公开(公告)号：US20220177546A1

公开(公告)日：2022-06-09

申请号：US17598029

申请日：2020-03-27

申请人： PHOENIX TISSUE REPAIR, INC.

发明人： Mark Desouza ,  Malini Viswanathan ,  Pierra-Alain Girod ,  Alexandre Regamey ,  Valerie Le Fourn ,  David Calabrese ,  John Gill ,  Megan Gottlieb ,  Amie Lundquist ,  Anna Tchoudakova ,  George Enriquez ,  Rahul Chelikani ,  Thomas Gagliardi ,  Tatiana Laivins ,  Hang Yuan

IPC分类号： C07K14/78 ,  C12N9/02

摘要： The present disclosure provides production systems and host cells to produce collagen 7 compositions comprising recombinant collagen 7 and/or functional variants thereof. The host cells are genetically engineered to stably express rCol7 and functional variants thereof. The collagen 7 composition can be used to restore collagen 7 levels in a subject in need, and for preventing, preventing the progression of, alleviating, and delaying the on-set of a skin condition, e.g., skin wound associated with dystrophic epidermolysis bullosa (DEB).

公开(公告)号：US10921332B2

公开(公告)日：2021-02-16

申请号：US15646303

申请日：2017-07-11

申请人： PHOENIX TISSUE REPAIR, INC.

发明人： Sheila G. Magil

IPC分类号： G01N33/94 ,  G01N33/68

摘要： The present disclosure features a method of detecting and/or quantifying collagen VII or a fragment thereof in a sample, the method including contacting the sample with collagen IV or a fragment thereof which binds to collagen VII; and contacting the sample with an anti-collagen VII antibody, wherein the anti-collagen VII antibody binds to the NC2 domain of collagen VII; detecting binding of the anti-collagen VII antibody to thereby detect and/or quantify an amount of collagen VII or the fragment thereof in the sample. A method of evaluating or processing a collagen VII preparation is also provided.

公开(公告)号：US10695395B2

公开(公告)日：2020-06-30

申请号：US16065512

申请日：2016-12-21

申请人： SHIRE HUMAN GENETIC THERAPIES, INC.

发明人： Igor Quinones-Garcia ,  Lin Guey ,  Kris Lowe ,  Vinh Nguyen ,  Bing He ,  Amey Bandekar ,  Sujit Basu

IPC分类号： A61K38/01 ,  A61Q19/08 ,  A61K8/65 ,  A61K8/60 ,  A61K38/39 ,  C07K14/78 ,  A61K8/44 ,  A61K8/20 ,  A61K8/49 ,  A61K8/24 ,  A61K9/00 ,  A61P17/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26

摘要： The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.

公开(公告)号：US10669327B2

公开(公告)日：2020-06-02

申请号：US16084998

申请日：2017-03-10

申请人： PHOENIX TISSUE REPAIR, INC.

发明人： Igor Quinones-Garcia ,  Benjamin Simeone ,  Raymond Lillie ,  Ting Yang ,  David Nichols

IPC分类号： C07K14/78 ,  A61K38/39 ,  C07K1/16 ,  C07K1/34

摘要： The present disclosure provides methods for capturing recombinant collagen 7 from cell culture and methods of purifying recombinant collagen 7. Also provided are compositions comprising purified recombinant collagen 7 that may be used for administration to humans.

公开(公告)号：US20230414698A1

公开(公告)日：2023-12-28

申请号：US18169368

申请日：2023-02-15

申请人： Phoenix Tissue Repair, Inc.

发明人： Igor QUINONES-GARCIA ,  Lin Guey ,  Kris Lowe ,  Vinh Nguyen ,  Bing He ,  Amey Bandekar ,  Sujit Basu

IPC分类号： A61K38/01 ,  A61Q19/08 ,  A61K8/65 ,  A61K8/60 ,  A61K38/39 ,  C07K14/78 ,  A61K8/44 ,  A61K8/20 ,  A61K8/49 ,  A61K8/24 ,  A61K9/00 ,  A61P17/02

CPC分类号： A61K38/014 ,  A61Q19/08 ,  A61K8/65 ,  A61K8/60 ,  A61K38/39 ,  C07K14/78 ,  A61K8/44 ,  A61K8/20 ,  A61K8/4993 ,  A61K8/24 ,  A61K9/0019 ,  A61P17/02 ,  A61K47/10

摘要： The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.

公开(公告)号：US20210132091A1

公开(公告)日：2021-05-06

申请号：US17141586

申请日：2021-01-05

申请人： PHOENIX TISSUE REPAIR, INC.

发明人： Sheila G. Magil

IPC分类号： G01N33/94 ,  G01N33/68

摘要： The invention features a method of detecting and/or quantifying collagen VII or a fragment thereof in a sample, by contacting the sample with collagen IV which binds to collagen VII; and detecting binding of collagen IV with collagen VII.