后用低剂量的α肾上腺素能受体拮抗剂逆转麻醉。 还公开了包含局部麻醉剂，α肾上腺素能受体激动剂和低剂量α肾上腺素能受体拮抗剂的试剂盒。
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公开(公告)号：US07575757B2
公开(公告)日：2009-08-18
申请号：US11082968
申请日：2005-03-18
申请人： Andrew X. Chen , Julius Knowles , Eckard Weber
发明人： Andrew X. Chen , Julius Knowles , Eckard Weber
IPC分类号： A61K9/08 , A61K31/417 , A61K31/497 , A61K47/12 , A61K47/16 , A61K47/26
CPC分类号： A61K31/4709 , A61K31/4745 , Y10S514/818 , A61K2300/00
摘要： The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
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6.发明授权Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof 有权α-肾上腺素能受体拮抗剂的稳定制剂及其用途公开(公告)号：US07569230B2
公开(公告)日：2009-08-04
申请号：US11611504
申请日：2006-12-15
申请人： Andrew X Chen , Julius Knowles , Eckard Weber
发明人： Andrew X Chen , Julius Knowles , Eckard Weber
IPC分类号： A61K9/08 , A61K31/417 , A61K31/497 , A61K47/12 , A61K47/16 , A61K47/26
CPC分类号： A61K31/4709 , A61K31/4745 , Y10S514/818 , A61K2300/00
摘要： The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
摘要翻译： 本发明提供包含α-肾上腺素能受体拮抗剂的组合物和稳定的液体制剂及其用于增加血流量的用途。 在一个实施方案中，本发明的稳定的液体制剂可用于逆转麻醉剂，优选与α肾上腺素能受体激动剂联合施用的持久的局部麻醉剂的作用。
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7.发明授权Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy 有权表征抗生素浸渍递送系统作为牙髓内药物治疗牙根治疗公开(公告)号：US07331787B2
公开(公告)日：2008-02-19
申请号：US10812638
申请日：2004-03-29
申请人： Mario Abdennour , Philip Stashenko , Michele Scrime , Jack Gilad , Max Goodson
发明人： Mario Abdennour , Philip Stashenko , Michele Scrime , Jack Gilad , Max Goodson
IPC分类号： A61C5/02
CPC分类号： A61K47/32 , A61C5/40 , A61K9/0063 , A61K9/0092
摘要： Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
摘要翻译： 描述了包含可渗透药物的生物相容性聚合物载体或药物组合的根管纤维。 这样的纤维可以用于例如药物局部递送和持续释放到牙周或肛门内治疗部位的方法。 所述的根管纤维包括改良的牙周纤维和颅内纤维。
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公开(公告)号：US20010056125A1
公开(公告)日：2001-12-27
申请号：US09852751
申请日：2001-05-11
发明人： Eckard Weber , Howard I. Katz
IPC分类号： A61K031/137
CPC分类号： A61K31/135 , A61K31/165 , A61K31/24 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505 , Y10S435/81 , Y10S514/816 , Y10S514/818
摘要： Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
摘要翻译： 公开了逆转局部麻醉的方法。 所述方法包括施用局部麻醉剂和α肾上腺素能受体激动剂以诱导局部麻醉，然后用低剂量的α肾上腺素能受体拮抗剂逆转麻醉。 还公开了包含局部麻醉剂，α肾上腺素能受体激动剂和低剂量α肾上腺素能受体拮抗剂的试剂盒。
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9.发明授权Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof 有权α-肾上腺素能受体拮抗剂的稳定制剂及其用途公开(公告)号：US07229630B2
公开(公告)日：2007-06-12
申请号：US10465810
申请日：2003-06-20
申请人： Andrew X. Chen , Julius Knowles , Eckard Weber
发明人： Andrew X. Chen , Julius Knowles , Eckard Weber
CPC分类号： A61K31/4709 , A61K31/4745 , Y10S514/818 , A61K2300/00
摘要： The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
摘要翻译： 本发明提供包含α-肾上腺素能受体拮抗剂的组合物和稳定的液体制剂及其用于增加血流量的用途。 在一个实施方案中，本发明的稳定的液体制剂可用于逆转麻醉剂，优选与α肾上腺素能受体激动剂联合施用的持久的局部麻醉剂的作用。
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10.发明申请Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof 有权α-肾上腺素能受体拮抗剂的稳定制剂及其用途公开(公告)号：US20050203099A1
公开(公告)日：2005-09-15
申请号：US11082968
申请日：2005-03-18
申请人： Andrew Chen , Julius Knowles , Eckard Weber
发明人： Andrew Chen , Julius Knowles , Eckard Weber
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/517
CPC分类号： A61K31/4709 , A61K31/4745 , Y10S514/818 , A61K2300/00
摘要： The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
摘要翻译： 本发明提供包含α-肾上腺素能受体拮抗剂的组合物和稳定的液体制剂及其用于增加血流量的用途。 在一个实施方案中，本发明的稳定的液体制剂可用于逆转麻醉剂，优选与α肾上腺素能受体激动剂联合施用的持久的局部麻醉剂的作用。
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