-
1.发明公开公开(公告)号：US20240360232A1
公开(公告)日：2024-10-31
申请号：US18612039
申请日：2024-03-21
Applicant: SANOFI BIOTECHNOLOGY , REGENERON PHARMACEUTICALS, INC.
Inventor： Raolat Abdulai , Elizabeth Laws , Leda Mannent , Lacey Robinson , Marcella Ruddy
CPC classification number: C07K16/2866 , A61K45/06 , A61P11/00 , A61K2039/505 , A61K2039/545
Abstract: Methods for treating or preventing chronic obstructive pulmonary disease (COPD) in a subject are provided. Methods comprising administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof, are provided.
-
公开(公告)号：US12128029B2
公开(公告)日：2024-10-29
申请号：US18391451
申请日：2023-12-20
Applicant: VICORE PHARMA AB
Inventor： Carl-Johan Dalsgaard , Rohit Batta
IPC: A61K31/4178 , A61K9/48 , A61P1/00 , A61P11/00
CPC classification number: A61K31/4178 , A61K9/485 , A61K9/4858 , A61P1/00 , A61P11/00
Abstract: According to the invention there is provided a method of improving (e.g. restoring) function in a patient having idiopathic pulmonary fibrosis, which method comprises perorally administering a therapeutically-effective amount of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically acceptable salt thereof, to said patient. Said treatment is capable of treating said IPF in a therapeutic, including a curative, fashion.
-
公开(公告)号：US20240352461A1
公开(公告)日：2024-10-24
申请号：US18765286
申请日：2024-07-07
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , SpliSense Ltd.
Inventor： Bat Sheva KEREM , Efrat OZERI-GALAI , Yifat OREN , Ofra BARCHAD-AVITZUR
IPC: C12N15/113 , A61K31/7088 , A61K45/06 , A61P11/00
CPC classification number: C12N15/113 , A61K31/7088 , A61K45/06 , A61P11/00 , C12N2310/11 , C12N2320/31
Abstract: The present invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, including compositions comprising the oligonucleotides, and uses thereof, such as for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849+10 Kb C-to-T, optionally in combination with additional CF therapeutics.
-
4.发明公开公开(公告)号：US20240350575A1
公开(公告)日：2024-10-24
申请号：US18640008
申请日：2024-04-19
Inventor： Jinsong LIAO
CPC classification number: A61K36/73 , A61K36/28 , A61K36/31 , A61P11/00 , A61K2236/15 , A61K2236/333 , A61K2236/53
Abstract: A plant extract for alleviating pulmonary fibrosis, and a preparation method and a use thereof are provided. The preparation method includes the following steps: (1) crushing Aronia melanocarpa (Michx.) Elliott berries after drying, mixing the crushed berries with ethanol for soaking and extraction, and filtering the mixture to obtain an extract solution of Aronia melanocarpa (Michx.) Elliott; (2) crushing Cynara scolymus L. buds after drying, mixing the crushed buds with ethanol for extraction, and filtering the mixture to obtain an extract solution of Cynara scolymus L.; (3) crushing Brassica oleracea var. albiflora Kuntze roots after drying, and mixing the crushed roots with ethanol for ultrasonic extraction to obtain an extract solution of Brassica oleracea var. albiflora Kuntze; (4) mixing the extract solutions of Aronia melanocarpa (Michx.) Elliott, Cynara scolymus L. and Brassica oleracea var. albiflora Kuntze to obtain the plant extract for alleviating pulmonary fibrosis.
-
公开(公告)号：US20240350406A1
公开(公告)日：2024-10-24
申请号：US18539744
申请日：2023-12-14
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： David H. Ingbar , Timothy P. Rich , Robert J. Schumacher , Jianxun Lei , Maneesh Bhargava
IPC: A61K9/00 , A61K31/198 , A61P11/00
CPC classification number: A61K9/0078 , A61K31/198 , A61P11/00
Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
-
Patent Agency Ranking
公开(公告)号：US20240343828A1
公开(公告)日：2024-10-17
申请号：US18595079
申请日：2024-03-04
Applicant: Northwestern University
Inventor： Ankit Bharat , Yuanqing Yan , GR Scott Budinger , Ali Shilatifard
IPC: C07K16/38 , A61K31/4706 , A61K31/506 , A61K31/517 , A61K31/5377 , A61P11/00 , C07K16/28 , C12N15/113
CPC classification number: C07K16/38 , A61K31/4706 , A61K31/506 , A61K31/517 , A61K31/5377 , A61P11/00 , C07K16/2863 , C12N15/113 , C12N2310/14 , C12N2310/141
Abstract: Provided herein is a method of treating or preventing acute or chronic lung disease in a subject, comprising administering an agent that modulates the expression of Serine Protease Inhibitor Kazal-type 1 (SPINK1) to the subject.
-
公开(公告)号：US20240342210A1
公开(公告)日：2024-10-17
申请号：US18701054
申请日：2022-10-14
Applicant: The General Hospital Corporation
Inventor： Lilit Garibyan , William A. Farinelli , Richard Rox Anderson
CPC classification number: A61K33/00 , A61K9/0019 , A61K47/10 , A61P11/00
Abstract: Disclosed herein are methods that allow for treating sleep apnea by removing adipose tissue and increasing collagen production in a patient's upper airways by injecting ice slurry comprising ingredients such as sterile water, a biocompatible surfactant such as glycerol, and saline into the target area.
-
公开(公告)号：US20240336653A1
公开(公告)日：2024-10-10
申请号：US18007626
申请日：2021-05-19
Applicant: Shenzhen Turier Biotech Co., Ltd.
Inventor： Xianxing JIANG , Rui WANG , Nazi SONG
Abstract: The present invention relates to peptide compound targeting elastin-derived peptides and use thereof. The peptide comprises a parent peptide represented by the following amino acid sequence: R1-Val-Xa2-Gly-Ser-Pro-Ser-Ala-Gln-Xa9-Xa10-Ala-Ser-Pro-Xa14, and is characterized by better biological activity, higher safety and stability, high synthesis yield, low cost, etc. The peptide compound may be used for treating hepatic fibrosis and fibrotic conditions accompanying hepatic disease as well as idiopathic pulmonary fibrosis and fibrotic conditions accompanying pulmonary disease.
-
公开(公告)号：US20240335468A1
公开(公告)日：2024-10-10
申请号：US18578811
申请日：2022-07-08
Applicant: HYPO-STREAM LIMITED
Inventor： Myles Dakin , Richard Aspinall , Thomas Kenny
IPC: A61K33/20 , A61K9/00 , A61K9/08 , A61K47/02 , A61P1/18 , A61P11/00 , A61P19/02 , A61P31/14 , A61P37/02
CPC classification number: A61K33/20 , A61K9/0078 , A61K9/008 , A61K9/08 , A61K47/02 , A61P1/18 , A61P11/00 , A61P19/02 , A61P31/14 , A61P37/02
Abstract: The present invention relates to a hypochlorite solution for use in the prevention or treatment of a respiratory condition or disease in a patient; preferably a mammal, more preferably a human. The present invention also relates to a hypochlorite solution for use in the prevention or treatment of an inflammatory or auto-immune response, condition or disease in a patient, preferably a mammal, more preferably a human, wherein administration of the hypochlorite solution is by inhalation of the hypochlorite solution. The hypochlorite solution comprises hypochlorite in a concentration range of about 0.005-0.2 wt % (about 50-2000 ppm by wt).
-
公开(公告)号：US20240317767A1
公开(公告)日：2024-09-26
申请号：US18670264
申请日：2024-05-21
Applicant: AstraZeneca AB
Inventor： Johan Olof BRODDEFALK , Hans Fredrik EMTENÂS , Kenneth Lars GRANBERG , Malin Anita LEMURELL , Daniel Tor PETTERSEN , Alleyn Thomas PLOWRIGHT , Lars Johan Andreas ULANDER
IPC: C07D487/04 , A61K31/4155 , A61K31/4985 , A61P9/00 , A61P9/10 , A61P11/00 , C07D231/40 , C07D231/44 , C07D231/50 , C07D413/12 , C07D417/12 , C07D498/04
CPC classification number: C07D487/04 , A61K31/4155 , A61K31/4985 , A61P9/00 , A61P9/10 , A61P11/00 , C07D231/40 , C07D231/44 , C07D231/50 , C07D413/12 , C07D417/12 , C07D498/04
Abstract: The present application relates to novel compounds of formula (I)
to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
-
-
-
-
-
-
-
-
-
Search Results
1004
records
(took 0.03 seconds)
