公开(公告)号：US20210015822A1

公开(公告)日：2021-01-21

申请号：US16929893

申请日：2020-07-15

Applicant: OncoArendi Therapeutics S.A.

Inventor： Marzena Mazur ,  Gleb Andryianau ,  Lukasz Joachimiak ,  Wojciech Czestkowski ,  Michal L. Kowalski ,  Piotr Niedziejko ,  Sylwia Olejniczak ,  Krzysztof Matyszewski ,  Robert Koralewski ,  Jacek P. Olczak ,  Adam A. Golebiowski ,  Agnieszka Bartoszewicz

IPC: A61K31/5365 ,  A61K45/06 ,  A61K31/5355 ,  C07D413/14 ,  A61K31/454 ,  C07D401/14 ,  A61K31/4545 ,  C07D498/04

Abstract: Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

公开(公告)号：US10912755B2

公开(公告)日：2021-02-09

申请号：US16540747

申请日：2019-08-14

Applicant: OncoArendi Therapeutics S.A.

Inventor： Roman Blaszczyk ,  Joanna Brzezinska ,  Anna Gzik ,  Adam A. Golebiowski ,  Julita Nowicka ,  Bartlomiej Borek ,  Marek Dziegielewski ,  Karol Jedrzejczak ,  Krzysztof Matyszewski ,  Jacek Olczak

IPC: A61K31/69 ,  A61K31/343 ,  A61P11/00 ,  A61K31/23 ,  A61K31/235 ,  A61K31/133 ,  A61K31/335 ,  C07F5/02 ,  C07F5/04

Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.

公开(公告)号：US10538508B2

公开(公告)日：2020-01-21

申请号：US16277321

申请日：2019-02-15

Applicant: OncoArendi Therapeutics S.A.

Inventor： Marzena Mazur ,  Robert Koralewski ,  Bartlomiej Borek ,  Sylwia Olejniczak ,  Wojciech J. Czestkowski ,  Michal C. Piotrowicz ,  Jacek P. Olczak ,  Adam A. Golebiowski ,  Agnieszka Bartoszewicz ,  Elzbieta Maziarz ,  Michal L. Kowalski

IPC: A61K31/5377 ,  C07D401/14 ,  C07D487/04 ,  C07D413/14 ,  C07D498/04 ,  C07D417/14

Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

公开(公告)号：US12053451B2

公开(公告)日：2024-08-06

申请号：US17168291

申请日：2021-02-05

Applicant: OncoArendi Therapeutics S.A.

Inventor： Roman Blaszczyk ,  Joanna Brzezińska ,  Anna Gzik ,  Adam Golebiowski ,  Julita Nowicka ,  Bartlomiej Borek ,  Marek Dziegielewski ,  Karol Jedrzejczak ,  Krzysztof Matyszewski ,  Jacek Olczak

IPC: C07F5/02 ,  A61K31/133 ,  A61K31/23 ,  A61K31/235 ,  A61K31/33 ,  A61K31/335 ,  A61K31/343 ,  A61K31/69 ,  A61P11/00 ,  C07F5/04

CPC classification number: A61K31/343 ,  A61K31/133 ,  A61K31/23 ,  A61K31/235 ,  A61K31/33 ,  A61K31/335 ,  A61K31/69 ,  A61P11/00 ,  C07F5/025 ,  C07F5/04

Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.

公开(公告)号：US20210260019A1

公开(公告)日：2021-08-26

申请号：US17168291

申请日：2021-02-05

Applicant: OncoArendi Therapeutics S.A.

Inventor： Roman Blaszczyk ,  Joanna Brzezinska ,  Anna Gzik ,  Adam Golebiowski ,  Julita Nowicka ,  Bartlomiej Borek ,  Marek Dziegielewski ,  Karol Jedrzejczak ,  Krzysztof Matyszewski ,  Jacek Olczak

IPC: A61K31/343 ,  A61P11/00 ,  A61K31/133 ,  A61K31/23 ,  A61K31/235 ,  A61K31/33 ,  A61K31/335 ,  A61K31/69 ,  C07F5/02 ,  C07F5/04

Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.

公开(公告)号：US10851099B2

公开(公告)日：2020-12-01

申请号：US16369982

申请日：2019-03-29

Applicant: OncoArendi Therapeutics S.A.

Inventor： Roman Blaszczyk ,  Anna Gzik ,  Bartlomiej Borek ,  Marek Dziegielewski ,  Karol Jedrzejczak ,  Julita Nowicka ,  Jacek Chrzanowski ,  Joanna Brzezinska ,  Adam Golebiowski ,  Jacek Olczak ,  Marcin Mikolaj Grzybowski ,  Jolanta Peczkowicz-Szyszka

IPC: C07F5/02 ,  A61K31/454 ,  C07D471/04 ,  A61P11/16 ,  A61P9/00 ,  A61P17/02 ,  A61P37/00 ,  A61P35/00 ,  C07K5/02 ,  C07D211/60 ,  A61K45/06

Abstract: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.

公开(公告)号：US10208020B2

公开(公告)日：2019-02-19

申请号：US15908249

申请日：2018-02-28

Applicant: OncoArendi Therapeutics S.A.

Inventor： Marzena Mazur ,  Robert Koralewski ,  Bartlomiej Borek ,  Sylwia Olejniczak ,  Wojciech J. Czestkowski ,  Michal C. Piotrowicz ,  Jacek P. Olczak ,  Adam A. Golebiowski ,  Agnieszka Bartoszewicz ,  Elżbieta Maziarz ,  Michal Łukasz Kowalski

IPC: C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

公开(公告)号：US09944624B2

公开(公告)日：2018-04-17

申请号：US15255226

申请日：2016-09-02

Applicant: OncoArendi Therapeutics S.A.

Inventor： Marzena Mazur ,  Robert Koralewski ,  Bartlomiej Borek ,  Sylwia Olejniczak ,  Wojciech J. Czestkowski ,  Michał C. Piotrowicz ,  Jacek P. Olczak ,  Adam A. Golebiowski ,  Agnieszka Bartoszewicz ,  Elżbieta Maziarz ,  Michał Łukasz Kowalski

IPC: C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

CPC classification number: C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

公开(公告)号：US20210147401A1

公开(公告)日：2021-05-20

申请号：US17032232

申请日：2020-09-25

Applicant: OncoArendi Therapeutics S.A.

Inventor： Grzegorz Witkowski ,  Marta Magdycz ,  Magdalena Tyszkiewicz ,  Marcin Zakrzewski ,  Stanislaw Pikul

IPC: C07D413/14 ,  C07D413/04 ,  C07D211/74

Abstract: The present invention relates to a process for the synthesis of 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine in two hydrated crystalline forms and in one anhydrous crystalline form. The present invention further relates to methyl (Z)-4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)-N-cyanopiperidine-1-carbimidothioate which is an intermediate in this process.

公开(公告)号：US10391077B2

公开(公告)日：2019-08-27

申请号：US15584193

申请日：2017-05-02

Applicant: OncoArendi Therapeutics S.A.

Inventor： Roman Blaszczyk ,  Joanna Brzezińska ,  Anna Gzik ,  Adam Golebiowski ,  Julita Nowicka ,  Bartlomiej Borek ,  Marek Dziegielewski ,  Karol Jedrzejczak ,  Krzysztof Matyszewski ,  Jacek Olczak

IPC: C07F5/02 ,  A61K31/69 ,  A61K31/343 ,  A61K31/23 ,  A61K31/235 ,  A61K31/33 ,  A61K31/335 ,  C07F5/04

Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.